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For additional information, please contact Dr. Anne Cappola, MD, ScM
Phone: (215) 573-5359

Email

 

Cappola, Anne R., MD, ScM  Program Director.
Associate Professor, Division of Endocrinology, Diabetes and Metabolism

Expertise: Metabolic alterations that occur with aging and the clinical impact of these changes; patient-oriented research

Current Fellows:

  • Paige Meizlik – Mentor: Anne Cappola
  • Cassie Tran – Mentor: Joe Baur
  • Romeo Papazyan  – Mentor: Mitch Lazar
  • Qinglan (Helen) Liu – Mentor: Tracy Bale

Obesity and diabetes mellitus are reaching epidemic proportions worldwide.  In the United States alone, the estimated cost of diabetes in 2007 was $174 billion, including $116 billion in excess medical expenditures and $58 billion in reduced national productivity. The Training Program in Diabetes, Endocrinology and Metabolic Diseases provides superb preparation for those scientists committed to careers in research into diabetes, endocrinology and metabolism. 

The program is designed to accommodate both Ph.D. scientists as well as physician scientists with M.D. or M.D, Ph.D. degrees, pursuing careers in either basic or patient-oriented research.  Our 19 training faculty have primary appointments in seven Medical School Departments and consist of 12 professors, 5 associate professors, and assistant 2 professors.

Training grant faculty bring to the program expertise in b-cell development and function, hormone action, physiology, diabetic complications, genetics in humans and model organisms, transcriptional regulation, patient oriented research, epidemiology and biostatistics. Ultimately, the goal of this program is to help train the next generation of physician and basic researchers in research into the prevention and treatment of diabetes and other endocrine disorders.

Mentors:

Rexford Ahima, M.D., Ph.D.
Professor, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism

Expertise:
Energy homeostasis, neuroendocrinology of obesity, and CNS regulation of glucose and lipids
Baur, Joseph A., Ph.D.
Assitant Professor, Department of Physiology; (Division of Endocrinology, Diabetes and Metabolism)

Expertise:
Molecular mechanisms of caloric restriction and aging
Kendra Bence, Ph.D.
School of Veterinary Medicine; Department of Biomedical Sciences

Expertise:
Mouse models of obesity/diabetes, neuronal control of energy balance, signal transduction, role of protein tyrosine phosphatases in obesity and cancer
Bogner, Hillary R., M.D., M.S.C.E.
Associate Professor, Department of Family Medicine and Community Health

Expertise:
Depression in older adults with diabetes

Harold I Feldman, M.D., M.S.C.E.
Professor and Department Chair:
Department of Family Medicine and Community Health

Expertise:
Epidemiology, patient-oriented research, kidney disease

Klaus H. Kaestner, Ph.D.
Professor, Department of Genetics

Expertise:
Transcription factor regulation of organogenesis and physiology of the liver, pancreas and gastrointestinal tract
Mitchell A. Lazar, M.D., Ph.D.
Professor and Division Chief
Department of Genetics and Medicine, Division of Endocrinology, Diabetes and Metabolism

Expertise:
Signal transduction by nuclear receptors and obesity and insulin resistance
Michael Levinie, M.D.
Professor and Division Chief, Department of Pediatrics; Division of Endocrinology and Diabetes

Expertise:
G protein coupled signal transduction; Molecular genetic analysis of disorders of bone and mineral metabolism; Inherited disorders of vitamin D metabolism

Long, Judith, M.D.
Associate Professor, Department of Medicine; Division of General Internal Medicine

Expertise: Social determinants of health and health care as they pertain to socioeconomic and racial disparities in diabetes

David  R. Manning, Ph.D.
Professor, Department of Systems Pharmacology and Translational Therapeutics

Expertise:
The process by which the binding of hormones to cell-surface receptors is translated into the regulation of target enzymes and ion channels.

Judy L. Meinkoth, Ph.D.
Professor, Department of Systems Pharmacology and Translational Therapeutics

Expertise:
Molecular basis of thyroid tumor initiation and progression, signal transduction, cell proliferation, differentiation, and apoptosis
Ali Naji, M.D., Ph.D.,
Professor, Department of Surgery

Expertise:
Modulation of auto-immunity and islet transplantation

Rader, Daniel J., M.D.
Professor, Div. Chief, and Dept. chair.
Department of Medicine;
Division of Translational Medicine and Human Genetics
(Department of Genetics)

Expertise: Novel pathways regulating lipid and lipoprotein metabolism and atherosclerosis inspired by unbiased studies of human genetics; factors regulating the structure and function of high density lipoproteins and the process of reverse cholesterol transport and their relationship to atherosclerosis

Michael R. Rickels, M.D., M.S.
Associate Professor, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism

Expertise: Patient-oriented research that aims at understanding the pathogenesis of different types of diabetes and the in vivo mechanisms of new diabetes treatments

Seale, Patrick, Ph.D.
Assistant Professor, Department of Cell and Developmental Biology

Expertise: Transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity

Rebecca A. Simmons, M.D.
Professor, Department of Pediatrics, Division of Neonatology

Expertise: Model of intrauterine growth retardation in the rat that leads to obesity and diabetes in later life

Charles A. Stanley, M.D.
Professor, Department of Pediatrics, Division of Endocrinology

Expertise: Genetic disorders of carbohydrate and fatty acid metabolism, insulin secretion

Doris A. Stoffers, M.D., Ph.D.
Professor, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism

Expertise: Transcription factors and signal transduction, embryonic development and adult regeneration of the endocrine pancreas, relationship of defects in these pathways to the pathophysiology of diabetes mellitus