M. Ishii, M. C. Fischer, K. Emami, A. Alavi, Z. Z. Spector, J. Yu, J. E. Baumgardner, M. Itkin, S. J. Kadlecek, J. Zhu, M. Bono, W. B. Gefter, D. A. Lipson, J. B. Shrager, R. R. Rizi,

The primary function of the respiratory system is to supply enough oxygen to the body to meet its metabolic needs and to remove carbon dioxide formed as a by-product of metabolism. To accomplish this, sufficient quantities of blood and air must be brought in close proximity to allow for the adequate exchange of gases. Conditions that perturb the effective exchange of gases are seen in virtually all respiratory disease processes; measures of lung function play an important role in the diagnosis, management, and treatment of pulmonary disorders. Recent advances in hyperpolarized (HP) contrast agents have led to new MR imaging–based pulmonary function tests. These tests may lead to a new paradigm in the management, treatment, and study of lung disease.

Radiologic Clinics of North America. 43(1):235-246 • January 2005