ALS Dementia (ALS)
Amyotrophic Lateral Sclerosis, commonly referred to as ALS or Lou Gehrig's Disease is a Motor Neuron Disease (MND). As MNDs progress, patients' motor neurons degenerate, and lose their ability to control muscles. Recently, the focus of some ALS research has shifted to understand the cognitive difficulties of patients with MND. In about 10% of patients, MND is accompanied by FTD. The fact that ubiquitinated TDP-43 is the common biochemical link for both FTD and MND helps to explain this connection. Greater recognition of the cognitive difficulties of people with MND will increase our understanding of the condition.