Susan M. Domchek, M.D. Medline search
Associate Professor of Medicine

The Rena Rowan Breast Center
University of Pennsylvania
14 Penn Tower
3400 Spruce Street
Philadelphia, PA 19104

(215) 615-3360 telephone

Board Certifications: Internal Medicine 1998

Medical School: Harvard Medical School

Residency: Internal Medicine, Massachusetts General Hospital

Fellowship: Hematology-Oncology, Dana-Farber Cancer Institute

Clinical Interests:
Breast Cancer, with expertise in the evaluation of breast cancer risk and breast cancer prevention.

Research Interests:
To refine breast cancer risk assessment and better understand genetic susceptibility to breast cancer. Additional research interests include the use of therapeutic cancer vaccines in the treatment of brest cancer.

Publications:

Domchek SM. Chemoprevention in BRCA1 and BRCA2 mutation carriers. Seminars in Breast Disease, 2003; in press.

Bendell JC, Domchek SM, Burstein HJ, Harris LN, Younger J, Kuter I, Bunnell C, Rue M, Gelman R, Winer EP. Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast cancer. Cancer. 2003; in press.

Domchek SM, Eisen A, Calzone K, Stopfer J, Blackwood A, Weber BL. Application of breast cancer risk prediction models in clinical practice. Journal of Clinical Oncology. 2003; 21:593-601.

Domchek SM and Weber BL. Advances in breast cancer biology. Current Opinions in Oncology. 2002; 14: 589-593.

Domchek SM. Invited Commentary: The utility of ductal lavage in breast cancer detection and risk assessment. Breast Cancer Research. 2002;4:51-53

Domchek SM, Hecht JL, Fleming MD, Pinkus GS, Canellos GP. Lymphomas of the breast: primary and secondary involvement. Cancer. 2002; 94:6-13.

Domchek SM, Younger J, Finkelstein DM, Seiden MV. Predictors of skeletal complications in metastatic breast cancer. Cancer. 2000; 89:363-8.

Piccione E, Case RD, Domchek SM, Hu P, Chaudhuri M, Backer JM, Schlessinger J, Shoelson SE. Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding. Biochemistry. 1993; 32:3197-202.

Domchek SM, Auger KR, Chatterjee S, Burke TR Jr, Shoelson SE. Inhibition of SH2 domain/phosphoprotein association by a nonhydrolyzable phosphonopeptide. Biochemistry. 1992; 31:9865-70.