Alan M. Gewirtz, MD Medline search
Professor of Medicine and Pathology
Leader, Stem Cell Biology & Therapeutics Program

713 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104

215-898-4499
215-573-2078 fax

Research Program
The focus of my laboratory has been the cell biology of normal and malignant human hematopoiesis. The laboratory has had a long standing interest in the extracellular regulation of human hematopoietic progenitor cell growth, in particular cells of the megakaryocyte lineage. We have also played a prominent role in the development of "antisense" gene squelching methods which allow the role of specific genes in regulating blood cell development to be investigated. Most recently, we have received funding from the National Space Biomedical Research Institute to study the effects of the deep space radiation environment on hematopoietic cell development. It is our ultimate goal to use the knowledge gained in various these studies to advance the development of more effective, and less toxic therapies for human leukemia.