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Laurence U. Buxbaum, M.D., Ph.D.

Laurence U. Buxbaum, M.D., Ph.D. Dr. Buxbaum is interested in the immunology of parasites and studies the initiation and maintenance of cell-mediated immunity (Th1 response) elicited by the protozoan parasite, Leishmania, using a murine model of cutaneous disease. He is examining the role of IL-10 in the suppression of a protective immune response to Leishmania mexicana, which usually causes chronic disease. He has also focused on the detrimental role of antibodies and their receptors in leishmaniasis. Recent work has begun on the role of glycolipids as targets of antibody responses.

Selected publications:

Buxbaum, L.U., Uzonna, J.E., Goldschmidt, M.H., and Scott, P. Control of New World cutaneous leishmaniasis is interleukin-12 independent but STAT4 dependent. Euro. J. Immunol. 32:3206-3215. 2002.

Buxbaum, L.U., Denise, H., Coombs, G.H., Alexander, J., Mottram, J.C., and Scott, P. Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity. J. Immunol. 171:3711-3717, 2003.

Buxbaum, L.U. and Scott, P. Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions. Infect. Immun. 73:2101-8, 2005.

Thomas, B.N., and Buxbaum, L.U. FcyRIII mediates immunoglobulin G-induced interleukin-10 and is required for chronic Leishmania mexicana lesions. Infect. Immun., 76:623-631, 2008.

Buxbaum, L.U. Type I IFNs promote the early IFN-y response and the IL-10 response in Leishmania mexicana infection. Parasite Immunol., 32: 153-160, 2010.

Chu, N., Thomas, B.N., Patel, S.R. and Buxbaum, L.U. IgG1 is pathogenic in Leishmania mexicana infection. J. Immunol., 185: 6939-6946, 2010.

Contact:
Laurence Buxbaum. M.D., Ph.D.
Research (151) Rm A505
VA Medical Center
3900 Woodland Ave.
Philadelphia, PA 19104
buxbaum@mail.med.upenn.edu
(215) 823-5800 x3426


Education:

Medical School: John Hopkins School of Medicine
Graduate School: John Hopkins School of Medicine
Medicine and ID Training: University of Pennsylvania
Academic Rank: Asst. Professor of Medicine