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Ian Frank,
M.D.
Dr. Frank’s
main area of research is the use of antiretroviral therapy to treat
HIV infection. He has been studying novel approaches to control HIV
replication, including the use of antiretroviral treatment interruption
and vaccines to augment the HIV specific immune responses as adjuctive
HIV therapy. He is also studying the etiologies of the complications
of long-term antiretroviral treatment, including hyperlipidemia and
insulin resistance.
Selected publications:
Frank I: Once-daily
HAART: toward a new treatment paradigm. Journal of Acquired Immunodeficiency
Syndromes. 31S10-15, 2002.
Otero M, Nunnari
G, Leto D, Sullivan J, Wang F-X, Frank I, Xu Y, Patel C, Dornadula G,
Kulkosky J, Pomerantz RJ. Peripheral blood dendritic cells are not a
major reservoir for HIV type 1 infected individuals on virally suppressive
HAART. AIDS Research and Human Retroviruses, 19:1097-1103, 2003.
Tershakovec AM,
Frank I, Rader D. HIV-related lipodystrophy and related factors. Atherosclerosis,
174:1-10, 2004.
Vogler M, Teppler
H, Gelman R, Weng Cherng D, Valentine F, Pomerantz R, Pollard R, Gonzalez
C J, Frank I, Lederman M M, Squires K, Mildvan D, Mahon L, Schock B,
Bell D, and the AIDS Clinical Trials Group 248 Study Team. Low-dose
daily subcutaneous interleukin-2 (IL-2) added to single or dual nucleoside
yherapy in HIV infection does not protect against CD4+T cell decline
or improve other indices of immune function: results of a randomized
controlled clinical trial (ACTG 248). Journal of Acquired Immunodeficiency
Syndromes. In press.
Frank I, Bosch RJ,
Fiscus S, Valentine F, Flexner C, Segal Y, Ruan P, Gulick R, Wood K,
Estep S, Fox L, Nevin T, Stevens M, and Eron, JJ Jr, for the ACTG 307
Protocol Team. Activity, Safety, and Immunologic Effects of Hydroxyurea
Added to Didanosine in Antiretroviral Naïve and Experienced HIV-1
Infected Subjects: A Randomized, Placebo-Controlled Trial, ACTG 307.
AIDS Research and Human Retroviruses. In press.
Contact:
Ian Frank, M.D.
502 Johnson Pavilion
36th St. and Hamilton Walk
University of Pennsylvania
Philadelphia, PA 19104-6073
franki@mail.med.upenn.edu
(215) 662-7419
Education:
Medical School: Dartmouth University
ID Training: University of Pennsylvania
Academic Rank: Associate Professor of Medicine
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