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Harvey
M. Friedman, M.D. (Division Chief)
Dr. Friedman is the Chief of the Infectious Diseases Division. Two projects are active in his laboratory. One project examines the role of the herpes simplex virus complement receptor and Fc receptor in viral pathogenesis. Herpes simplex virus encodes glycoproteins that help the virus escape antibody- and complement-mediated attack. Herpes simplex virus glycoprotein gC functions as a receptor for complement component C3b. By binding C3b, gC acts to turn off complement activation. Herpes simplex virus glycoproteins gE and gI together function as a receptor for the Fc domain of IgG, and reduce the effectiveness of antibody in clearing virus infection. Current studies are aimed at determining whether blocking the function of these glycoproteins improves the ability of the host to clear herpes infection. Another project examines the role of herpes simplex virus glycoprotein gE in neuronal spread. This glycoprotein is essential for transport of virus within neurons. The mechanisms by which gE mediates neuronal spread are evaluated using mouse primary neurons in vitro and a rat retinal eye infection model in vivo. Efforts derived from these basic research discoveries are underway in the laboratory to develop HSV-1 and HSV-2 vaccines.
Selected publications:
Hook LM, Huang J, Jiang M, Hodinka R, Friedman HM. Blocking antibody access to
neutralizing domains on glycoproteins involved in entry as a novel mechanism of
immune evasion by herpes simplex virus type 1 glycoproteins C and E. J Virol 82:6935
6941, 2008.
Brittle EE, Wang F, Lubinski JM, Bunte RM, Friedman HM. A Replication Competent,
Neuronal Spread Defective, Live Attenuated Herpes Simplex Virus Type-1 Vaccine. J
Virol 82:8431-8441, 2008.
Morse M, Kessler J, Albrecht S, Kim R, Thakur R, Nthobatsang R, Radisowa K,
Maunatlala C, Yang W, MacGregor RR, Friedman HM. Induced sputum improves
diagnosis of pulmonary tuberculosis in hospitalized patients in Gaborone, Botswana. Int J
Tuberc & Lung Dis 12(11):1279-1285, 2008.
Hook LM, Lubinski JM, Jiang M, Pangburn MK, Friedman HM. Herpes simplex virus type 1 and 2 glycoprotein C prevents complement-mediated neutralization induced by natural IgM antibody. J Virol 80:4038-4046, 2006.
Contact:
Harvey M. Friedman, M.D. (Division Chief)
536 Johnson Pavilion
36th Street & Hamilton Walk
Philadelphia, PA 19104-6073
hfriedma@mail.med.upenn.edu
(215) 573-8432
Education:
Medical School: McGill University
ID Training: University of Pennsylvania
Academic Rank: Professor of Medicine
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