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Rob Roy MacGregor, M.D.
Dr. MacGregor is past section chief, and a co-investigator in Penn's AIDS Clinical Trials Unit. His interests include HIV clinical research in opportunistic infections, (particularly TB, MAC and CMV) and various aspects of HIV-related epidemiology. He has studied a series of HIV DNA vaccines in collaboration with Dr. David Weiner in the Department of Pathology. He was clinical director for the initial trial of gene therapy to modify patients’ CD4 cells to resist HIV infection at Penn, now in an expanded phase. He has had several extended visits to Botswana, where he has mentored, and conducted a study of tuberculosis/HIV interaction. Other interests include antibiotic pharmacokinetics, and osteomyelitis.
Ohkusu K, Bermudez LE, Nash KA, MacGregor RR, Inderlied CB: Differential virulence of Mycobacterium avium strains isolated from HIV-infected patients with disseminated MAC disease J Infec Dis 2004;190:1347-54.
MacGregor RR, Boyer JD, Tu X, Ugen KE, Higgins TJ, Baine Y, Ciccarelli RB, Ginsberg RS, Weiner DB: Plasmid vaccination of stable HIV-positive subjects on antiviral treatment results in enhanced CD8 T-cell immunity and increased control of viral “blips”. Vaccine 2005;23:2066-73
Levine BL, Humeau LM, Boyer J, MacGregor RR, Rebello T, Lu X, Binder GK, Slepushkin V, Lemiale F, Mascola JR, Bushman FD, Dropulic B, June CH: Gene transfer in humans using a conditionally replicating lentiviral vector. PNAS 2006;103:17372-7.
Contact:
Rob Roy MacGregor, M.D.
8 Penn Tower
34th & Civic Center Blvd.
Philadelphia, PA 19104-4283
macgregr@mail.med.upenn.edu
(215) 662-3565
Education:
Medical School: Harvard University
ID Training: University of Washington/NIH
Academic Rank: Professor of Medicine
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