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Rob Roy MacGregor, M.D.

Dr. MacGregor is past section chief, and was co-investigator in Penn's AIDS Clinical Trials Unit. He is now an Emeritus Professor, but remains actively involved in many division activities. His interests include HIV clinical research in opportunistic infections, (particularly TB, MAC and CMV) and various aspects of HIV-related epidemiology. He has studied a series of HIV DNA vaccines in collaboration with Dr. David Weiner in the Department of Pathology. He was clinical director for the initial trial of gene therapy to modify patients' CD4 cells to resist HIV infection at Penn, now in an expanded phase. He has had several extended visits to Botswana, where he has mentored, and conducted a study of tuberculosis/HIV interaction. Other interests include antibiotic pharmacokinetics, and osteomyelitis.

Selected publications:

MacGregor RR, Boyer JD, Tu X, Ugen KE, Higgins TJ, Baine Y, Ciccarelli RB, Ginsberg RS, Weiner DB: Plasmid vaccination of stable HIV-positive subjects on antiviral treatment results in enhanced CD8 T-cell immunity and increased control of viral "blips". Vaccine 2005;23:2066-73.

MacGregor RR, Hafner R, Wu J, Murphy RL, Perlman DC, Bermudez LE, Inderlied CB, Picker LJ, Wallis RS, Andersen JW, Mahon LF, Koletar SL, Peterson DM, and the ACTG Protocol 341 Team: Immunological, microbiological, and clinical characteristics in HIV-infected subjects at risk for disseminated M. avium complex disease: An AACTG Study. AIDS Res Human Retrovirol 2005;21:689-95.

Levine BL, Humeau LM, Boyer J, MacGregor RR, Rebello T, Lu X, Binder GK, Slepushkin V, Lemiale F, Mascola JR, Bushman FD, Dropulic B, June CH: Gene transfer in humans using a conditionally replicating lentiviral vector. PNAS 2006;103:17372-7.

Morse M, Kessler J, Albrecht, Kim R, Thakur R, Nthobatsang R, Radisowa K, Maunatlala C, Yang W, MacGregor RR, Friedman H: Induced sputum improves diagnosis of pulmonary tuberculosis in hospitalized patients in Gaborone, Botswana Intnl J Tuberc Lung Dis (in press).

Contact:
Rob Roy MacGregor, M.D.
8 Penn Tower
34th & Civic Center Blvd.
Philadelphia, PA 19104-4283
macgregr@mail.med.upenn.edu
(215) 662-3565

Education:
Medical School: Harvard University
ID Training: University of Washington/NIH
Academic Rank: Emeritus Professor of Medicine