Laboratory studies how lymphocytes make decisions. One such important
decision is which type of helper T cell will predominate in response
to an infection. We use diverse experimental approaches ranging from
infectious disease models (such as challenge with Leishmania major)
to basic studies into novel aspects of the control of gene expression.
Our findings have implications for understanding how the genome is regulated
during evolution and how cells make many decisions, from early embryogensis
through infectious diseases in adults.
AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DM, Kung
AL, Cereb N, Tao, T-P, Yang SY, Reiner SL. Role of T-bet in Commitment
of TH1 cells before IL-12-dependent selection. Science, 292: 1907-1910,
A.C., Hutchins, A.S., High, F.A., Lee, H.W., Sykes, K.J., Chodosh, L.A.
and Reiner, S.L. Hlx is induced by and genetically interacts with T-bet
to promote heritable TH1 gene induction. Nature Immunology, 3: 652-658,
A.S., Mullen, A.C., Lee, H.W., Sykes, K.J., High, F.A., Hendrich, Reiner,
S.L. Gene silencing quantitatively controls the function of a developmental
trans-activator. Molecular Cell, 10: 81-91, 2002.
Steven L. Reiner, M.D.
BRB II/III, Room 414
421 Curie Blvd.
Philadelphia, PA 19104-6160
Medical School: Duke University
ID Training: University of California, San Francisco
Academic Rank: Professor of Medicine