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Steven Reiner, M.D. The Reiner Laboratory studies how lymphocytes make decisions. One such important decision is which type of helper T cell will predominate in response to an infection. We use diverse experimental approaches ranging from infectious disease models (such as challenge with Leishmania major) to basic studies into novel aspects of the control of gene expression. Our findings have implications for understanding how the genome is regulated during evolution and how cells make many decisions, from early embryogensis through infectious diseases in adults. Mullen AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DM, Kung AL, Cereb N, Tao, T-P, Yang SY, Reiner SL. Role of T-bet in Commitment of TH1 cells before IL-12-dependent selection. Science, 292: 1907-1910, 2001. Mullen, A.C., Hutchins, A.S., High, F.A., Lee, H.W., Sykes, K.J., Chodosh, L.A. and Reiner, S.L. Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction. Nature Immunology, 3: 652-658, 2002. Hutchins,
A.S., Mullen, A.C., Lee, H.W., Sykes, K.J., High, F.A., Hendrich, Reiner,
S.L. Gene silencing quantitatively controls the function of a developmental
trans-activator. Molecular Cell, 10: 81-91, 2002. Contact:
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