Peter Francis Davies
Robinette Foundation Professor of Cardiovascular Medicine
Director, Institute for Medicine & Engineering
Professor of Pathology & Laboratory Medicine
Professor of Bioengineering
Director, NIH Training Grant in Multidisciplinary Cardiovascular Biology
Co-Director, Penn HHMI-NIH Interfaces Program in Biomedical Imaging
Co-Director, Research Program in Biotechnology
Cardiovascular Research Institute Member
Advisory Board Member, Institute for Translational Medicine and
Therapeutics
3340 Smith Walk
Philadelphia, PA 19104-6383
Fax: (215) 573-6815
pfd@pobox.upenn.edu
BSc. (Chemistry/Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, UK, 1969.
MSc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
Cambridge University, UK, 1975.
Description of Research Expertise
Research Interests
Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Stents, Cytoskeletal and membrane biophysics.
Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, endothelial genomics.
Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics and computational fluid dynamics. Stent design.
Rotation Projects
Please discuss with Dr. Davies.
Lab Personnel:
Juan Jimenez PhD, Postdoctoral Fellow
Yun Fang PhD, Postdoctoral Fellow
Jennifer Clark PhD, Postdoctoral Fellow
Technical Staff: Congzhu Shi PhD,
Prioty Islam, Vagelos Scholar (Chem/Biochem)
Hadi Kaakour, Vagelos Scholar (Chem/Biochem)
Varesh Prasad, BSE Trainee
Description of Other Expertise
Biophysics; Lipid metabolism; microRNA; genomicsDr. Davies is interested in quantitative aspects of vascular pathophysiology especially the influence of hemodynamics on endothelial phenotype in vivo and in vitro.
Selected Recent Publications
Davies, P.F. 2009. Endothelial
transcriptome profiles in vivo in complex arterial flow fields.
Annals Biomed. Eng. 36:563-571.
Jimenez, J.M. and Davies,
P.F. 2009. Hemodynamically-driven stent strut design. Annals
Biomed. Eng. 37:1483-95.
Civelek, M., Manduchi, E.,
Riley, R., Stoeckert, C.J., Davies, P.F. 2009. Chronic endoplasmic
reticulum (ER)-stress activates unfolded protein response (UPR)
in arterial endothelium in regions of susceptibility to atherosclerosis.
Circ. Research, 105:453-461.
Davies, P.F. 2009. Hemodynamic
Shear Stress and the Endothelium in Cardiovascular Pathophysiology.
Nature Clin. Pract. Cardiovasc. Med. 6:16-26.
Helmke, B.P., Davies, P.F.
2010. Imaging Live Cells under Mechanical Stress. In: Live
Cell Imaging: A Laboratory Manual. 2nd Edition. Edited: Goldman,
R.L., Swedlow, J., and Spector, D.L., Publ. Cold Spring Harbor
Laboratory Press, pp 641-658.
Davies, P.F., Helmke, B.P.
2010. Endothelial Mechanotransduction. In: 'Cellular Mechanotransduction:
Diverse Perspectives from Molecules to Tissue', Eds. Mofrad,
R.K. and Kamm, R.D. Cambridge University Press. Chapt. 2. pp20-60.
Civelek, M., Grant, GR, Irolla,
CR, Shi C, Riley R, Chiesa O, Stoeckert CJ, Karanian JW, Pritchard
WF, Davies PF. 2010. Pre-lesional arterial endothelial
responses in hypercholesterolemia: Universal ATP-Binding Cassette
A1 (ABCA1) upregulation contrasts with region-specific gene expression
in vivo. Am. J. Physiol. (Heart and Circulatory). 298:163-170.
Jimenez JM, Davies PF.
2010. Design implications for endovascular stents and the endothelium.
In: Hemodynamics & Mechanobiology of Endothelium Ed: Hsiai
J, Blackman B, Jo H. Publ: World Scientific Press. pp329-349.
Guerraty, M.A, Grant, G.R.,
Karanian, J.W., Chiesa, O.A., Pritchard, W.P., Davies, P.F.
2010. Hypercholesterolemia induces side-specific phenotype changes
and PPARg pathway activation in swine aortic valve endothelium.
Arterio. Thromb. Vasc. Biol. 30:225-231.
Davies
PF and Civelek M. 2010. Commentary: Site-specific athero-susceptible
endothelial phenotype shows prominent adaptive ER-stress and unfolded
protein responses in vivo. International Atherosclerosis Society
(IAS) Website Commentary.http://www.athero.org/commentaries/comm978.asp.
Davies PF, Civelek M, Fang Y, Guerraty
MA, Passerini AG. 2010. Endothelial Heterogeneity associated
with Regional Athero-susceptibility and Adaptation to Disturbed
Blood Flow in vivo. (Special Issue: Under-recognized Significance
of Endothelial Heterogeneity). Semin Thromb Hemost 36:265-275.
Fang, Y., Shi, C., Manduchi,
E., Civelek, M., Davies, P.F. 2010. MicroRNA-10a regulation
of pro-inflammatory phenotype in athero-susceptible endothelium
in vivo and in vitro. Proc. Natl. Acad Sci. USA. 107:13450-13455.
Waters SL, Alastruey J, Beard DA, Bovendeerd PH, Davies PF, Jayaraman G, Jensen OE, Lee J, Parker KH, Popel AS, Secomb TW, Siebes M, Sherwin SJ, Shipley RJ, Smith NP, van de Vosse FN. 2011. Theoretical Models for Coronary Vascular Biomechanics: Progress and Challenges. Progr. Biophys. Mol. Biol. 104:49-76.
Civelek, M., Manduchi, E., Stoeckert, C.J., Davies, P.F. 2011. Discovery approaches to the Unfolded Protein Response in athero-susceptible endothelium in vivo. Methods Enzymol. 489:109-127.
Davies, P.F., Civelek, M.
2011. Endothelial reticulum stress, redox and a pro-inflammatory
environment in athero-susceptible endothelium in vivo at sites
of complex hemodynamic shear stress, Antioxid. Redox Signal.
In Press.
Guerraty, M.A., Grant, G.,
Pritchard, W.F., Karanian, J.W., Chiesa, O.A., Davies, P.F.
2011. Site-specific expression of activated leukocyte adhesion
molecule (ALCAM/CD166) in patho-susceptible regions of swine aortic
valve endothelium. J. Heart Valve Disease. 20:165-167.
Davies, P.F., Guerraty,
M.A. 2011. Getting physical with the aortic valve. Arterio.
Thromb. Vasc. Biol. 31:474-475.
Civelek,
M., Manduchi, E., Stoeckert CJ, Chiesa O, Karanian JW, Pritchard
WF, Davies PF. 2011. Coronary artery endothelial transcriptome
in vivo: Identification of ER-stress and enhanced ROS
by gene connectivity nertwork analysis. Circulation Cardiovascular
Genetics. 4:243-252..
Last updated: 07/14/2011