Wistar Institute for Anatomy and Biology The Wistar Institute is the oldest of America's independent non-profit institutions dedicated to biomedical research and training. Located adjacent to the Medical Center, the Wistar employs more than 60 full-time research scientists. Additionally, as many as 100 post-doctoral scientists from around the world work at the Institute at any given period. The main themes of research include cancer biology, immunology, genetics, the molecular biology of HIV, and developmental biology. The Pulmonary Division has developed particularly strong ties to the Wistar, with several of our faculty holding joint appointments and Wistar faculty actively participating in training of research fellows. Penn Center for Sleep Disorders The Penn Center for Sleep Disorders draws on the expertise of physicians from pulmonary medicine, neurology, otorhinolaryngology, maxillofacial surgery, and psychiatry. The Center evaluates patients with a wide range of sleep disorders, including sleep apnea syndromes, narcolepsy, insomnia, and movement disorders. Under the overall direction of Allan Pack, Penn has been designated a Specialized Center for Research (SCOR) by the NIH for fundamental and applied research on sleep physiology and sleep disorded breathing. Richard Schwab, Clinical Director of the Center, has developed novel radiographic techniques to image the upper airway, and has applied these to the investigation of mechanisms underlying airway compromise in obstructive sleep apnea. State-of-the-art surgical techniques, including laser surgery and mandibular reconstruction, complement the conventional use of CPAP in the treatment of selected patients. Institute for Environmental Medicine Founded in 1968, the Institute for Environmental Medicine initially focused on studies related to underwater and aerospace environments. In 1985, Dr. Aron Fisher assumed leadership of the Institute and broadened the scope of research to include investigations of the cellular and molecular biology and biochemistry of the lung under normal as well as adverse conditions. Current research themes include surfactant production and metabolism, pulmonary oxygen toxicity, ischemia-reperfusion injury to the lung, therapeutic effects of hyperbaric oxygen, and pulmonary injury induced by smoke inhalation. The Institute offers fellows with a particular interest in these areas the opportunity to create a research program appropriate to their individual needs, under the mentorship of Institute investigators. Center for Epidemiology and Biostatistics The mission of this interdisciplinary and interdepartmental center is to improve the health of the public: 1) by linking epidemiology, biostatistics, and clinical medicine, and 2) by bringing epidemiological research methods to clinical research, clinical insight to epidemiological research, and an understanding of research methodology to clinical medicine. Center faculty, trainees, and staff are currently engaged in more than 135 research projects, both hospital-based and community-based. Center staff also serve as consultants to the private and public sectors on issues of public health. Paul Lanken, Jason Christie and Andrea Apter of the Pulmonary, Allergy and Critical Care Division are Senior Scholars in the Center. Each year, one of more fellows in the division, receive a Master's Degree in Clinical Epidemiology under the supervision of Center faculty. Leonard Davis Institute This internationally-renowned institute is a joint initiative of the School of Medicine and the Wharton School of Business at Penn. The Institute conducts research on the economics and organization of medical services and analyzes current or proposed health care policies. Through the Institute, physician trainees can earn a Masters of Business Administration or a PhD in health economics. University of Pennsylvania Cancer Center This Center is dedicated to providing the most advanced and innovative programs in cancer care, research, and education. The Penn Cancer Center, founded in 1973, is one of twenty-seven Comprehensive Cancer Centers in the United States formally approved and designated by the National Cancer Institute. The Cancer Center includes a nationally-recognized faculty of over 300 clinicians and scientists from 30 clinical and basic science departments of the University of Pennsylvania. Included among many specialized programs is the Penn Center for Lung Cancer and Related Disorders. Center for Bioethics The mission of this interdisciplinary, interprofessional Center, headed by Arthur Caplan, is to advance scholarly and public understanding of ethical, legal, social and public policy issues in health care. Center faculty carry appointments in philosophy, medicine, nursing, law, social science, public policy, the Wharton School, communications, and the allied health professions. Faculty teach courses and seminars in the Medical School, in other professional schools at Penn and in various graduate departments of the University. Center faculty, conduct research on key issues in bioethics, and are especially concerned with ethical issues in genetics, pediatrics, health policy, human experimentation and long-term care. Members of the Pulmonary Division including Paul Lanken and John Hansen-Flaschen have long-standing interests in the ethics of terminal care in intensive care units. Institute on Aging Since its inception as the Center for Aging in 1978, this Institute has aimed to improve understanding of the aging process and the health status of older people through interdisciplinary research, education and patient care. The many research programs of the Institute include epidemiological studies of sleep apnea in nursing home populations. Nalaka Gooneratne, a pulmonary and sleep medicine physician, serves as liaison to the Institute for the Pulmonary Division. Cardiothoracic Imaging Research Center The Department of Radiology at Penn has a long tradition of excellence in thoracic imaging. The Department has multiple magnetic resonance imaging and computed tomography scanners with ultrafast capabilities. The Cardiothoracic Imaging Research Center provides computer resources for cardiothoracic image reconstruction and data analysis. Center-supported research projects involve a wide spectrum of cardiopulmonary themes, including three-dimensional reconstruction of the upper airway in patients with sleep apnea, and functional lung imaging using CT and novel MRI techniques under the direction of Richard Schwab and David Lipson of the Pulmonary Division.