Assistant Professor of Medicine

Pulmonary, Allergy & Critical Care Division
Presbyterian Medical Canter
PHI, 1st floor
Philadelphia, PA 19104-6160
tel.: (215) 662-8766
fax.: (215) 243-3265
email: alazaar@mail.med.upenn.edu

Education:

MD: New York University

Residency: Boston City Hospital

Research Registrar: Charing Cross Hospital, London, England

Fellowship: Hospital of the University of Pennsylvania

My research interest focuses on the immunobiology of airway smooth muscle as it relates to the pathogenesis of asthma, particularly the role of VEGF and related molecules on smooth muscle contractility and airway inflammation.

Lazaar AL, Sweeney LE, MacDonald AJ, Cooray H, Alexis NE, Fuhr R, Tal-Singer R.  SB-656933, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in humans. Am. J. Respir. Crit. Care Med., 179: A6181, 2009.

Esther CR and AL Lazaar.  Airway Adenosine Is Elevated in COPD and Correlates with Disease Severity.  Am. J. Respir. Crit. Care Med., 179: A3764, 2009.

Lazaar AL and RA Panettieri. Airway smooth muscle as a regulator of immune responses and bronchomotor tone.  Clin Chest Med 27:53-69, 2006

Lazaar AL and RA Panettieri. Airway smooth muscle: a modulator of airway remodeling in asthma.  J Allergy Clin Immunol. 116:488-495, 2005

Kazi AS, Lotfi S, Goncharova EA, Tliba O, Amrani Y, Krymskaya VP, Lazaar AL. Vascular endothelial growth factor-induced secretion of fibronectin is ERK-dependent. Am J Physiol (Lung) 286:L539-545, 2004.

Lazaar AL, Plotnick M, Kucich U, Crichton I, Das SKP, Kane S, Lotfi S, Rosenbloom J, Panettieri RA, Schechter NM, Puré E. Mast cell chymase modifies cell-matrix interactions and inhibits mitogen-induced proliferation of human airway smooth muscle cells. J Immunol. 169:1014-1020, 2002.

Lazaar AL, Krymskaya VP, Das SKP. VCAM-1 activates phosphatidylinositol 3-kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells. J. Immunol 166:155-161, 2001.

Lazaar AL, Amrani Y, Hsu J, Panettieri RA, Fanslow WC, Albelda SM, Puré E. CD40-mediated signal transduction in human airway smooth muscle. J. Immunol 161:3120-3127, 1998.

Lazaar AL, Albelda SM, Pilewski JM, Brennan B, Puré E., Panettieri RA. T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis. J. Exp. Med. 180:807-816, 1994.