Chirag V. Shah, M.D., M.S.C.E.

Assistant Professor in Medicine

Pulmonary, Allergy, & Critical Care Division
3400 Spruce Street
844 W. Gates Bldg
Philadelphia, PA 19104
tel.: (215) 662-7056
fax: (215) 614-0689
email: chirag.shah@uphs.upenn.edu

Education:

M.D. - University of Missouri at Kansas City

Residency - Washington University School of Medicine & Barnes-Jewish Hospital

Fellowship - University of Pennsylvania School of Medicine

M.S. Clinical Epidemiology – University of Pennsylvania School of Medicine

Dr. Shah’ interests are in translational research studies on the risk, pathogenesis, and outcome of organ failures (e.g., ARDS) in sepsis.  Dr. Shah has developed a collaborative research infrastructure with the Emergency Department, Institute of Translational Medicine & Therapeutics, Penn Coagulation Laboratory, and the Center for Clinical Epidemiology & Biostatistics.  Currently funded on an NIH Career Development Award (K23), Dr. Shah’s directs a prospective cohort study of patients admitted from the Penn ED with severe sepsis and follows them for development of ARDS, AKI, and death. 

The Specific Aims of his study are:

Defining clinical risk factors for sepsis-related ARDS

Developing and validating a predictive index for ARDS

Identification of novel plasma biomarkers related to disordered coagulation and impaired fibrinolysis (e.g., PAI-1, tissue factor, Prot C, uPA, endocan, a-defensin) that may help risk stratify patients and shed light on the mechanisms of ARDS development in sepsis

Other interests of Dr. Shah include mechanical ventilation in ARDS, role of recruitment maneuvers, and alternative modes of ventilation (e.g., APRV).

Cooke CR, Shah CV, Gallop R, Bellamy S, Ancukiewicsz M, Eisner MD, Lanken PN, Localio AR, Christie JD. A Simplified Clinical Predictive Index for Objective Estimates of Mortality in Acute Lung Injury. Crit Care Med 2009;00:000-000 (In press)

Shah CV, Lanken PN, Kahn JM, Gallop R, Bellamy S, Localio AR, Finkel B, Gracias V, Fuchs BD, Christie JD.  Impact of Acute Lung Injury on Hospital Mortality in Critically Ill Trauma Patients. Crit Care Med 2008;36(8):2309-2315.

Netzer G, Shah CV, Iwashyna TJ, Lanken PN, Finkel B, Fuchs B, Guo W, Christie JD.  Association of Red Cell Transfusion with Mortality in Patients with Acute Lung Injury. Chest 2007;132:1116-1123.

Shah C, Kollef MH. Endotracheal Tube Intraluminal Volume Loss Among Mechanically Ventilated Patients. Crit Care Med. 32(1):120-5, 2004 Jan.

revised 8/09