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Penn Presbyterian Medical Center
Mutch Building, 5th Floor
51 N. 39th Street
Philadelphia, PA 19104
email: david.larosa@uphs.upenn.edu
- MD: State University of New York Downstate College
of Medicine
- Residency: Hospital of the University of Pennsylvania
- Fellowship: Hospital of the University of Pennsylvania
Dr. LaRosa completed a three-year fellowship in the medical
subspecialty of allergy and clinical immunology and is now
junior faculty at the University of Pennsylvania School
of Medicine. His clinical interests include the evaluation
and management of patients with primary immunodeficiency
and allergic hypersensitivity disorders. His research interests
include using mouse models to better understand the factors
that shape the immune response to microbes. Dr. LaRosa has
been awarded The Will Rodgers Institute Research Fellowship
to support his development as a clinician-scientist. In
addition, he has recently received a Mentored Clinician-Scientist
Development Award from the National Institute of Allergy
and Infectious Diseases.
LaRosa DF, and Orange JS. Chapter 1. Lymphocytes. The Journal
of Allergy and Clinical Immunology. 2008 Feb; Suppl Mini-Primer,
In press.
LaRosa DF, Rahman AH, and Turka LA. Brief Reviews: The innate
immune system in allograft rejection and tolerance. The Journal
of Immunology. 2007; 178:7503-7509.
Wallace A*, LaRosa DF*, Kapoor V, Sun J, Cheng GJ, Jessar
A, Blouin A, Ching L, and Albelda SM. The vascular disrupting
agent, 5,6 di-methylxanthenone-4-acetic acid (DMXAA), directly
activates dendritic cells through a MyD88-indpendent mechanism
and generates anti-tumor cytotoxic T-lymphocytes. Cancer Research.
2007; In press. *Co-first authors
LaRosa DF, Gelman AE, Rahman AH, Zhang J, Turka LA, and
Walsh PT. CpG DNA inhibits CD4+CD25+ Treg suppression through
direct MyD88-dependent costimulation of effector CD4+ T cells.
Immunology Letters. 2007; 108(2):183-188.
Narula S, LaRosa DF, Kamoun M, Dalmau J, and Levinson AI.
Progressive multifocal leukoencephalopathy in a patient with
common variable immunodeficiency and abnormal CD8+ T cell
subset distribution. Annals of Allergy, Asthma & Immunology.
2007; 98(5):483-489.
Gelman AE, LaRosa DF, Zhang J, Walsh PT, Choi Y, Sunyer
JO, and Turka LA. The Adaptor Molecule MyD88 Activates PI-3
Kinase Signaling in CD4(+) T Cells and Enables CpG Oligodeoxynucleotide-Mediated
Costimulation. Immunity. 2006; 25:783-793.
Taylor DK, Walsh PT, LaRosa DF, Zhang J, Burchill MA, Farrar
MA, and Turka LA. Constitutive activation of STAT5 supersedes
the requirement for cytokine and TCR engagement of CD4+ T
Cells in steady-state homeostasis. The Journal of Immunology.
2006; 177(4):2216-2223.
Anderson AL, Sporici R, Lambris J, LaRosa D, and Levinson
AI. Pathogenesis of B cell superantigen induced immune complex
mediated inflammation. Infection and Immunity. 2006; 74(2):1196-203.
revised 7/07
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