Frank T. Leone, M.D., MS

Associate Professor of Medicine

University of Pennsylvania Medical Center
Pulmonary, Allergy & Critical Care Division
Airways Biology Initiative
Presbyterian Medical Center - 1 PHI
51 N. 39th Street
Philadelphia, PA 19104
tel.: (215) 662-8766
fax.: (215) 243-3265
email: frank.tleone@uphs.upenn.edu

Education:

• M.D.: University of Pittsburgh School of Medicine
• Residency: Thomas Jefferson University
• Fellowship: Thomas Jefferson University


Dr. Leone received his medical degree from the University of Pittsburgh School of Medicine and completed his postgraduate training in internal medicine and subsequently in pulmonary and critical care medicine at Thomas Jefferson University Hospital. He also received his masters degree in clinical epidemiology and biostatistics from the University of Pennsylvania School of Medicine. Dr. Leone directs Penn's Comprehensive Smoking Treatment Program, a clinical program of the Penn Lung Center, located initially at Penn Presbyterian Medical Center. The new program provides state-of-the-art and individualized treatment to smokers, including those with comorbidities. In the near future, the Smoking Treatment Program will also serve patients at the Perelman Center for Advanced Medicine, opening in early 2008, and Penn Medicine at Radnor. Dr. Leone's scholarship focuses on investigating treatment strategies for tobacco use disorder and the effects of smoke on airway biology. Dr. Leone is a member of several professional and scientific societies, including the Society for Research on Nicotine and Tobacco, and has served as President of the Board of Directors of the American Lung Association of Pennsylvania. He has served the Commonwealth of Pennsylvania as a legislative appointee to the Governor's Tobacco Use Prevention and Cessation Advisory Committee since 2001. Dr. Leone has been invited to speak at numerous lectures on topics of smoking treatment and pulmonary medicine, and has been published in a variety of clinical and research journals. He is board certified in pulmonary and critical care medicine.

Representative publications:

Leone FT, Evers-Casey S, Veloski J, Patkar A, Kanzleiter L for the Pennsylvania Continuum of Tobacco Education workgroup.  Short, intermediate, and long-term outcomes of Pennsylvania’s Continuum of Tobacco Education Project pilot Nic Tob Res 2009; 11: 387-393.

Mastronarde J, Antonisen N, Castro M, Holbrook J, Leone FT, Teague G, and Wise R for the American Lung Association Asthma Clinical Research Centers.  Efficacy of Esomeprazole for Treatment of Poorly Controlled Asthma; a Randomized Controlled Trial.  New England Journal of Medicine 2009; 360: 1487-1499

Schnoll RA, Wileyto EP, Pinto A, Leone FT, Gariti P, Siegel S, Perkins K, Dackis C, Berrettini W, Lerman C.  A placebo-controlled trial of modafinil for nicotine dependence.  Drug Alc Dep. 2008; 98: 86-93.

Niaura R, Hays JT, Jorenby D, Leone FT, Pappas JE, Reeves K, Williams K, Billing C.  The efficacy and safety of varenicline for smoking cessation using a flexible dosing strategy in adult smokers.  Curr Med Res Opin. 2008; 24: 1931-1941.

Lazarus SC. Chinchilli VM. Rollings NJ. Boushey HA. Cherniack R. Craig TJ. Deykin A. DiMango E. Fish JE. Ford JG. Israel E. Kiley J. Kraft M. Lemanske RF Jr. Leone FT. Martin RJ. Pesola GR. Peters SP. Sorkness CA. Szefler SJ. Wechsler ME. Fahy JV. National Heart Lung and Blood Institute’s Asthma Clinical Research Network.  Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma.  Am J Resp Crit Care Med 2007;175(8):783-90.

Peters S, Anthonisen N, Castro M, Holbrook J, Irvin C, Smith L, Wise R for the American Lung Association Asthma Clinical Research Network Investigators (Leone FT).  Randomized Comparison of Strategies for Reducing Treatment in Mild Persistent Asthma.  New England Journal of Medicine 2007; 356(20): 2027-2039.

Patkar A, Mannelli P, Peindl K, Murray H, Meier B, Leone FT.  Changes in tobacco smoking following treatment for cocaine dependence.  Am J Drug Alc Abuse. 2006; 32: 135 – 148.

Boushey H, Sorkness C, King T, Sullivan S, Fahy J, Lazarus S, Chinchilli V, Craig T, Dimango E, Deykin A, Fagan J, Fish J, Ford J, Kraft M, Kunselman S, Leone FT, Lemanske R, Martin R, Mauger E, Pesola G, Peters S, Rollings N, Szefler S, Wechsler M, Israel E.  Daily vs. as-needed corticosteroids for mild persistent asthma.  New England Journal of Medicine. 2005; 352 (15): 1519 – 1528.

Patkar A, Batra V, Mannelli P, Evers-Casey S, Vergare M, Leone FT.  Medical symptoms associated with tobacco smoking with and without marijuana use among crack cocaine abusers.  Am J Addict 2005; 14: 43-53.

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