Jason D. Christie, MD

Assistant Professor of Medicine
Assistant Professor of Epidemiology

University of Pennsylvania Medical Center
Pulmonary, Allergy & Critical Care Division
Blockley Hall, Rm. 719
422 Guardian Drive
Philadelphia, PA 19104-6160
tel.: (215) 573-3209
fax: (215) 573-0198
email: jchristi@mail.med.upenn.edu

Education:

BS: Brown University (Chemistry)

MD: Columbia College of Physicians and Surgeons

Fellowship: Hospital of the University of Pennsylvania

M.S.C.E.: University of Pennsylvania

Jason D. Christie, M.D., M.S. is the Section Chief of Medical Critical Care.  He is currently Assistant Professor of Medicine in the Department of Pulmonary/Critical Care Medicine and Assistant Professor of Epidemiology in the Department of Biostatistics and Epidemiology at the University of Pennsylvania.  He is a Senior Scholar in the Center for Clinical Epidemiology and Biostatistics, and the Director of Clinical Research in the Pulmonary Division. His career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury (ALI) in the transplant and non-transplant human populations.

Currently, he has extramural funding to study the role of oxidative stress, coagulation/fibrinolysis, and inflammatory pathways in acute lung injury following lung transplantation (termed primary graft dysfunction). He has active research on somatic genetic variation, gene expression, and protein biomarkers in the etiology and pathogenesis of acute lung injury in the transplant, sepsis, and trauma populations. His research brings together clinicians, basic scientists, epidemiologists, and statisticians to build multidisciplinary studies of acute lung injury research.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation. This group is funded by two R01 grants from NHLBI, one focusing on genetic risks and a second focusing on plasma protein biomarkers as risk factors for ALI following lung transplantation (termed primary graft dysfunction).  In addition, he is a project leader in the Clinical Trials in Organ Transplantation consortium, funded through NIH. The goals of this project are to test the association between inflammatory gene mRNA expression in the donor and acute lung injury following the lung transplantation, as well as link early mRNA profiles with acute rejection occurring during the first year.  Furthermore, Dr. Christie is the Associate Medical Director of the UNOS/ISHLT lung transplant registry.

Dr. Christie is a project leader on a program project grant (Aron Fisher, PI) investigating genetic risks for ALI following trauma. He recently formed a multicenter collaboration, called the Trauma ALI SNP Consortium (TASC) to perform genome wide genetic association studiesof ALI risk and outcomes.  In addition, through the ARDSnet, he is currently conducting an ancillary study evaluating the long-term cognitive and neurological outcomes following ALI/ARDS.

Representative Publications:

Christie JD, Robinson N, Ware L, Plotnick M, DeAndrade J, Lama V, Milstone A, Orens J, Weinacker A, DeMissie E, Bellamy S, Kawut S, for the Lung Transplant Outcomes Group. Association Of Protein C And Type-1 Plasminogen Activator Inhibitor With Primary Graft Dysfunction Am J Respir Crit Care Med 2007 Jan 1;175(1):69-74.

Christie JD*, Marzec J*, Reddy S, Jedlicka AE, Vuong H, Lanken PN, Aplenc R, Cho HY, Kleeberger SR. Functional Polymorphisms in the Transcription Factor NRF2 are Associated with Increased Risk of Acute Lung Injury. FASEB Journal 2007 Jul;21(9):2237-46. (* indicates equal contribution to the work)

Christie JD, Robinson N, Ware L, Plotnick M, DeAndrade J, Lama V, Milstone A, Orens J, Weinacker A, DeMissie E, Bellamy S, Kawut S, for the Lung Transplant Outcomes Group. Association Of Protein C And Type-1 Plasminogen Activator Inhibitor With Primary Graft Dysfunction Am J Respir Crit Care Med 2006 00:000-000 (in press)

Christie JD, Kotloff RM , Ahya VN, Tino G, Pocchetino A, Gaughan C, DeMissie E, Kimmel SE. The Effect of Primary Graft Dysfunction on Survival Following Lung Transplantation. Am J Respir Crit Care Med 2005 171(11):1312-1316.

Christie JD, Sager J, Kimmel SE, Ahya V, Gaughan C, Blumenthal N, Kotloff RM. Impact of Primary Graft Failure on Outcomes Following Lung Transplantation. Chest 2005, 127(1):161-5

Christie JD, VanRaemdonck D, de Perrot M, Barr M, Keshavjee S, Arcasoy S, Orens J. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction. Part I: Introduction and Methods. Journal of Heart and Lung Transplantation 2005 (10):1451-3

Christie JD, Carby M, Bag R, Corris P, Hertz M, Weill D. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction. Part II: Definition - Consensus Statement of the International Society for Heart and Lung Transplantation. Journal of Heart and Lung Transplantation 2005 (10):1454-9

Christie JD, Kotloff RM , Pocchetino A, Arcasoy SM, Blumenthal NP, Landis JR, Kimmel SE. Clinical Risk Factors For Development Of Primary Graft Failure Following Lung Transplantation. CHEST 2003; 124: 1232-1241.

Christie JD, Plotkin R, Taichman D, Shull W, Hansen-Flaschen J, Shea JA, Hopkins RO. Formation and Validation of a Telephone Battery to Assess Cognitive Function in ARDS Survivors. Journal of Critical Care 21(2):125-132.

Christie JD, Marzec J, Reddy S, Jedlicka AE, Vuong H, Lanken PN, Aplenc R, Cho HY, Kleeberger SR. Functional Polymorphisms in the Transcription Factor NRF2 are Associated with Increased Risk of Acute Lung Injury (Submitted)

Christie JD, Aplenc RA, Vachani A, Lanken PN, Foulkes A, Gaughan C, Gallup R, Albelda SM, Landis JR, Rebbeck T. Genetic Variation In The Catalase Gene And The Risk Of Acute Lung Injury Following Major Trauma. (Submitted)

Christie JD, Aplenc R, DeAndrade J, Kawut S, Milstone A, Weinacker A, Zhou L, Mazzotta J, DeMissie, Orens J. Donor Glutathione S-Transferase Genotype is Associated with Primary Graft Dysfunction Following Lung Transplantation. (Submitted)

Chapters and Editorials

Lung Transplantation:

Hoffman SA, Wang L, Shah CV, Ahya VN, Pochettino A, Olthoff K, Shaked A, Wille K, Lama V, Milstone A, Ware LB, Orens J, Weinacker A, Demissie E, Bellamy S, Kawut SM, Hancock WW, Christie JD for the Lung Transplant Outcomes Group: Plasma Cytokines and Chemokines in Primary Graft Dysfunction Post-Lung Transplantation. American Journal of Transplantation 9(2): 389-396, Feb 2009.

Iwata T, Philipovskiy A, Fisher AJ, Presson RG, Chiyo M, Lee J, Mickler E, Smith GN, Petrache I,  Brand DB, Burlingham W, Gopalakrishnan B,  Greenspan DS, David S. Wilkes*, Christie JD* (Co-senior authors due to equal contributions): Anti-type V Collagen Humoral Immunity in Lung TransplantPrimary Graft Dysfunction. Journal of Immunology 181: 5738-5747, October 2008.

Covarrubias MB, Ware LB, Kawut S, DeAndrade J, Milstone A, Weinacker A, Lama V, Christie JD: Plasma Intercellular Adhesion Molecule-1  (ICAM) and Von Willebrand Factor (VWF) in Primary Graft Dysfunction Following Lung Transplantation. American Journal of Transplantation 7(11): 2573-8, Nov 2007

Christie JD, Robinson N, Ware L, Plotnick M, DeAndrade J, Lama V, Milstone A, Orens J, Weinacker A, DeMissie E, Bellamy S, Kawut S, for the Lung Transplant Outcomes Group. Association Of Protein C And Type-1 Plasminogen Activator Inhibitor With Primary Graft Dysfunction Am J Respir Crit Care Med 2007 Jan 1;175(1):69-74.

Christie JD, Kotloff RM , Ahya VN, Tino G, Pocchetino A, Gaughan C, DeMissie E, Kimmel SE. The Effect of Primary Graft Dysfunction on Survival Following Lung Transplantation. Am J Respir Crit Care Med 2005 171(11):1312-1316.

Critical Care:

Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD: Serum Lactate is Associated with Mortality in Severe Sepsis Independent of Organ Failure and Shock. Critical Care Medicine 37(5): 1670-7, May 2009.

Christie JD, Ma SF, Aplenc R, Li M, Lanken PN, Fuchs B, Albelda SM, Flores C, Garcia JGN: Variation in the MYLK Gene is Associated with Development of Acute Lung Injury Following Major Trauma. Critical Care Medicine 36(10): 2794-800, October 2008.

Shah CV, Localio AR, Lanken PN, Kahn JM, Bellamy S, Gallop R, Finkel B, Gracias V, Fuchs BD, Christie JD: Impact of Acute Lung Injury on Mortality in Critically Ill Trauma Patients   Critical Care Medicine 36(8): 2309-15, August 2008.

Netzer G, Shah CV, Iwashyna TJ, Lanken PN, Finkel B, Fuchs B, Guo W, Christie JD: Red Cell Transfusion is a Risk Factor for Death After Acute Lung Injury. Chest 132(4): 1116-23, Oct 2007.p> Christie JD*, Marzec J*, Reddy S, Jedlicka AE, Vuong H, Lanken PN, Aplenc R, Cho HY, Kleeberger SR. Functional Polymorphisms in the Transcription Factor NRF2 are Associated with Increased Risk of Acute Lung Injury. FASEB Journal 2007 Jul;21(9):2237-46. (* indicates equal contribution to the work)