Jason D. Christie, M.D., M.S. is Assistant Professor of
Medicine in the Department of Pulmonary/Critical Care Medicine
and Assistant Professor of Epidemiology in the Department
of Biostatistics and Epidemiology at the University of Pennsylvania.
He is currently a Senior Scholar in the Center for Clinical
Epidemiology and Biostatistics, and the Director of Clinical
Research in the Pulmonary Division. His career is focused
on translational research studies of the risks, pathogenesis,
treatment, and outcomes of ALI/ARDS in the transplant and
non-transplant human populations.
Dr. Christie's career is focused on translational research
studies of the risks, pathogenesis, treatment, and outcomes
of ALI/ARDS in the transplant and non-transplant human populations.
Currently, he has extramural funding to study the role of
oxidative stress, coagulation/fibrinolysis, and inflammatory
pathways in acute lung injury following lung transplantation
(termed primary graft dysfunction). He has active research
on somatic genetic variation, gene expression, and protein
biomarkers in the etiology and pathogenesis of acute lung
injury in the transplant, sepsis, and trauma populations.
His research brings together clinicians, basic scientists,
epidemiologists, and statisticians to build multidisciplinary
studies of acute lung injury research.
Dr. Christie is the founder of the lung transplant outcomes
group (LTOG), which is a multicentered cohort study the
etiology and pathogenesis of acute lung injury following
lung transplantation. The group recently received RO1 funding
to study oxidant stress genes in ALI pathogenesis, with
Dr. Christie as PI. In addition, he is a project leader
in the Clinical Trials in Organ Transplantation consortium,
funded through NIH. The goals of this project are to test
the association between inflammatory gene mRNA expression
in the donor and acute lung injury following the lung transplantation.
Dr. Christie is a project leader on a program project grant
investigating oxidant stress genes in the etiology and pathogenesis
of ALI/ARDS following trauma. This project evaluates both
SNP-based haplotypes and functional SNPs in ALI/ARDS risk.
In addition, through the ARDSnet, he is currently conducting
an ancillary study evaluating the long-term cognitive and
neurological outcomes following ALI/ARDS.
Representative publications:
Christie JD, Robinson N, Ware L, Plotnick M, DeAndrade J, Lama V, Milstone
A, Orens J, Weinacker A, DeMissie E, Bellamy S, Kawut S,
for the Lung Transplant Outcomes Group. Association Of Protein
C And Type-1 Plasminogen Activator Inhibitor With Primary
Graft Dysfunction Am J Respir Crit Care Med 2007 Jan 1;175(1):69-74.
Christie JD*, Marzec J*, Reddy S, Jedlicka AE, Vuong H,
Lanken PN, Aplenc R, Cho HY, Kleeberger SR. Functional Polymorphisms
in the Transcription Factor NRF2 are Associated with Increased
Risk of Acute Lung Injury. FASEB Journal 2007 Jul;21(9):2237-46.
(* indicates equal contribution to the work)
Christie JD, Robinson N, Ware L, Plotnick M, DeAndrade
J, Lama V, Milstone A, Orens J, Weinacker A, DeMissie E,
Bellamy S, Kawut S, for the Lung Transplant Outcomes Group.
Association Of Protein C And Type-1 Plasminogen Activator
Inhibitor With Primary Graft Dysfunction Am J Respir Crit
Care Med 2006 00:000-000 (in press)
Christie JD, Kotloff RM , Ahya VN, Tino G, Pocchetino A,
Gaughan C, DeMissie E, Kimmel SE. The Effect of Primary
Graft Dysfunction on Survival Following Lung Transplantation.
Am J Respir Crit Care Med 2005 171(11):1312-1316.
Christie JD, Sager J, Kimmel SE, Ahya V, Gaughan C, Blumenthal
N, Kotloff RM. Impact of Primary Graft Failure on Outcomes
Following Lung Transplantation. Chest 2005, 127(1):161-5
Christie JD, VanRaemdonck D, de Perrot M, Barr M, Keshavjee
S, Arcasoy S, Orens J. Report of the ISHLT Working Group
on Primary Lung Graft Dysfunction. Part I: Introduction
and Methods. Journal of Heart and Lung Transplantation 2005
(10):1451-3
Christie JD, Carby M, Bag R, Corris P, Hertz M, Weill D.
Report of the ISHLT Working Group on Primary Lung Graft
Dysfunction. Part II: Definition - Consensus Statement of
the International Society for Heart and Lung Transplantation.
Journal of Heart and Lung Transplantation 2005 (10):1454-9
Christie JD, Kotloff RM , Pocchetino A, Arcasoy SM, Blumenthal
NP, Landis JR, Kimmel SE. Clinical Risk Factors For Development
Of Primary Graft Failure Following Lung Transplantation.
CHEST 2003; 124: 1232-1241.
Christie JD, Plotkin R, Taichman
D, Shull W, Hansen-Flaschen J, Shea JA, Hopkins RO. Formation
and Validation of a Telephone Battery to Assess Cognitive
Function in ARDS Survivors. Journal of Critical Care 21(2):125-132.
Christie JD, Marzec J, Reddy S, Jedlicka AE, Vuong H, Lanken
PN, Aplenc R, Cho HY, Kleeberger SR. Functional Polymorphisms
in the Transcription Factor NRF2 are Associated with Increased
Risk of Acute Lung Injury (Submitted)
Christie JD, Aplenc RA, Vachani A, Lanken PN, Foulkes A,
Gaughan C, Gallup R, Albelda SM, Landis JR, Rebbeck T. Genetic
Variation In The Catalase Gene And The Risk Of Acute Lung
Injury Following Major Trauma. (Submitted)
Christie JD, Aplenc R, DeAndrade J, Kawut S, Milstone A,
Weinacker A, Zhou L, Mazzotta J, DeMissie, Orens J. Donor
Glutathione S-Transferase Genotype is Associated with Primary
Graft Dysfunction Following Lung Transplantation. (Submitted)
Chapters and Editorials
Christie JD, Lanken PN: The Acute Respiratory Distress Syndrome.
In Fishman’s Pulmonary Diseases and Disorders. Grippi
M, Ed. McGraw-Hill Company, New York, 2006, in press.
Christie JD, Lanken PN: “Acute Respiratory Distress
Syndrome” in the ACP-PIER online program for the American
College of Physicians (http://pier.acponline.org/physicians/diseases/d349/d349.html)/
Christie JD: IL-10, age, and Acute Lung Injury genetics:
the action is in the interaction. European Respiratory Journal
2006; 27(4):669-70.
Christie JD, Lanken PN, Schmidt G: The Acute Respiratory
Distress Syndrome and Acute Hypoxemic Respiratory Failure.
In Principles and Practice of Critical Care, 3rd edition.
Hall J, Schmidt G, Eds. McGraw-Hill Company, 2005
Christie JD, Lanken PN, Schmidt G: The Acute Respiratory
Distress Syndrome and Acute Hypoxemic Respiratory Failure.
In Principles and Practice of Critical Care, 3rd edition.
Hall J, Schmidt G, Eds. McGraw Hill Company, 2005, (In Press)
Christie JD: Lung Allograft Ischemic Time: Crossing the
Threshold. Am J Respir Crit Care Med 2005; 171(7):673-4.
Christie JD: Genetic Epidemiology of Acute Lung Injury:
Choosing the Right Candidate Genes is the First Step. Critical
Care 2004; 8(6):411-3
Rubenfeld GR, Christie JD: The epidemiologist in the intensive
care unit. Intensive Care Med., Jan, 30(1):4-6, 2004.
Christie JD, Lanken PN: Withdrawal of Life Support and
Terminal Sedation in the Intensive Care Unit. In Palliative
and End of Life Pearls. Heffner JE, Byock I, Eds. Lippincott
Raven Publishing, 2002, p.198-201.
