Vera P. Krymskaya, PhD

Vera P. Krymskaya, PhD

Research Associate Professor of Medicine

University of Pennsylvania Medical Center
Pulmonary, Allergy & Critical Care Division
Translational Research Building
125 S. 31st Street
Philadelphia, PA 19104-3403

tel.: (215) 573-9861
fax.: (215) 573-4469
email: krymskay@mail.med.upenn.edu

Education:

PhD: Moscow State University, Russia
Postdoctoral Fellowship: University of Pennsylvania

Dr. Krymskaya's research interests are in the signal transduction mechanisms regulating cell growth, proliferation and migration. Her basic science studies are translated into the identifying therapeutic targets to treat rare lung cancer lymphangioleiomyomatosis (LAM), pulmonary arterial hypertension and asthma. Dr. Krymskaya discovered the function of tumor suppressor TSC2 as a negative regulator of S6K1, and S6K1 as a molecular target to treat LAM disease. This discovery was immediately transferred to the clinic, and the first clinical trail for LAM patients started at the Children’s Hospital Medical Center in Cincinnati, OH. For this achievement Dr. Krymskaya has honored by The Science Advancement Award from The LAM Foundation.

Representative publications:

Goncharova, E. A., Goncharov, D. A., and V. P. Krymskaya: Assay for in vitro monitoring of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cell migration. Nature Protocols 1(6): 2933-2939, Dec 2006.

Goncharova, E.A., Lim, P., Goncharov, D.A., Eszterhas, A., Panettieri, R.A., Jr. and Krymskaya, V.P.: Assay for in vitro monitoring of proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells. Nature Protocols 1(6): 2905-2908, Dec 2006.
Goncharova, EA and Krymskaya, VP: Pulmonary Lymphangioleiomyomatosis (LAM): Progress and Current Challenges Journal of Cellular Biochemistry. Wiley-Liss, Inc. Vol. Published On-line on May 31, 2007.

Krymskaya, VP: Smooth Muscle-Like Cells in Pulmonary Lymphangioleiomyomatosis (LAM). Proceedings of the American Thoracic Society Vol. In Press, 2007.

Vera P. Krymskaya: Targeting Phosphatidylinositol 3-Kinase in Airway Smooth Muscle: Rationale and Promise. BioDrugs. Adis International, Ltd, 21(2): 85-95, 2007.

revised 7/07

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