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Pulmonary, Allergy and Critical Care Division
836 West Gates Building
3400 Spruce Street
Philadelphia, PA 19104
tel.: 215-615-5416
fax: 215-614-0869
email: mark.mikkelsen@uphs.upenn.edu
• M.D.: University of Virginia
School of Medicine
• Residency: Hospital of the University
of Pennsylvania
• Fellowship: Hospital of the University
of Pennsylvania
• M.S.C.E.: University of Pennsylvania
Dr. Mikkelsen received his BA in Political Science from
Colgate University in 1996 and his MD from the University
of Virginia School of Medicine in 2002. After completing
his Internship and Residency in Internal Medicine at the
Hospital of the University of Pennsylvania, Dr. Mikkelsen
served as a post-doctoral fellow in the Division of Pulmonary,
Allergy, and Critical Care Medicine at the Hospital of the
University of Pennsylvania. During his fellowship, Dr. Mikkelsen
received his Master of Science in Clinical Epidemiology
under the mentorship of Jason D. Christie, MD, MSCE.
Dr. Mikkelsen joined the Section of Critical Care within
the Division of Pulmonary, Allergy, and Critical Care Medicine
as an Intensivist after completion of his fellowship. As
an educator, Dr. Mikkelsen is actively involved in the on-going
efforts to improve the critical care curriculum for the
Internal Medicine residency program and the Pulmonary and
Critical Care fellowship program.
His clinical interests include the management of sepsis
and acute lung injury in the acute care setting and the
sequelae of critical illness in survivors of critical illness.
Dr. Mikkelsen serves as an attending physician in the Medical
Intensive Care Unit and the Procedure and Resuscitation
Service at the Hospital of the University of Pennsylvania
and at the Long Term Acute Care Hospital at Penn at Rittenhouse.
His research interests focus on the care of patients with
sepsis and acute lung injury, aimed both at improving recognition
of patients at risk, as well as effectively translating this
knowledge into quality patient care at the bedside. Dr. Mikkelsen
is also passionate in his investigation to better understand
the frequency and determinants of neurocognitive and neuropsychiatric
impairment in survivors of critical illness.
Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs
BD, Shah CV, Bellamy SL, Christie JD. Serum lactate is associated
with mortality in severe sepsis independent of organ failure
and shock. In press at Crit Care Med
Mikkelsen ME, Shull WH, Biester RC, Taichman DB, Lynch S,
Demissie E, Hansen-Flaschen J, Christie JD. Cognitive, mood,
and quality of life impairments in a select population of
ARDS survivors. Respirology 2009; 14: 76-82
Mikkelsen ME, Woo YJ, Sager JS, Fuchs BD, Christie JD. Outcomes
using extracorporeal life support for adult respiratory
failure due to status asthmaticus. ASAIO 2009; 55(1): 47-52
Mikkelsen ME, Dedhiya P, Kalhan R, Gallop R, Lanken PN,
Fuchs BD. Potential reasons why physicians underuse lung
protective ventilation: a retrospective cohort study using
physician documentation. Resp Care 2008; 53(4): 455-461
Mikkelsen ME, Pugh M, Hansen-Flaschen J, Woo YJ, Sager
JS. Emergency extracorporeal life support for asphyxic status
asthmaticus. Resp Care 2007; 52(11): 1525-1529
Kalhan R, Mikkelsen ME, Dedhiya P, Christie J, Gaughan
C, Lanken PN, Finkel B, Gallop R, Fuchs BD. Under use of
lung protective ventilation: analysis of potential factors
to explain physician behavior. Crit Care Med 2006; 34: 300-306
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