Michael Sims, M.D.

Instructor of Medicine
Director of Clinical Research, Airways Biology Initiative

University of Pennsylvania Medical Center
Pulmonary, Allergy, and Critical Care Division
4th floor Andrew Mutch Building
Penn Presbyterian Medical Center
51 North 39th Street
Philadelphia, PA 19104
Outpatient clinic phone: (215) 662-3202
Administrative phone: (215) 662-8742
fax: (215) 243-4682

email: michael.sims@uphs.upenn.edu

Education:

M.D.: University of Pennsylvania School of Medicine

Residency: Hospital of the University of Pennsylvania

Fellowship: Hospital of the University of Pennsylvania

M.S.C.E. program: University of Pennsylvania

Dr. Sims is Director of Clinical Research for the Airways Biology Initiative, a comprehensive basic and clinical research enterprise devoted to understanding and curing diseases of the airways such as asthma and chronic obstructive pulmonary disease (COPD). He has received formal training in clinical research methods, having completed his Master’s degree in Clinical Epidemiology at the University of Pennsylvania. His individual research interest focuses on the role of surfactant protein D in modulating airway inflammation in COPD, and he is the principal investigator of an NIH (NHLBI) K23 award investigating that topic. In addition, Dr. Sims serves as a principal investigator or co-investigator on eight other studies evaluating biomarkers and/or novel therapies in COPD and asthma. Dr. Sims’s corresponding clinical interest is in the management of severe COPD and he has expertise in the evaluation of candidates for lung volume reduction surgery and experimental treatments such as intrabronchial valve placement for treatment of advanced emphysema.

Sims MW, Tal-Singer RM, Kierstein S, Musani AI, Beers MF, Panettieri RA, Haczku A. Chronic obstructive pulmonary disease and inhaled steroids alter surfacant protein D (SP-D) levels: a cross-sectional study. Respiratory Research 9(13), January 2008.

Amrani Y, Tliba O, Krymskaya VP, Sims MW, Panettieri RA. Airway smooth muscle. Asthma and COPD:  Basic Mechanisms and Clinical Management, 2nd ed. Barnes PJ, Drazen JM, Rennard S, Thomson NC. (eds.). Elsevier/Academic Press, San Diego, CA, 2008.

Sims MW, Margolis DJ, Localio AR, Panettieri RA, Kawut SM, Christie JD. Impact of pulmonary artery pressure on exercise function in severe chronic obstructive pulmonary disease. Chest, in press.

Panettieri RA, MacIntyre N, Sims MW, Kerwin E, Fogarty C, Noonan M, Claus R, Andrews WT. Comparison of efficacy and safety of arformoterol 15 µg twice daily with arformoterol 30 µg once daily in subjects with COPD: a randomized, modified blind, multicenter, single dose, two way crossover study. Clinical Therapeutics, in press.

Sims MW. Acute respiratory failure due to chronic obstructive pulmonary disease. The Intensive Care Unit Manual, 2nd ed. Lanken PN, Hanson CW, Manaker S (eds.).  Elsevier, in press.