Dr. Panettieri directs the Airways Biology Initiative at
the University of Pennsylvania. His interests are in the
cellular and molecular mechanisms that regulate airway smooth
muscle cell growth and the immunobiology of airway smooth
muscle. Consequences of increases in airway smooth muscle
growth promote the development of irreversible airflow obstruction
and airway remodeling seen in subjects with chronic severe
asthma. Dr. Panettieri's lab also focuses on cytosolic signaling
pathways that mediate gene expression and alter myocyte
function.
In parallel with his basic science interests, Dr. Panettieri
currently directs the comprehensive clinical program for
the care of patients with asthma and is actively involved
in clinical investigations focused on the management of
asthma and COPD.
In addition to his research and clinical interests, Dr.
Panettieri served as chairperson of the Lung Cellular, Molecular,
and Immunobiology Study Section of NIH and is a member of
the American Society for Clinical Investigation and Association
of American Physicians.
Panettieri Jr RA: In the Clinic. Asthma. Ann Intern Med
146:ITC6-1-ITC6-16, 2007.
Edwards MR, Haas J, Panettieri Jr RA, Johnson M, Johnston
SL: Corticosteroids and ß2 agonists differentially
regulate rhinovirus induced IL-6 via distinct cis-acting
elements. J Biol Chem 282:15366-15375, 2007.
Tirumurugaan KG, Jude JA, Kang BN, Panettieri Jr RA, Walseth
TF, Kannan MS: TNF-a induced CD38 expression in human airway
smooth muscle cells: role of MAP kinases and transcription
factors NF-?B and AP-1. Am J Physiol-Lung Cell Mol Physiol
292:L1385-L1395, 2007.
Goncharova EA, Lim P, Goncharov DA, Eszterhas A, Panettieri
Jr RA, Krymskaya VP: Assays for in vitro monitoring of proliferation
of human airway smooth muscle (ASM) and human pulmonary
arterial vascular smooth muscle (VSM) cells. Nature Protocols
1:2905-2908, 2006.
Kang BN, Tirumurugaan KG, Deshpande DA, Amrani Y, Panettieri
Jr RA, Walseth TF, Kannan MS: Transcriptional regulation
of CD38 expression by tumor necrosis factor-a in human airway
smooth muscle cells: role of NF-?B and sensitivity to glucocorticoids.
FASEB J 20:1000-1002, 2006.
Panettieri Jr RA: Cellular and molecular mechanisms regulating
airway smooth muscle physiology and pharmacology. J Organ
Dysfunc 2:37-47, 2006.
Lazaar AL, Panettieri Jr RA: Airway smooth muscle as a regulator
of immune responses and bronchomotor tone. Clinics in Chest
Medicine 27:53-69, 2006.
Krymskaya VP, Goncharova EA, Ammit AJ, Lim PN, Goncharov
DA, Eszterhas A, Panettieri Jr RA: Src is necessary and
sufficient for human airway smooth muscle cell proliferation
and migration. FASEB J 19:428-430, 2005.
Lazaar AL, Panettieri Jr RA: Airway smooth muscle: A modulator
of airway remodeling in asthma. J Allergy Clin Immunol 116:488-495,
2005.
