Department of Neurology

Department Home >

  • Base >
  • You are here
Department of Neurology

Center for Functional Neuroimaging

Over the past decade, there has been an exponential growth in the utilization of neuroimaging in almost every aspect basic and clinical neuroscience. In particular, magnetic resonance neuroimaging methods permit noninvasive measurements brain structure and function with excellent spatial, temporal, and functional resolution.

While there are numerous applications of imaging methods to animal models, imaging methods are typically the sole means of directly assessing human brain function and provide an important link between behavior and brain that complements observations made in individuals with brain lesions, providing converging evidence of functional localization and organization.

The University of Pennsylvania has a long tradition of innovation and excellence in human neuroimaging, starting with the first cerebral blood flow measurements in humans by Seymour Kety in the 1940’s.

While structural neuroimaging in human patients has traditionally been under the auspices of Departments of Radiology, functional neuroimaging is much more multidisciplinary, with Departments of Neurology at the forefront of applications. The first human fluorodeoxyglucose (FDG) images of brain metabolism were carried out in the 1970’s by Martin Reivich at Penn’s Department of Neurology, in collaboration with Abass Alavi and others in the Department of Radiology.

The Center for Functional Neuroimaging (CfN), established in 2003 to provide infrastructure support for basic and clinical neuroimaging at Penn, continues the tradition of multidisciplinary research in neuroimaging. Under the leadership of Dr. John A. Detre, Associate Professor of Neurology and Radiology, the CfN draws upon multidisciplinary expertise and resources to advance the general interests of the brain imaging community at the University of Pennsylvania through targeted methods development, symposia and colloquia, handling of regulatory issues, and fund-raising efforts.

The CfN is formally a Type 1 center in the Department of Radiology, but currently receives intramural support from the Departments of Radiology, Psychiatry, and Neurology, the School of Medicine, the Office of the Provost, and extramural support from the NIH in the form of a P30 Center Core grant (J.A. Detre, P.I.).

Top ^