Penn Medicine Neuroscience Center

About the Center

Funding Opportunities and Grants

A major goal of the Penn Medicine Neuroscience Center (PMNC) is to promote integrated basic, translational and clinical research efforts – with the ultimate goal of improving patient care.

FY15 Pilot Innovative Research Projects - Call for Proposals

The Penn Medicine Neuroscience Center (PMNC) invites proposals for the support of pilot research projects in the broad category of the neurosciences.  The focus of the pilots this year is on “Interdisciplinary Research”.  Applicants are encouraged to include more than one discipline and illustrate a multi-faceted approach to a scientific problem.

Click here to view the Call for Proposals for Innovative Pilot Research Projects.

The purpose of this program is to assist Penn faculty in generating preliminary data that may serve as the basis for seeking longer-term funding from federal, foundation or corporate sources.  A major goal of the PMNC is to promote the development of creative ideas and approaches in neuroscience, and so we invite proposals that seek to test an innovative hypothesis or develop a new tool via interdisciplinary research.  Applications with more than one investigator must indicate how the different expertise of the co-investigators will contribute to the overall goals of the project.

Previously Awarded Projects

FY14 Pilot Innovative Research Projects

The PMNC funded 9 collaborative research projects for FY14. The innovative research project titles are listed below:

  • Transparent Graphene Electrodes for Simultaneous Electrophysiology and Neural Recording with Single-cell Resolution
  • Optogenetic Inhibition of GPCR Signaling
  • A new tool for real time monitoring of the unfolded protein response in behaving flies
  • Multicellular Chloride Imaging and Network Dynamics: Two-Photon Excitation Fluorescence Lifetime Imaging (2P-FLIM) Approach
  • The role of the DNER in the function of the adult cerebellum
  • Neuromodulation of Brain Circuits Using Transplantable Micro-Tissue Engineered Neural Networks
  • Role of ERRγ in Parkinson’s disease
  • Amylin Signaling in the Ventral Tegmental Area Controls Food Intake
  • Cholinergic Modulation of Anxiety-related Brain Circuits

FY13 Pilot Innovative Research Projects

The PMNC funded 8 collaborative research projects for FY13. The innovative research project titles are listed below:

  • Labeling Newly Phosphorylated Proteins in Response to Signal Pathway Activation
  • Defining the role of TRIM proteins in protection against neurodegeneration
  • Imaging learning dependent neuronal activity patterns in behaving animals
  • Epigenetic Control of Experience-dependent Neural Plasticity
  • Prefrontal computations for reward-biased perceptual decisions
  • Using RNA-Seq To Relate Odorant Receptor, Axonal Guidance Receptor, And Transcription Factor Expression Patterns In Single Isolated Olfactory Sensory Neurons
  • Functional Connectivity and Persistent Dysfunction in Mild Traumatic Brain Injury
  • Optical Measurement of Absolute Membrane Potentials

FY12 Pilot Collaborative Research Projects

The PMNC funded 10 collaborative research projects in the total amount of $500,000 for FY12. The investigators collaborating on the 10 funded projects represent 18 different departments and 5 Penn schools. The currently funded collaborative research project titles are below:

  • Development of a novel MRI biomarker to assess brain white matter
    integrity in traumatic brain injury
  • The ReCoUPS Pilot: Recovering Concussion Update on Progression of
  • The role of cortico-cortical connections of the mammalian sensory cortex
    in information processing
  • Novel FLIM based approach to study HSV-1 entry into neurons
  • Model Investigation of mTOR Pathway Modulation in Autism and Epilepsy
  • Common and Divergent Mechanisms of Anhedonia Across Psychiatric
  • Light-induced gene activation in C. elegans
  • Elucidating the link between stress and tauopathies such as Alzheimer’s
  • Watching the single neuron in action: monitoring metabolic responses at
    a single cell level
  • Investigation of Tau-Interacting Aminothienopyridazines

Click here to learn more about previously awarded projects.