Resident Physician, PGY-2

Department of Neurosurgery, Silverstein 3
The Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
(215) 662-3487
Han-ChiaoIsaac.Chen@uphs.upenn.edu

Biographical Sketch

Dr. Chen is currently a PGY-2 at the Hospital of the University of Pennsylvania.

Education

• 8/1998-6/2002 AB Harvard University
• 8/2002-5/2007 MD University of Pennsylvania

Awards, Honors, and Membership in Honorary Societies

• 2007 Alpha Omega Alpha
• 2006 Emily and Francis Botelho Prize for Excellence in Basic Science
• 2006 Dr. Freddy Stark Anatomy Teaching Assistant Award
• 2005-06 Howard Hughes Medical Institute Research Training Fellowship
• 2002-07 Gamble Scholar
• 2002 Phi Beta Kappa
• 1998 USA Today All-USA High School Academic First Team
• 1997 Pennsylvania Governor's School for the Sciences
• 1997 Young Artists Piano Program, Boston University Tanglewood Institute

Original Papers

Magge SN, Chen HI, Stiefel MF, Ernst L, Cahill AM, Hurst R, Storm PB. Rapid progression and multiple ruptures of cerebral aneurysms in an 18-month-old child with Takayasu Arteritis.  Journal of Neurosurgery: Pediatrics 1(1):83-8, 2008.

Dahl J, Chen HI, George M, Benjamin TL. Polyoma small T antigen controls viral chromatin modifications through effects on kinetics of virus growth and cell cycle progression.  Journal of Virology:81(18):10064-10071, 2007.

Royo NC, LeBold D, Magge SN, Chen HI, Hauspurg A, Cohen AS, Watson DJ. Neurotrophic-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function.  Neuroscience:148(2):359-370, 2007.

Magge SN, Chen HI, Heuer G, Carracsco LR, Storm PB. Fracture of the mandible into the middle cranial fossa.  Case report.  Journal of Neurosurgery: Pediatrics 107(1):75-78, 2007.

Chen HI, Heuer GG, Zaghloul K, Simon SL, Weigele JB, Grady MS. Lumbar vertebral hemangioma presenting with the acute onset of neurological symptoms.  Case report.  Journal of Neurosurgery: Spine 7(1):80-85, 2007.

Chen HI, Bakshi A, Royo NC, Magge SN, Watson DJ. Neural stem cells as biological minipumps: A faster route to cell therapy for the CNS?  Current Stem Cell Research and Therapy 2(1):13-22, 2007.

Chen HI, Burnett MG, Huse JT, Lustig RA, Bagley LJ, Zager EL. Recurrent late cerebral necrosis with aggressive characteristics after radiosurgical treatment of an arteriovenous malformation.  Journal of Neurosurgery 105(3):455-460, 2006.

Magge SN, Chen HI, Zager EL. Dystrophic calcification and infraclavicular brachial plexopathy: Case report.  Neurosurgery 58(6):E216, 2006.

Chen HI, Malhotra NR, Oddo M, Heuer GG, Levine JM, LeRoux PD. Barbiturate infusion for intractable intracranial hypertension and its effects on brain oxygenation.  Neurosurgery (accepted).

Oddo M, Milby A, Chen HI, Frangos S, MacMurtrie E, Maloney-Wilensky E, Stiefel MF, Kofke WA, Levine JM, LeRoux PD. Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage.  Stroke (accepted).

Oddo M, Frangos S, Milby A, Chen HI, Maloney-Wilensky E, MacMurtrie E, Stiefel MF, Kofke WA, LeRoux PD, Levine JM. Treatment of refractory fever with surface cooling attenuates cerebral metabolic distress after severe brain injury.  Stroke (under revision).

Magge SN, Royo NC, Chen HI, Yu L, Snyder EY, O’Rourke DM, Watson DJ. Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells towards glial tumors.  Journal of Neuroscience Research (under revision).

Magge SN, Chen HI, Cen L, Chen Z, Elliott JP, Winn HR, LeRoux PD. Younger age is associated with an increased risk of angiographic and symptomatic vasospasm after subarachnoid hemorrhage.  Stroke (submitted).

Evans SM, Jenkins K, Jenkins WT, Judy KD, Diling T, Hwang W, Nelson P, Chen HI, Koch CJ. Quantitative analysis of cellular proliferation and blood vessel function as related to hypoxia in human gliomas.  Radiotherapy and Oncology (submitted).

Abstracts

Oddo M, Frangos S, Milby A, Chen HI, Maloney-Wilensky E, Macmurtrie E, Kofke A, LeRoux PD, Levine JM.  Temperature control and cerebral tissue metabolism in patients with severe brain injury: a preliminary study.  European Society of Intensive Care Medicine, 2008.

Chen HI, Oddo M, Milby A, Frangos S, MacMurtrie E, Maloney-Wilensky E, Stiefel M, Kofke WA, Levine JM, LeRoux PD. Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage.  Congress of Neurological Surgeons, 2008. [Oral presentation]

Evans SM, Jenkins K, Chen HI, Jenkins T, Judy KD, Wang W, Lustig RA, Grady MS, Hahn SM, Koch CJ. The pO2 of cycling cells is an independent predictor of recurrence and survival in human glioblastomas.  American Society of Therapeutic Radiology and Oncology, 2008.  [Oral presentation]

Urban C, Chen HI, Hojat A, Church W, Lee JYK. Measurement of pain severity using validated outcome scales in typical versus atypical trigeminal neuralgia.  Congress of Neurological Surgeons, 2008.

Chen HI, Haydon PG, Watson DJ. Differential pathotropic migration of endogenous neural stem cells towards F98 vs 9L tumors.  Society for Neuroscience, 2007.  [Oral presentation]

Milby A, Chen HI, Stiefel MF, Maloney-Wilensky E, Zager EL, Levine J, Kofke WA, LeRoux PD. Hemoglobin and cerebral metabolism after subarachnoid hemorrhage.  Congress of Neurological Surgeons, 2007.

Chen HI, Stiefel MF, Maloney-Wilensky E, Levine J, Kofke WA, LeRoux PD. Cerebral lactate:pyruvate ratio and brain tissue oxygen in subarachnoid hemorrhage.  International Symposium on Intracranial Pressure and Brain Monitoring, 2007.

Stiefel MF, Chen HI, Heuer GG, Udoetuk J, LeRoux PD, Zager, EL, Wolf, R. The relationship between xenon CT cerebral blood flow and brain tissue oxygen in poor grade subarachnoid hemorrhage patients.  International Symposium on Intracranial Pressure and Brain Monitoring, 2007.

Chen HI, Royo NC, Magge SN, Haydon PG, Watson DJ. Endogenous neural stem cell migration toward gliomas.  Society for Neuroscience, 2006.

Chen HI, Malhotra NR, Levine J, LeRoux PD: Effect of barbiturate infusion on cerebral oxygenation.   Congress of Neurological Surgeons, 2006.

Magge SN, Chen HI, Choe H, Ichord R, Storm PB: Symptomatic vasospasm in the pediatric population after aneurysmal subarachnoid hemorrhage.  AANS/CNS Joint Section on Pediatric Neurological Surgery, 2006.