Department of Neurosurgery

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Penn Neurosurgery

Current Residents - Gregory Heuer, MD, PhD

Resident Physician, PGY-6

Gregory Heuer, MD

Department of Neurosurgery, Silverstein 3
The Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
(215) 662-3487
gregory.heuer@uphs.upenn.edu

 
Biographical Sketch

Dr. Heuer graduated summa cum laude from the University of Minnesota in 1995 with a degree in Genetics and Cell Biology. He received his medical degree from the University of Pennsylvania in 2003. Dr. Heuer received a Ph.D. in Cell and Molecular Biology in 2001 after he successfully defended his thesis dissertation entitled “Studies on Neural Stem Cells and Neuropathology in an Inherited Lysosomal Storage Disease Animal Model”. He is currently serving as a PGY-6 in the Department of Neurosurgery at the Hospital of the University of Pennsylvania. Dr. Heuer’s research interests include the molecular mechanisms underlying genetic forms of epilepsy, surgery for movement disorders and epilepsy, fetal neurosurgery, and pediatric neuro-oncology.

Publications

Heuer, G.G., Zaghloul, K.A., Roberts, R, Stiefel, M.F., Storm, P.B. Successful Microsurgical Extraction of a Migrated Coil After Failed Endovascular Closure of a Blalock-Taussig Shunt. Journal of Neurosurgery: Pediatrics. Journal of Neurosurgery 106(2): 136-138, 2007.

Stiefel, M.F., Heuer, G.G., Abrahams, J.M., Bloom, S., Maloney-Wilensky, E., LeRoux, P.D. The Effect of Nimodipine on Cerebral Oxygenation in Poor Grade Subarachnoid Hemorrhage Patients. Journal of Neurosurgery, 101(4):594-599, 2004.

Heuer, G.G., Smith M.J., Elliott J.P., Winn H.R., Le Roux P.D. The Relationship between Intracranial Pressure and Other Clinical Variables in Patients with Aneurysmal Subarachnoid Hemorrhage. Journal of Neurosurgery, 101(3): 408-416, 2004.

Stiefel M.F., Heuer G.G., Smith M.J., Bloom S., Maloney-Wilensky E., Gracias V.H., Grady, M.S., Le Roux P.D. Cerebral Oxygenation Following Decompressive Hemicraniectomy for the Treatment of Refractory Intracranial Hypertension. Journal of Neurosurgery 101(2):241-247, 2004.

Heuer, G.G., Passini, M.A., Jiang, K., Parente, M.K., Lee, V.M.-Y., Trojanowski, J.Q., and Wolfe, J.H. Selective Neurodegeneration in the Murine Mucopolysaccharidosis VII Brain is Progressive and Reversible. Annals of Neurology, 17:167-178, 2003.

Passini, M.A., Lee, E.B., Heuer, G.G., and Wolfe, J.H. Distribution of a Lysosomal Enzyme in the Adult Brain by Axonal Transport and by Cells of the Rostral Migratory Stream. Journal of Neuroscience , 22: 6437-6446, 2002.

Prasad Alur, R.K., Foley, B., Parente, M.K., Tobin, D.K., Heuer, G.G, Avadhani, A.N., Pongubala, J., and Wolfe, J.H. Modification of Multiple Transcriptional Regulatory Elements in a Moloney Murine Leukemia Virus Gene Transfer Vector Circumvents Silencing in Fibroblast Grafts and Increases Levels of Expression of the Transferred Enzyme. Gene Therapy, 9: 1146-1154, 2002.

Heuer, G.G., Skorupa, A., Prasad Alur, R.K., Jiang, K., and Wolfe, J.H. Accumulation of Abnormal Amounts of Glycosaminoglycans in Murine Mucopolysaccharidosis Type VII Neural Progenitor Cells Does Not Alter the Growth Rate or Efficiency of Differentiation into Neurons. Molecular and Cellular Neuroscience. 17: 167-178, 2001.

Heuer, G.G., Jackson, E.M., Magge, S.N., Storm, P.B. Surgical Management of Pediatric Brain Tumors. Expert Reviews in Neurotherapeutics. In Press.

Puffenberger, E.G., Strauss, K.A., Ramsey, K.E., Craig, D.W., Stephan, D.A., Robinson, D.L., Hendrickson, C.L., Gottlieb, S., Ramsay, D.A., Siu, V.M., Heuer, G.G., Crino, P.B., and Morton, D.H. Polyhydramnios, megalencephaly, and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5 . Brain, in press.

Magge, S.N., Chen, H.I., Heuer, G.G., Carrasco, L.R., Storm, P.B. Dislocation of the Mandible into the Middle Cranial Fossa. Journal of Neurosurgey: Pediatrics. In press.

Chen, H.I., Heuer, G.G.,. Zaghloul, K.A., Simon, S.C., Weigele, J.B, Grady, M.S. Lumbar Vertebral Hemangioma Presenting with the Acute Onset of Neurological Symptoms. Journal of Neurosurgey : Spine. In press.

Heuer, G.G., Zaghloul, K.A., Jaggi, J.L., Baltuch, G.H. Use of an Integrated Platform System in the Placement of Deep Brain Stimulators. Operative Neurosurgery. In Press.

Presentations / Abstracts

Heuer, G.G., Stiefel, M.F., Basil, A.K, Weigele, J.B., Sutton, L., Hurst, R.W., Storm, P.B. Endovascular and Surgical Treatment of Ruptured Cerebral Aneurysms in Pediatric Patients. Pennsylvania Neurosurgical Society Annual Meeting, 2007.

Heuer, G.G., Idoko, K.E., Jackson, E., Zaghloul, K.A., Stiefel, M.F., Baltuch, G.H., Schuster, J. Use of a Catheter System for Drainage of Chronic Subdural Hematomas. Pennsylvania Neurosurgical Society Annual Meeting, 2007.

Heuer, G.G., Jeyamohan, S., Malhotra, N., Zaghloul, K.A., Magge, S.N., Storm, P.B. Use of Expandable Cages in Pediatric Lumbar Burst Fractures. Pennsylvania Neurosurgical Society Annual Meeting, 2007.

Stiefel, M.F., Udoetuk, J.D., Bauman, J., Heuer, G.G., Levine, J.M., Kofke, A., Collins, R., Zager, E.L., Grady, M.S., LeRoux, P.D., Weigele, J.B., Hurst, R.W. Endovascular Treatment of Cerebral Vasospasm: a Comparison of the Effects of Intra-arterial Nicardipine and Intra-arterial Papaverine on Cerebral Circulation Time. Congress of Neurological Surgeons Annual Meeting, 2007.

Heuer, G.G., Idoko, K.E., Jackson, E., Zaghloul, K.A., Stiefel, M.F., Baltuch, G.H., Schuster, J. Use of a Catheter System for Drainage of Chronic Subdural Hematomas. Congress of Neurological Surgeons Annual Meeting, 2007.

Heuer, G.G., Jeyamohan, S., Malhotra, N., Zaghloul, K.A., Magge, S.N., Storm, P.B. Use of Expandable Cages in Pediatric Lumbar Burst Fractures. Congress of Neurological Surgeons Annual Meeting, 2007.

Heuer, G.G., Stiefel, M.F., Al-Okaili, R., Bagley, L., Weigle, J.B., Sutton, L.N., Hurst, R.W., Storm, P.B. Multimodality Treatment of Pediatric Cerebral Aneurysms. AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, 2006.

Heuer, G.G., Zaghloul, K.A., Roberts, R, Stiefel, M.F., Storm, P.B. Successful Microsurgical Extraction of a Migrated Coil After Failed Endovascular Closure of a Blalock-Taussig Shunt. AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, 2006.

Bauman, J.A., Heuer, G.G., Stiefel, M.F., Jaggi, J.L., Baltuch, G.B. Safety of Preoperative Subcutaneous Heparin Therapy in Deep Brain Stimulation Surgery. Congress of Neurological Surgeons Annual Meeting 2006.

Heuer, G.G., Stiefel, M.F., Kofke, A., Wolf, R., Maloney-Wilensky, E., Zager, E.L., LeRoux, P.D. Xenon Enhanced CT Scan is Safe in Neurocritical Care Patients. Congress of Neurological Surgeons Annual Meeting 2006.

Udoetuk, J.D., Michael F. Stiefel, M.F., Ramakrishna, R., Spiotta, A.M., Heuer, G.G., Bloom, S., Maloney-Wilensky, E., LeRoux, P.D. Hypervolemia does not Always Ensure Adequate Cerebral Oxygenation after Aneurysmal Subarachnoid Hemorrhage. American Association of Neurological Surgeons, 2006.

Stiefel, M.F., Spiotta, A.M., Ramakrishna, R., Heuer, G.G., Udoetuk, J.D., Maloney-Wilensky, E., Zager, E.L., M. Grady, M.S., LeRoux, P.D. Cerebral Perfusion Pressure to Maintain Cerebral Oxygen varies in TBI and SAH Patients. American Association of Neurological Surgeons, 2006.

Stiefel, M.F., Spiotta, A.M., Heuer, G.G., Udoetuk, J.D., Maloney-Wilensky, E., Grady, M.S., LeRoux, P.D. Medical Management to Maintain Cerebral Oxygenation in Patients with Traumatic Brain Injury. American Association of Neurological Surgeons, 2006.

Stiefel, M.F., Heuer, G.G., Garuffe, A., Bloom, S., Maloney-Wilensky, E., Grady, M.S., Gracias, V.H., LeRoux, P.D. Improved outcome with Brain Tissue Guided Management following TBI. Neurocritical Care Society Annual Meeting, 2005.

Spiotta, A.M., Stiefel, M.F., Heuer, G.G., Bloom, S., Maloney-Wilensky, E., Grady, M.S., LeRoux, P.D. Hyperthermia and Hyperglycemia Following Traumatic Brain Injury Do Not Involve Reduced Brain Oxygen. Neurocritical Care Society Annual Meeting, 2005.

Stiefel M., Guillamondegui O.D., Heuer G.G., Garuffe A.M., Bloom S., Maloney-Wilensky E., Grady M.S., Gracias V.H., Le Roux P.D., M.D. Conventional NeuroCritical Care Monitoring Fails to Ensure Cerebral Oxygenation. Congress of Neurological Surgeons Annual Meeting 2004

Stiefel, M.F., Heuer, G.G., Abrahams, J.M., Bloom, S., Maloney-Wilensky, E., LeRoux, P.D. The Effect of Nimodipine of Cerebral Oxygenation in Poor Grade Subarachnoid Hemorrhage Patients. Congress of Neurological Surgeons, 2004.

Stiefel, M.F., Heuer, G.G., Garuffe, A., Bloom, S., Maloney-Wilensky, E., Grady, M.S., Gracias, V.H., LeRoux, P.D. Brain Tissue Oxygen Directed Management Reduces Mortality in Patients with Severe Traumatic Brain Injury. Congress of Neurological Surgeons Annual Meeting 2004.

Stiefel, M.F, Gracias, V.F., Goldberg, A., Garuffe, A.M., Heuer G.G., Guillamondegui, O., Bloom, S., Maloney-Wilensky, E., Grady, M.S., LeRoux, P.D. Brain Tissue Oxygen Management Reduces Mortality in Traumatic Brain Injury. Pennsylvania Neurosurgical Society Annual Meeting, 2004.

Stiefel, M.F., Heuer G.G., Garuffe, A., Bloom, S., Maloney-Wilensky, E., Grady, M.S., Gracias, V.H., LeRoux, P.D. Conventional NeuroCritical Care Monitoring Fails to Ensure Adequate Cerebral Oxygenation in Patients with Severe Multi-system Trauma and Traumatic Brain Injury, Neurocritical Care Society Annual Meeting, 2004.

Stiefel M., Boockvar J., Heuer G.G., Smith M.J., Bloom S., Bagley L., Hurst R., Grady M.S., Le Roux P.D. The Effect of Cerebral Angiography on Brain Oxygen, Brain Temperature, and ICP in Comatose Subarachnoid Hemorrhage Patients. Congress of Neurological Surgeons Annual Meeting 2003.

Heuer G.G., Stiefel M., Danish S., M.D., Maloney-Wilensky E., Dolinskas C., Le Roux P.D. The dural substitute, Duragen is a safe and effective dural substitute for posterior fossa procedures. Congress of Neurological Surgeons Annual Meeting 2003.

Stiefel M.F., Heuer G.G., Boockvar J., Bloom S., Smith M.J., Schuster J., Grady M.S., Le Roux P.D. The synthetic dural substitute, Duragen, provides an effective dural barrier following Decompressive Hemicraniectomy. Congress of Neurological Surgeons Annual Meeting 2003.

Stiefel M.F., Heuer G.G., Smith M., Smith M.S., Bloom S., Maloney-Wilensky E., Gracias V., Pryor J., Grady M.S., LeRoux. P.D. Brain Oxygen Monitoring for Severe Brain Injury: An Analysis of 52 Patients. American Association of Neurological Surgeons, 2003.

Stiefel M.F., Heuer G.G., Smith M., Bloom S., Maloney-Wilensky E., Grady M.S., Le Roux P.D. Improved Cerebral Oxygenation Following Decompressive Hemicraniectomy in Patients with Refractory Intracranial Hypertension. American Association of Neurological Surgeons, 2003

Heuer G.G., Stiefel M.F., Maloney-Wilensky E., Danish S., Dolinskas C., and Le Roux P.D. DuraGen is an effective dural substitute: clinical experience with 100 patients. American Association of Neurological Surgeons, 2003

Heuer, G.G., LeRoux, P.D., Elliott, J.P., and Winn, H.R. Intracranial Pressure after Aneurysmal Subarachnoid Hemorrhage. Congress of Neurological Surgeons Annual Meeting, 2002.

Heuer, G.G., Stiefel, M., Smith, D., and Zager, E. Carotid Endarterectomy Under Regional Anesthesia: Patient Characteristics, Patient Selection, and Postoperative Clinical Outcomes. Congress of Neurological Surgeons Annual Meeting, 2002.

Passini, M.A., Lee, E.B., Heuer, G.G., Polesky, A.C., and Wolfe, J.H. Delivery of  -Glucuronidase in the Adult Mouse Brain by Axonal Transport Results in the Reversal of Storage Lesions in Regions Distal to the Transduction Site. American Society of Gene Therapy Annual Meeting, 2002.

Heuer, G.G., Prasad, A.R.K., Jiang, K., Passini, M.A., Skorupa, A., and Wolfe, J.H. MPS VII Neural Progenitor Cells Display Disease Specific Phenotypes in Culture and Can Serve as Enzyme Delivery Vehicles in the CNS. American Society of Gene Therapy Annual Meeting, 2000.

Jiang, K., Heuer, G.G., Watson, D., and Wolfe, J.H. Construction And Characterization Of A Fusion Protein Of Tetanus Toxin C Fragment And -Glucuronidase For Enzyme Delivery To Neurons. American Society of Gene Therapy Annua Meeting, 2000.

Passini, M.A., Jones, C.M., Heuer, G.G., and Wolfe, J.H. The Direct Administration of Adeno-Associated Virus into the Murine Brain Yields High Levels of -Glucuronidase Expression from a Housekeeping Promoter. Society for Neuroscience Annual Meeting, 1999.

Wolfe, J.H, Heuer, G.G., and Prasad Alur, R.K. Gene Therapy Using Neural Progenitor Cells in Lysosomal Storage Diseases. Proceedings of the International Workshop on Neuronal Precursor Cells and Application for Treatment of Inborn Errors of Metabolism with CNS Involvement, National Center of Neurology and Psychiatry, International Medical Center of Japan, February 1999.

Heuer, G.G., Prasad, A.R.K., Skorupa, A., Jiang, K., Watson, D., and Wolfe, J.H. Use of Neural Progenitor Cells to Study Neurodegenerative Disease Models and Gene Transfer Strategies in vitro. American Society of Gene Therapy Annual Meeting, 1999.

Prasad Alur , R.K., Heuer, G.G., and Wolfe, J.H. Decreasing the Pathology and Lysosomal Storage in the MPS VII Mouse Brain Through the Engraftment of Genetically Modified Cells. American Society of Gene Therapy Annual Meeting, 1999.

Heuer, G.G., Prasad, A.R.K., Skorupa, A., Flax, J.D., Snyder, E.Y., and Wolfe, J.H. Generation and Manipulation of MPS VII Mutant Neural Progenitor Cells for Use in CNS Gene Therapy. American Society of Gene Therapy Annual Meeting, 1998.

Heuer, G.G. and Noland, W. The Synthesis Of Tetrahydrocarbozoles As Leads To Potential Anti-HIV Compounds. American Chemical Society's Undergraduate Research Symposium, 1994.

Book Chapters

Heuer, G.G., Reiter, G.T., Stiefel, M.F., and Judy, K.D. Neurosurgery. In: The Surgical Review (second edition), Atluri, P., Karakousis, G.C., Porrett, P.M., and Kaiser, L.R.,(eds), Lippincott, Williams and Wilkins, 2006.

Heuer, G.G., Stiefel, M.F., and LeRoux, P.D. Trauma Flap/Hemicraniectomy. In: Fundamentals of Operative Techniques in Neurosurgery: Second Edition. Connolly, E.S., McKhann, G.M. II, Huang, J., Choudhri, T.F.(eds), Thieme, in press.

Heuer, G.G., Jaggi, J.L., Baltuch, G.H., Lee, J.Y.K. Frameless Stereotaxy for Placement of Deep Brain Stimulators. In: Functional Neurosurgery: First Edition. Baltuch, G.H. (eds), Thieme, in press.

Heuer, G.G., Bauman, J., Storm, P.B, Baltuch, G.H. Invasive EEG Studies: PEG, Strip, and Grid Implantation. In: Operative Techniques in Epilepsy Surgery: First Edition. Baltuch, G.H. Vellemure, J.G. (eds), Thieme, in press.

Heuer, G.G., Storm, P.B. Anatomic Hemispherectomy. In: Operative Techniques in Epilepsy Surgery: First Edition. Baltuch, G.H. Vellemure, J.G. (eds), Thieme, in press.

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