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APRIL 20, 2009
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Cdx2-deficient intestine resembles the esophagus

Normal esophagus (left panel), which is stained in brown for cytokeratin 13 (K13), a marker for esophageal epithelium. In the control intestine in the middle panel (CT ileum), no cytokeratin 13 is present. However, in the Cdx2 mutant intestine in the right panel (labeled MT ileum) cytokeratin is clearly visible in brown, indicating the transformation of the intestine into esophagus.

Credit: Nan Gao, PhD et al., Developmental Cell

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Normal esophagus (left panel), which is stained in brown for cytokeratin 13 (K13), a marker for esophageal epithelium. In the control intestine in the middle panel (CT ileum), no cytokeratin 13 is present. However, in the Cdx2 mutant intestine in the right panel (labeled MT ileum) cytokeratin is clearly visible in brown, indicating the transformation of the intestine into esophagus.
 


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