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Structure of a Hypoxia Inducible Factor-1a (HIF-1a) peptide bound to the von Hippel Lindau (VHL) protein. Hydroxylproline-564 (Hyp-564, highlighted in yellow) of HIF-1a occupies a Hyp-binding pocket of VHL.

Credit: Min et al., 2002, Science 296, 1886

Structure of a Hypoxia Inducible Factor-1a (HIF-1a) peptide bound to the von Hippel Lindau (VHL) protein. Hydroxylproline-564 (Hyp-564, highlighted in yellow) of HIF-1a occupies a Hyp-binding pocket of VHL. (Min et al., 2002, Science 296, 1886).
 


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