Canine retina two years post injection. Retinal photograph taken more than two years after subretinal injection of AAV2-hRPE65v2 in the second eye of a dog model of Leber's congenital amaurosis due to RPE65 mutations. The AAV-exposed portion of the retina, with the overlying inner retinal blood vessels, appears yellow due to reflective changes in the underlying tapetum.
Credit: Daniel Chung, PhD, University of Pennsylvania School of Medicine; Science Translational Medicine
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