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PMSE brain exhibits abnormal brain architecture. Left, region of the cerebral cortex obtained post-mortem from PMSE patient. Inset depicts neurons trapped in the white matter that have failed to move into the cortex during brain development. Right, three examples of abnormally large neurons in the cerebral cortex in PMSE.

Credit: Peter B. Crino, MD, PhD, University of Pennsylvania School of Medicine

  PMSE brain exhibits abnormal brain architecture. Left, region of the cerebral cortex obtained post-mortem from PMSE patient. Inset depicts neurons trapped in the white matter that have failed to move into the cortex during brain development. Right, three examples of abnormally large neurons in the cerebral cortex in PMSE.
 


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