PHILADELPHIA - Although untreated HIV infection eventually results in immunodeficiency (AIDS), a small group of people infected with the virus, called elite suppressors (0.5 percent of all HIV-infected individuals), are naturally able to control infection in the absence of antiretroviral therapy, or HAART. Elite suppressors and HIV- infected individuals treated with HAART have similar levels of virus in the blood stream. However, levels of HIV integrated into immune cells are much lower in elite suppressors compared to levels in cells from HIV-infected individuals on HAART, according to a study at the Perelman School of Medicine led by Una O'Doherty, MD, PhD, assistant professor of Pathology and Laboratory Medicine, and published in PLoS Pathogens. Graduate student Erin Graf and postdoctoral fellow Angela Mexas, DVM, PhD, are co-first authors on the paper.
For more information, please read the PLoS Pathogens news release.
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