PHILADELPHIA — Gregory Beatty, MD, PhD, an assistant professor in the division of Hematology/Oncology in the Abramson Cancer Center, has received a three-year Clinical Scientist Development Award (CSDA) for $486,000 from the Doris Duke Charitable Foundation to support his clinical research efforts as he works to study the process by which pancreatic cancer spreads in the body and develop new therapies to treat the disease.
“Studies investigating the biology of human pancreas cancer metastasis are lacking,” said Beatty. “The goal of the work funded by the Doris Duke Charitable Foundation will address this critical unmet need by using a comprehensive and collaborative approach to study the role of peripheral blood monocytes as major regulators of the metastatic process in pancreas carcinoma. Peripheral blood monocytes are an attractive and innovative target for impacting tumor metastasis due to their lack of genetic instability and decisive ability to impact tumor biology.”
To conduct this work, Dr. Beatty will lead a team of investigators working to establish the necessary clinical data to develop monocyte-directed immunotherapies designed to inhibit metastasis and tumor growth in patients with pancreas carcinoma and other solid malignancies.
The CSDA funds physician-scientists who are forming their own research teams and allows them to dedicate 75 percent of their professional time to clinical research. After a scientific review panel selected the top 57 of 292 eligible pre-proposals from junior faculty-level physician-scientists, a second peer-review panel designated 16 final candidates to receive grants. Doris Duke has awarded 218 Clinical Scientist Development Awards since 1998, totaling about $94 million.
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