Announcement
August 1, 2014

Penn Medicine Neuropathologist Receives Doris Duke Grant to Study Brain Disorders

PHILADELPHIA — Edward B. Lee, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania, has received a three-year Clinical Scientist Development Award (CSDA) for $486,000 from the Doris Duke Charitable Foundation to support his research in frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS).

Lee heads the Translational Neuropathology Research Laboratory, which aims to understand the root causes of neurodegenerative diseases to develop specific disease-modifying therapies. The lab employs an interdisciplinary approach to address the mechanisms of neurodegeneration, using and developing such cutting-edge techniques as high-resolution, multi-spectral, 3-dimensional confocal imaging and next-generation sequencing.

This award will allow Lee to study a mutation in the C9orf72 gene, the most common genetic cause of frontotemporal degeneration and ALS. With collaborators at the Center for Neurodegenerative Disease Research, the ALS Center at Pennsylvania Hospital, and the PENN FTD Center, Lee will determine how epigenetic modifications of C9orf72 affect disease pathogenesis.  

Lee earned his medical degree and a doctorate in 2005 from the Perelman School of Medicine and completed his Anatomic Pathology residency and his Neuropathology fellowship at the Hospital of the University of Pennsylvania. He is also the recipient of the 2012 Excellence in Science Award from the American Society for Investigative Pathology.

The CSDA funds physician-scientists who are forming their own research teams and allows them to dedicate 75 percent of their professional time to clinical research. Since 1998, the Doris Duke Foundation has awarded 235 CSDAs, with 17 recipients this year.

To learn more about the CSDA, visit www.ddcf.org.

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Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 17 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $392 million awarded in the 2013 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; Chester County Hospital; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Chestnut Hill Hospital and Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2013, Penn Medicine provided $814 million to benefit our community.

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