Characteristic clinical features of fibrodysplasia
ossificans progressiva (FOP). (Left) Extra-skeletal bone formation
in a three-dimensional reconstructed computed tomography scan of
a 12-year-old child. (Right) Radiograph of the feet of a 3-year-old
child showing the symmetrical great toe malformations.
Image Credit: Eileen Shore, PhD and Frederick Kaplan, MD, University
of Pennsylvania School of Medicine; Nature Genetics, 23 April
2006, DOI: 10.1038/ng1783