| February 22,
Hormone Replacement Therapy May Help
Prevent Chronic Wounds in Elderly Patients
PA) -- The question of whether post-menopausal women
should subscribe to Hormone Replacement Therapy (HRT)
is one of the most controversial issues in medicine
today, as scientists debate the benefits and risks associated
with taking estrogen over an extended period.
Now, research at the University of Pennsylvania School
of Medicine has revealed another possible plus for
HRT: Older patients taking estrogen may be significantly
less likely to suffer from two of the most common and
slow-to-heal wounds that afflict the elderly: pressure
ulcers (often described as "bed sores") and
venous leg ulcers.
The finding by David Margolis, MD, PhD, Associate
Professor of Dermatology at Penn, is published this
week in the journal The Lancet.
For the Study, Margolis reviewed the records of 44,195
"Our research indicates that patients receiving
HRT are around 35 percent less likely to develop a venous
leg ulcer or pressure ulcer, which we view as early
evidence that HRT may have a place in preventing chronic
wounds," said Margolis, who holds a secondary appointment
in Penn's Department of Biostatistics and Epidemiology.
The study was funded by the National Institute of Arthritis,
Muscular, Skeletal and Skin Diseases, which is part
of the National Institutes of Health.
Others who participated in the study are: Warren
Bilker, PhD, Assistant Professor of Biostatistics
and Epidemiology, and Jill Knauss, MA, in the
Department of Biostatistics and Epidemiology.