Newsroom | News Archive | Publications | Contact Us for Experts  
FEBRUARY 16, 2006
  Penn Researchers Discover Second Molecular Pathway that Promotes Cell Survival During Low Oxygen Conditions
Back to Article
Image    1

Cells starved for oxygen exhibit decreased energy levels and therefore, activate an energy sensor called “AMP-activated protein kinase” (AMPK). AMPK inhibits mTOR activity and thus simultaneously inhibits cell growth, cell division, and protein synthesis. These are important pathways for the conservation of intracellular energy stores to allow cells to survive the stress of oxygen deprivation.

Image Credit: Celeste Simon, PhD, University of Pennsylvania School of Medicine, Howard Hughes Medical Institute

About Penn Medicine   Contact Us   Site Map   Privacy Statement   Legal Disclaimer   Terms of Use

Penn Medicine, Philadelphia, PA 800-789-PENN © 2016, The Trustees of the University of Pennsylvania