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July 7, 2005

Mood Lighting: Penn Researchers Determine Role of Serotonin in Modulating Circadian Rhythm

Proposed model for the effect of serotonin molecular signaling in fruitfly clock cells. Serotonin binds to its receptor, d5-HT1B, setting off a cascade of events within the cell that involves the clock proteins SGG, TIM, PER, and CRY, and governs the fly's circadian response to light. Alternations in the level of the serotonin receptor affects molecular and behavioral responses of the fly to light.

Credit: Amita Sehgal, University of Pennsylvania School of Medicine and Cell Press

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