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March 14, 2003

Yassine Amrani, PhD, Joins the Department of Medicine at the University of Pennsylvania School of Medicine as a Research Assistant Professor

(Philadelphia, PA) - Yassine Amrani, PhD, has been appointed Research Assistant Professor in the Department of Medicine, Division of Pulmonary, Allergy and Critical Care, at the University of Pennsylvania School of Medicine.

Dr. Amrani holds a Masters of Science degree in Cellular Biology from the University of Constantine in Algeria and earned a Masters of Science degree in Pharmacology, as well as a Doctor of Philosophy degree in Pulmonary Pharmacology, from the University of Strasbourg I in France.

His primary research focuses on understanding the cellular and molecular mechanisms that regulate bronchial hyper-responsiveness, a defining characteristic of allergic asthma. Dr. Amrani was amongst the first in the field to suggest that abnormalities in airway smooth muscle, an important tissue in regulating the bronchomotor tone in healthy conditions, may play an important role in the development of the non-specific bronchial hyper-responsiveness in asthma to pharmacological agents. These findings showed that targeting airway smooth muscle may serve as a new potential therapeutic approach for the treatment of chronic lung diseases. Dr. Amrani's research is supported by the Parker B. Francis Fellowship for Pulmonary research and grants from the American Lung Association and the National Institutes of Health. His research has been published in the European Journal of Pharmacology, the British Journal of Pharmacology, the American Journal of Respiratory Cell and Molecular Biology, the Faseb Journal, the Journal of Clinical Investigation and the Journal of Immunology, among others.

Dr. Amrani is a member of the American Society for Pharmacology and Experimental Therapeutics and the American Association of Immunologists. He is an ad-hoc reviewer for many journals including the American Journal of Physiology and the Journal of Immunology. Among his many accolades, he has received Fellowship Awards from the Association Claude Bernard, the Fondation pour la Recherche Médicale, and the Association Francaise pour la Recherché Thérapeutique, all in Paris, France.

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