Newsroom | News Archive | Publications | Contact Us for Experts  
NOVEMBER 27, 2005
  Homing In On HIV’s Chromosome Target: AIDS Virus Inserts Into Human Genome Using a DNA-Associated Protein
Back to Article
Image    1

LEDGF, a human DNA-associated protein, is the first example of a cellular protein controlling the location of HIV integration in human cells. The red cylinder is an HIV integration complex. The green box is LEDGF, acting as a tether by binding to both HIV integrase and a cellular chromosome.

Image Credit: Frederic Bushman, PhD, University of Pennsylvania School of Medicine

About Penn Medicine   Contact Us   Site Map   Privacy Statement   Legal Disclaimer   Terms of Use

Penn Medicine, Philadelphia, PA 800-789-PENN © 2016, The Trustees of the University of Pennsylvania