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NEWS RELEASE
NOVEMBER 27, 2005
  Homing In On HIV’s Chromosome Target: AIDS Virus Inserts Into Human Genome Using a DNA-Associated Protein
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Image    1
   

LEDGF, a human DNA-associated protein, is the first example of a cellular protein controlling the location of HIV integration in human cells. The red cylinder is an HIV integration complex. The green box is LEDGF, acting as a tether by binding to both HIV integrase and a cellular chromosome.

Image Credit: Frederic Bushman, PhD, University of Pennsylvania School of Medicine




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