PA) - Earlier this month, Mark I. Greene MD, PhD,
the John Eckman Professor of Medical Science at the University
of Pennsylvania School of Medicine, was awarded the J.
Allyn Taylor International Prize in Medicine. The award is given
by the Robarts Research Institute, which is based in London, Ontario,
Canada. The prize is awarded annually to scientists who have made
significant contributions to a field within one of Robarts’
principal areas of research.
Greene was awarded for his pioneering work leading to the development
of Herceptin, the breast cancer drug that defines a new class of
targeted cancer therapies. For more than 25 years, his research
has focused on the molecular processes that underlie the development
of breast and other cancers. His early work described how the activation
of a particular receptor complex on the surface of cells led to
the formation of aggressive breast tumors. His group then discovered
how to disable this cancer-causing receptor complex. This paved
the way for his and other laboratories to develop targeted antibodies
and small molecules to block these receptors and stop tumor growth,
without harming adjacent non-cancerous cells, as with chemotherapy
or radiation. Greene is currently exploring the potential of targeted
therapies to prevent cancer recurrence and treat advanced malignancies.
“The Taylor Prize is one of the few major international prizes
for basic science and I am delighted to have received it,”
He received $10,000 (Cdn), a medallion, and a certificate of merit
at the Institute’s 20th Anniversary Dinner.
PENN Medicine is a $2.9 billion enterprise
dedicated to the related missions of medical education, biomedical
research, and high-quality patient care. PENN Medicine consists
of the University of Pennsylvania School of Medicine (founded in
1765 as the nation's first medical school) and the University of
Pennsylvania Health System.
Penn's School of Medicine is ranked #2 in the nation for receipt
of NIH research funds; and ranked #3 in the nation in U.S. News
& World Report's most recent ranking of top research-oriented
medical schools. Supporting 1,400 fulltime faculty and 700 students,
the School of Medicine is recognized worldwide for its superior
education and training of the next generation of physician-scientists
and leaders of academic medicine.
The University of Pennsylvania Health System includes three hospitals,
all of which have received numerous national patient-care honors [Hospital
of the University of Pennsylvania; Pennsylvania Hospital, the nation's
first hospital; and Penn Presbyterian Medical Center]; a faculty practice
plan; a primary-care provider network; two multispecialty satellite
facilities; and home care and hospice.