Newsroom | News Archive | Publications | Contact Us for Experts  
SEPTEMBER 21, 2005
  Tissue Stiffness Drives Tumor Formation
Back to Article
Image    1

Extracellular matrix stiffness influences tissue growth and changes in function by modulating cell contractility. For example, as stiffness increases in connective tissue, the cells of a normal breast duct (panel 1, left) start to behave aberrantly, causing the structure of the duct to degrade (panel 2, center), as the uncontrolled cell growth of duct-lining cells invade the duct tube (panel 3, right).

Credit: Matthew Naszek, University of Pennsylvania School of Medicine; Cell Press

About Penn Medicine   Contact Us   Site Map   Privacy Statement   Legal Disclaimer   Terms of Use

Penn Medicine, Philadelphia, PA 800-789-PENN © 2016, The Trustees of the University of Pennsylvania