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Abramson Gift Will Build Cancer Research Center
"To give away money is an easy matter and in any man's
power. But to decide to whom to give it, and how large and when, and for
what purpose and how, is neither in every man's power nor an easy
matter." -- Aristotle
On December 11, Leonard and Madlyn Abramson pledged $100 million to
establish the Leonard and Madlyn Abramson Family Cancer Research Institute
at the University of Pennsylvania Cancer Center. The gift is the most
generous single contribution to any of the country's 31 comprehensive cancer
centers that receive federal funds, and it is among the largest donations
Penn has ever received.
John H. Glick, M.D., the Leonard and Madlyn Abramson Professor of
Clinical Oncology and director of the Cancer Center, was named the
director of the
Abramson Family Cancer Research Institute. Glick has been Madlyn Abramson's
personal physician for 12 years, and he saw her through her own battle with
cancer.
According to Judith Rodin, Ph.D., Penn's president, the new center
"will create a revolutionary framework for fostering innovation in cancer
research" through a "collaborative, interdisciplinary and entrepreneurial
effort" of top-ranked scientists and physicians. To goal is to develop new
approaches "that will render current treatments obsolete."
"There is no longer any question on whether we can cure cancer; the
question
now is when," said Glick. "I am more confident than ever that the next
decade will bring us significantly closer to answering this question in an
optimistic way for every patient we treat."
Glick noted that the initial areas of focus would be cancer genetics,
preclinical modes of cancer, detection technologies, tumor diagnostics, and
novel therapeutics. The institute will be targeting the five most common
cancers: of the breast, the lungs, the prostate, and the ovaries, as well as
gastrointestinal tumors.
"Our goal is to treat every patient as if they were a member of our own
family," Glick said.
Leonard Abramson is the founder and former chairman of U.S.
Healthcare, one
of the nation's largest and most successful managed-care organizations. He
sold it to Aetna Inc. in 1996.
Reports began December 11.
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The Indian Express (New Delhi)
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Reuters
Associated Press |
A New Gene-Therapy Approach for HIV
Combination drug therapies to treat HIV infection have been proven
successful in lowering levels of the virus in the body, sometimes to
undetectable levels. But studies show that the virus is not completely
eradicated by these treatments, so patients are not considered "cured" and
must remain on therapy for the rest of their lives.
In the search for an improved treatment, researchers at the University of
Pennsylvania Medical Center report the development of a new gene-therapy
strategy to specifically target cells infected with HIV for attack. The new
tactic commandeers the molecular tools that HIV uses to enter and infect
cells and employs these against the virus as part of a system to deliver
therapeutic genes to only those cells harboring the virus.
"Viruses carry molecules on their envelopes that help them bind to
receptors
on the cell types they infect," explained James A. Hoxie, M.D.,
professor of
medicine and senior author of the study. "We've switched things around,
putting the relevant receptors on a retroviral vector that is able then to
target the cells infected by HIV."
The result is a "hunter virus" that ignores normal cells and targets and
attacks infected macrophages (the cells infected in the earliest stage of
infection) and infected T-cells (the cells infected in later stages of
infection).
"People have developed a number of genetic constructs that could be
used to
block HIV replication," noted Michael J. Endres, Ph.D., a postdoctoral
researcher in Hoxie's laboratory. "But the problem has been that no one has
had a way to effectively reach infected cells with this material--and that's
what this is about."
Reports began November 20.
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Gazette (Montreal, Canada)
Saturday Star (Toronto, Canada)
Washington Post
Atlanta Republic
Eagle (Reading, PA) |
Napping With Your Boss's Blessing
It used to be that workers could get in trouble for nodding off at
work. But
now some progressive companies are incorporating naptime into workers' daily
schedules, allowing them to slip away at designated times to sleep for a
short period -- usually 40 or 45 minutes. According to the Washington
Post,
a company called 42 IS Consulting, a computer consulting firm based in
Berkeley, Calif., encourages naps, believing that resting keeps employees
"sane and healthy." The firm has even set up a napping loft with a
queen-size bed.
"There is a natural tendency, which is biologically driven, to get
tired in
a work atmosphere," David Dinges, Ph.D., associate professor of
psychology
in psychiatry and director of the experimental psychiatry unit at the
University of Pennsylvania School of Medicine, told the Washington
Post.
"There is no question that workers would be better off if they're allowed to
sleep for 25 minutes. Naps enhance morale, performance, production, and
safety." Naps are especially beneficial for workers who work odd hours or
shift work. Still, Dinges said, "companies have the right to expect workers
to come into the office reasonably well rested."
Nap policies are still not very popular among most mainstream companies,
Dinges added. "Most offices don't accept naps as part of work. The reason it
hasn't gone as far in the United States is because we're bogged down in the
American view that sleep isn't productive."
Reports began December 7.
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NATIONAL
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Hospital and Healthcare News
Profiles in Healthcare Marketing |
Health Care Information at the Click of a Mouse
The University of Pennsylvania Health System's health-information web site
provides consumers with health tips, advice for managing chronic diseases,
chat sessions with Penn physicians, listings of educational seminars,
support groups, and special events, and listings of Penn primary care
physicians and specialists. Users can even tap into maps that will direct
them to physicians' offices. In September, 1997, the site encountered
381,625 hits, according to Profiles in Healthcare Marketing. And recently,
UPHS joined forces with Digital City Philadelphia to provide an online
health-information site to American Online members. UPHS will serve as the
exclusive healthcare provider for the new site.
"This relationship helps the University of Pennsylvania Health System
maintain a committed connection with the on-line community, locally and
globally," said William N. Kelley, M.D., CEO of Penn's Health
System and
dean of the School of Medicine. "This is an innovative venture that provides
on-line users a gateway to credible health-related information from a
national healthcare leader."
The site can be accessed at http://health.upenn.edu. America Online
subscribers can access the site with the keyword: Penn Health.
Reports began in November.
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ABC World News Tonight
Philadelphia Business Journal
Philadelphia Daily News
Recorder (Conshohocken, PA)
Marcus Hook Press
KYW-TV3 |
Parkinson's Patients Helped by Man's Best Friend
Kathy Koch, a director at SmithKline Beecham, volunteers her
time at Independence Dogs, a training school in Chadds Ford, Pa., that
provides
service dogs for children and adults with mobility impairments such as
muscular dystrophy, multiple sclerosis, polio, cerebral palsy, and
spinal-cord injuries. According to Philadelphia Business Journal, it
was her
idea to pair the agency's dogs with people with Parkinson's disease as well.
Because the debilitating neurological disorder causes tremors and impaired
balance, people with Parkinson's who are out walking sometimes draw stares
and whispers from strangers who think they are drunk or demented.
When Koch approached Matthew B. Stern, M.D., director of the
Parkinson's
Disease and Movement Disorders Center at Pennsylvania Hospital, with her
idea, he was intrigued. "We are constantly looking for ways to improve the
care of Parkinson's patients." The dogs could be used to help patients keep
from falling as much and help them get back up more easily and regain their
balance.
The dogs could also be trained to sense when the Parkinson's patients were
about to "freeze," a phenomenon in which patients suddenly stop moving and
freeze in place. The trained dogs can walk in front of the patient and tap
him or her on the foot. Said Stern, "That breaks the cycle, and they can
continue moving."
SmithKline provided a grant of $50,000 to train the first five dogs
and has
agreed to provide funding to help the program continue for another year.
Stern plans to develop objective measures to test how the animals help the
quality of life for Parkinson's patients. According to the
Journal, he hopes
that data can be used to secure additional money to expand the program and
train more dogs.
Reports began November 20.
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USA Today
Newsday
Chicago Tribune
Seattle Times
Tampa Tribune
Gazette (Bedford, PA)
CNN
ABC
CBS
Fox News Channel
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WPVI-TV6
KXAS-TV5 |
Birth of Septuplets Triggers Much Discussion
One of the biggest news stories of 1997 was the birth of septuplets to an
Iowa couple, Kenny and Bobbi McCaughey. The four boys and the three
girls
are only the second set of septuplets known to be born alive. When it was
revealed that Bobbi McCaughey had conceived after taking the fertility
medication Pergonal, physicians and ethicists were called on to examine the
business of treating infertility.
Some questioned the judgement of Bobbi McCaughey's physician, after
she let
the couple proceed with treatment even though a pre-ovulation ultrasound
showed that Bobbi would release a very high number of ova. Others discussed
the extremely high cost of prenatal care and caring for the babies after
birth.
Arthur Caplan, Ph.D., director of the Center for Bioethics, spoke
to USA
Today about the pressure placed on competitive infertility clinics to
produce high success rates, sometimes at any cost. "The pressure is on to
have good numbers for making babies and people are not penalized for making
multiple babies," Caplan said. "This is an extremely lucrative business.
It's an absolute cash cow."
Glenn McGee, Ph.D., assistant professor of bioethics for Penn's
School of Medicine and senior fellow in health economics at Penn's
Leonard Davis
Institute, told NBC's Nightside, "There is more regulation for circus animal
treatment than for infertility research in America."
Another bioethicist, David Magnus, Ph.D., graduate studies
director for the
Center for Bioethics and associate professor of cellular and molecular
engineering and philosophy, expressed his concerns on MSNBC.
"There are several ways in which I think this is potentially dangerous.
It is very
costly, there are risks, and there are forty specialists involved in this
care. We're spending an awful lot of money at a time when there are a lot of
children who aren't getting any needed treatment."
"It's great that these babies seem to be doing well and the mom is doing
well," said Caplan in an appearance on ABC's This Week. But Caplan
went on
to talk about limits. "We've got no ground rules, not even minimal limits
just to say, standardize the informed consent. . . . And, maybe, let's put
some constrictions on who can use this technology. For example, do you have
to be infertile to use it? What if I just wanted, as a woman, to make seven
babies just because I want to be a celebrity? Right now, there is nothing to
stop that."
Reports began November 10.
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Time
ABC
CNN Your Health
Boston Globe
KYW-TV3 |
Scientific Support for Acupuncture
Acupuncture has been used in China for at least 3,000 years to treat
illness
and pain. And while American physicians have traditionally been skeptical of
the treatment, many now consider it a viable option.
In early November, a federal panel convened to review acupuncture and
concluded that, for some ailments, acupuncture is an effective treatment.
Their decision was partially based on evidence that acupuncture appears to
alleviate the nausea of pregnancy and chemotherapy and the pain of dental
surgery. It may also work against drug addiction, headaches, and menstrual
cramps. However, the panel concluded that there was not overwhelming
evidence that acupuncture could help with lower back pain and asthma.
"We did not find that acupuncture was a panacea," said Majorie
Bowman, M.D.,
chair of the department of family practice and community medicine. "But we
did find evidence that it worked for some areas."
Michael Cirigliano, M.D., assistant professor of medicine, told
KYW-TV3, "If
someone wants to see an acupuncturist for a particular pain syndrome, as
long as they've been fully evaluated and a proper diagnosis has been
made, I think complementary medicine is wonderful."
The panel urged broader coverage from private insurers and the government
for the alternative treatment. Acupuncture treatments cost about $70 a
session.
Reports began November 5.
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ReutersHealth Online
Biomed Technology
Nashville Banner |
Optimizing Working Memory
Short-term, or working, memory acts like a mental triage, of sorts. A
small
part of the brain in the prefrontal cortex is responsible for coordinating
ephemeral sights, sounds, and smells before they are jettisoned or reserved
for long-term keeping. Understanding the neurochemistry of how the brain's
version of Post-It Notes (TM) works has long been the subject of intense
research.
Recent studies have demonstrated a role for the neurotransmitter
dopamine in orchestrating aspects of short-term memory.
Now, a team of neuroscientists from the University of Pennsylvania Medical
Center have demonstrated -- for the first time -- that a dopamine-like drug
called bromocriptine can improve higher-level cognitive functions. What's
more, the effects of bromocriptine depend on a person's baseline short-term
memory capacity.
"Our a priori hypothesis was that the drug would improve performance in
normal subjects," remarked Daniel Y. Kimberg, Ph.D., a post-doctoral
fellow in the department of neurology, and lead author of the study.
"After running
a couple of pilot studies, we noticed that subjects who did better on a
reading memory test scored worse when performing the test a few hours after
taking bromocriptine, and the ones who didn't do so well on the test seemed
to improve on the drug."
When the subjects were divided into two groups based on their
reading-memory-test scores, high-capacity subjects performed more poorly on
four other tests that measure different aspects of working memory after
taking bromocriptine; whereas, the scores of low-capacity subjects improved.
The findings suggest that there is an optimal level of dopamine for
short-term memory to function properly, and at high levels of working memory
capacity and/or dopamine found naturally in the brain, adding more dopamine
to the system impairs rather than enhances performance.
Reports began November 26.
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Boston Globe
Denver Post
Rocky Mountain News |
Calming, Not Sedating, Aggressive Alzheimer's Patients
An unfortunate complication of Alzheimer's disease is aggression and
dementia, and in many cases, this leads to attacks on loved ones or
nursing-home workers. And while restraints and sedation are usually used to
control the problem, scientists continue to look for ways to calm these
patients without making them blurry-minded.
Now, a recent study has found that the schizophrenia medicine
risperidone is
effective in treating Alzheimer's related dementia and aggression. Ira
Katz,
M.D., Ph.D., professor of psychiatry and lead investigator of the
study of
625 patients in 40 United States nursing homes and hospitals, is hopeful.
"With a safer agent, we can really begin more use of the medicine not just
to keep the [nursing home] aide from being slugged, but to help the patient
enjoy life more."
One 83-year-old study participant was a stroke patient who had been
extremely combative with the workers in his nursing home. When the patient
was treated with risperidone, he was able to cheerfully live out his last
months.
Risperidone helped 36 percent of the study patients have a 60 percent
reduction in psychotic symptoms. This was not substantially greater than the
group receiving placebos, in which 22 percent experienced a reduction in
symptoms, but still significant. Both groups received psychological
counseling, which is known to reduce symptoms. Katz said that risperidone's
great advantage is that is does not cause sedation, as most other treatments
do.
Reports began December 11.
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United Press International
Chicago Tribune
Arizona Republic |
3-D Technology Could Reduce Breast Biopsies
When a woman is told that her mammogram is "suspicious," she is almost
always subjected to subsequent breast tissue biopsy. Now, a new computer
imagery that gives doctors a three-dimensional view of abnormalities in
breast tissue may reduce the need for the invasive procedure.
At the Radiological Society of North America meeting in Chicago in
December,
Emily Conant, M.D., associate professor of radiology and chief of the
breast-imaging division, and her co-researcher Andrew Maidment, MD,
director
of radiology imaging physics at Thomas Jefferson University Hospital, told
attendees that computer technology can determine the status of half of all
suspicious calcifications, preventing the need for thousands of biopsies.
The technology works by manipulating digital images so that physicians can
watch them rotate in three dimensions on a computer screen. The technology
used in the study is currently in use to position needles that extract
sample tissue from breasts, Conant said.
In Maidment's study of 44 suspicious mammograms, researchers were able to
correctly pinpoint 14 cancers, and were correct in ruling out 18 of 30 other
suspicious lumps. All the women in the study were scheduled for biopsies,
but they agreed to undergo the additional procedure as part of the study.
"Breast biopsies are physically and emotionally traumatic for women,"
Conant
said. "If we can improve the accuracy of our mammography diagnoses, we can
reduce the number of unnecessary biopsies. We believe this new technology
will allow this advance."
Reports began December 2.
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PERSPECTIVES
"I have the best people in the world and delegate fully
to them."
--William N. Kelley, M.D., CEO of Penn's Health System and dean of the
School of Medicine
"Executive Decisions: Tips From the Top"
Philadelphia, December 1997
"People might imagine that an evil government would
be the one to use personality-perfecting drugs to weed out bad behavior
in kids. But actually, it'll be legions of nervous, competitive parents."
--Arthur L. Caplan, Ph.D., director of Penn's Center for
Bioethics
"Generation Rx"
Philadelphia, December 1997
"People would like to get down to an ideal weight.
They'd like to look like Cindy Crawford. This medication's not going to
help them do that."
--Thomas A. Wadden, Ph.D., professor of psychology in psychiatry
and director of Penn's Weight and Eating Disorders Program Subject:
The New Diet Drug "Meridia"
WPVI-TV6's Action News, 11/25
"This is like using a 1992 Consumer Reports
automobile magazine to buy a 1998 model."
--David Shulkin, M.D., chief medical officer/chief quality
officer of the Health System
"Transplant Survival is Greatly Improved"
The Philadelphia Inquirer, 12/13
"If we can't tell right away in person, how well can
even an experienced physician tell over the phone?"
--Robert A. Lowe, M.P.H., M.D., assistant professor of emergency
medicine
Subject: Has Overly-Zealous Gatekeeping Resulted in Complications or Death?
WPVI-TV6's Action News, 12/3
SNIPS & CLIPS
BRAIN ATTACKS. . . A public service campaign by the National Stroke
Association is working to raise Americans' awareness of stroke, the third
leading cause of death. Eric Raps, M.D., associate professor of
neurology,
spoke on WPHL-TV17's Community Close-Up about what to look for. "I
want to
emphasize the importance not only of knowing the warning signs of stroke
[including headache, numbness or weakness of one side of the body, and
slurring of speech] but knowing that treatment is available," Raps said.
Medical research over the last two decades has shown that a window of
opportunity exists and if a patient gets prompt therapy within that brief
window of several hours, the deficits can often be completely reversed."
Aired December 22.
PREDICTING BALDNESS. . . Men who are trying to guess whether or
not
they will bald can look to their family trees for clues. Baldness can be
inherited through the mother's side and the father's side. One other sign of
future baldness is unusual whiskers that are wispy, sparse and curly and
appear on the temples and sideburns. "People who have those whiskers tend to
get relatively extreme hair loss," Leonard Dzubow, M.D., professor of
dermatology," told Details magazine. "Fortunately, it's not that
common." Printed in the December issue.
DESTRESSING KIDS. . . A death in the family, divorce, or family
financial
problems can be terrifying for children. What can parents do to help? Here
are some suggestions from Jerilynn Radcliffe, Ph.D., assistant
professor of
pediatrics and director of preschool assessment services at Children's
Seashore House, who talked about handling crises in Woman's Day.
Parents
should answer children's questions simply and honestly, keep household
routines as normal as possible, use religious messages to comfort children,
and read books to children about families who have had similar experiences.
Printed in the October issue.
WHAT'S BEST? . . . The American Academy of Pediatrics recently
released new
guidelines urging women to breastfeed their babies for at least a year.
Currently, only one-fifth of women in this country nurse their babies for as
long as six months -- and many supplement their breast milk with baby
formula. Will the new guidelines convince more women to breastfeed?
Pennsylvania Hospital pediatrician Cathy Buch, M.D., told The
Philadelphia
Inquirer, "I basically think nothing is going to change other than the
number of calls we get from women asking, 'Am I doing the right thing?'" For
many women -- particularly those who work outside the home -- it's difficult
to incorporate breastfeeding into their busy schedules. "What I say to my
patients who feel they can't breastfeed for whatever reason is: Look at us.
We were primarily a bottle-fed generation and we're going great," Buch
added. Printed December 8.
FEEL RIGHT AT HOME. . . The Philadelphia Business Journal
named Penn
Medicine at Radnor co-winner of its Building Excellence Award in the public
building category. Citing such features as natural lighting and cherry
casework, the Journal described the Radnor facility as "a warm and pleasant
environment where patients would feel welcomed." M. Lois Mathison, a
designer with the architectural firm that planned the site, explained,
"Every area is designed to help patients relax. The infusion therapy
[chemotherapy] area, for instance, overlooks a beautifully landscaped area,
sensitive to the duration of patients' visits." Printed in the November
14-20 issue.
PUMPKIN APPEAL. . . Penn's Center for Human Appearance offers a
natural way
to improve your complexion: a pumpkin peel. "Pumpkin is very similar to the
skin in that it holds water," Betsy Rubenstone, a paramedic
aesthetician
affiliated with the Center, told WPVI-TV's Action News. Like alpha
hydroxy acid peels, pumpkin peels help remove dead skin cells. But the
pumpkin peel
offers other benefits. "Pumpkin has a lot of vitamin A, a lot of vitamin C,
beta-carotene, beta-glucin, all the wonderful antioxidants that the skin
benefits from," Rubenstone explained. Aired November 10.
WHEN THEY WON'T PAY. . . Gatekeeping -- the process by which many
HMOs
authorize or deny reimbursement of emergency care for their insured patients
-- may contribute to adverse clinical outcomes, new research shows. In a
study examining the safety of emergency-care gatekeeping, Robert A. Lowe,
M.P.H., M.D., assistant professor of emergency medicine, and an Oregon
colleague found that nearly-one third of patients who were denied telephone
pre-authorization for emergency medical care suffered adverse clinical
outcomes or were put at an increased risk of death or disability. Lowe
advises the insured to make sure they know their managed care company's
policies. "If your managed care organization creates barriers so you can't
get in to see your doctor when you need to, find a managed care organization
that cares about your access to care. And they're out there," he told
Channel 10's News Ten. Aired November 19.
MY CHILD, MY TWIN. . . Should cloning be offered as an option to
couples who
are unable to have children? "My hunch is this is probably going to be a
little frightening, a little too disturbing from the child's point of view,"
Arthur Caplan, Ph.D., director of Penn's Center for Bioethics, told
KYW-TV's
News 3. According to Caplan, the heated debate surrounding the
issue is telling. "Why are so many people worried about it? I think it
tells us some
of the fears we have about genetics, about science, about not trusting that
people are going to use technologies wisely," he said. Aired November 11.
STERILIZATION ETHICS. . . Drug-addicted women in California are
being
offered money to undergo tubal ligations, according to FNC's Fox News
Now.
The women who participate sign a consent form. But is the procedure really
voluntary, given the often desperate circumstances of these women's lives?
"Informed consent is more than merely having a piece of paper that you sign.
This is a serious medical procedure that we are talking about, an
irreversible one," said David Magnus, Ph.D., graduate studies
director for
the Center for Bioethics and associate professor of cellular and molecular
engineering and philosophy. "If you are dealing with someone who's a drug
addict being offered a serious financial inducement in a particular context,
that may very well be enough so that it does not constitute informed
consent," he added. Aired November 14.
MAPPING OUT CRAVING. . . Many scientists thought cocaine
addiction was
merely psychological -- not physiological -- because addicts who stop using
the drug do not show signs of withdrawal. But studies by Anna Rose
Childress, Ph.D., associate clinical professor of psychiatry, show that
there is a physiological component of cocaine craving. Childress puts
cocaine addicts into PET (positron-emission topography) scanners to pinpoint
brain activity, and then shows them films of people using drugs. "Their
hearts pitty-pat, they get light-headed, some even experience a minor
euphoria," Childress told The Philadelphia Inquirer. And the PET scans
reveal that the pleasure centers in addicts' brains light up when watching
the drug films. "There's a physical, brain basis to it all," Childress
explained. Printed December 1.
DEATH AND DYING. . . How does a hospital chaplain minister to
patients who
come from various religious backgrounds, and whose beliefs may or may not
align with his? According to the Reverend Ralph Ciampa, director
of the pastoral care, it's really not that difficult. "You have to have
some way of
meeting people at something that is more universal than the particular
beliefs of their given faith group," Ciampa told WPVI-TV6's
Perspective.
"There are particular rituals that are very precious to each religious
group. But beyond that, there's a kind of universal humanness that you can
reach through at these times very, very effectively." Aired November 1.
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MEDIA Review
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February, 1998
Linda Bird Randolph, Editor
Roshonda Jones, Marion Wyce, Staff
Colleen Hughes-Behler, Designer
Administration:
William N. Kelley, MD, CEO, University of Pennsylvania
Medical Center and Health System, and Dean, School of
Medicine
Lori Doyle, Chief Public Affairs Officer
Rebecca Harmon, Director of Media Relations
Media Review is published monthly by the University of
Pennsylvania Medical Center's Office of Public Affairs to
keep the faculty and administration aware of recent Penn-specific
media highlights. To make comments, write to Editor, Media
Review, 220 Blockley Hall, 3400Spruce Street, Philadelphia,
PA 19104
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