Media Review

   February 1998


INTERNATIONAL


Breaking News

USA Today-Europe

USA Today

The New York Times

Washington Post

Atlanta Constitution

Plain Dealer (Cleveland)

The Philadelphia Inquirer

Philadelphia Daily News

Philadelphia Business Journal

Bucks County Courier Times

Patriot-News

Beaver County Times

The American (Somerset, PA)

Citizens' Voice

AHA News

The Gazette (Bedford, PA)

KYW-TV3

WPVI-TV6

WCAU-TV10

KYW-AM1060

Abramson Gift Will Build Cancer Research Center

"To give away money is an easy matter and in any man's power. But to decide to whom to give it, and how large and when, and for what purpose and how, is neither in every man's power nor an easy matter."

-- Aristotle

On December 11, Leonard and Madlyn Abramson pledged $100 million to establish the Leonard and Madlyn Abramson Family Cancer Research Institute at the University of Pennsylvania Cancer Center. The gift is the most generous single contribution to any of the country's 31 comprehensive cancer centers that receive federal funds, and it is among the largest donations Penn has ever received.  

John H. Glick, M.D., the Leonard and Madlyn Abramson Professor of Clinical Oncology and director of the Cancer Center, was named the director of the Abramson Family Cancer Research Institute. Glick has been Madlyn Abramson's personal physician for 12 years, and he saw her through her own battle with cancer.  

According to Judith Rodin, Ph.D., Penn's president, the new center "will create a revolutionary framework for fostering innovation in cancer research" through a "collaborative, interdisciplinary and entrepreneurial effort" of top-ranked scientists and physicians. To goal is to develop new approaches "that will render current treatments obsolete."  

"There is no longer any question on whether we can cure cancer; the question now is when," said Glick. "I am more confident than ever that the next decade will bring us significantly closer to answering this question in an optimistic way for every patient we treat."  

Glick noted that the initial areas of focus would be cancer genetics, preclinical modes of cancer, detection technologies, tumor diagnostics, and novel therapeutics. The institute will be targeting the five most common cancers: of the breast, the lungs, the prostate, and the ovaries, as well as gastrointestinal tumors.  

"Our goal is to treat every patient as if they were a member of our own family," Glick said.  

Leonard Abramson is the founder and former chairman of U.S. Healthcare, one of the nation's largest and most successful managed-care organizations. He sold it to Aetna Inc. in 1996.  

Reports began December 11.


The Indian Express (New Delhi)

Los Angeles Times

Boston Globe

Baltimore Sun

Seattle Times

Philadelphia Daily News

Orange County Register

St. Petersburg Times

San Jose Mercury News

Sun-Sentinel

Tampa Tribune

Fort Worth Star-Telegram

Indianapolis Star

Beaver County Times

Southern Voice

washingtonpost.com

newsday.com

Reuters

Associated Press

A New Gene-Therapy Approach for HIV

Combination drug therapies to treat HIV infection have been proven successful in lowering levels of the virus in the body, sometimes to undetectable levels. But studies show that the virus is not completely eradicated by these treatments, so patients are not considered "cured" and must remain on therapy for the rest of their lives.  

In the search for an improved treatment, researchers at the University of Pennsylvania Medical Center report the development of a new gene-therapy strategy to specifically target cells infected with HIV for attack. The new tactic commandeers the molecular tools that HIV uses to enter and infect cells and employs these against the virus as part of a system to deliver therapeutic genes to only those cells harboring the virus.  

"Viruses carry molecules on their envelopes that help them bind to receptors on the cell types they infect," explained James A. Hoxie, M.D., professor of medicine and senior author of the study. "We've switched things around, putting the relevant receptors on a retroviral vector that is able then to target the cells infected by HIV."

The result is a "hunter virus" that ignores normal cells and targets and attacks infected macrophages (the cells infected in the earliest stage of infection) and infected T-cells (the cells infected in later stages of infection).  

"People have developed a number of genetic constructs that could be used to block HIV replication," noted Michael J. Endres, Ph.D., a postdoctoral researcher in Hoxie's laboratory. "But the problem has been that no one has had a way to effectively reach infected cells with this material--and that's what this is about."  

Reports began November 20.


Gazette (Montreal, Canada)

Saturday Star (Toronto, Canada)

Washington Post

Atlanta Republic

Eagle (Reading, PA)

Napping With Your Boss's Blessing

It used to be that workers could get in trouble for nodding off at work. But now some progressive companies are incorporating naptime into workers' daily schedules, allowing them to slip away at designated times to sleep for a short period -- usually 40 or 45 minutes. According to the Washington Post, a company called 42 IS Consulting, a computer consulting firm based in Berkeley, Calif., encourages naps, believing that resting keeps employees "sane and healthy." The firm has even set up a napping loft with a queen-size bed.  

"There is a natural tendency, which is biologically driven, to get tired in a work atmosphere," David Dinges, Ph.D., associate professor of psychology in psychiatry and director of the experimental psychiatry unit at the University of Pennsylvania School of Medicine, told the Washington Post. "There is no question that workers would be better off if they're allowed to sleep for 25 minutes. Naps enhance morale, performance, production, and safety." Naps are especially beneficial for workers who work odd hours or shift work. Still, Dinges said, "companies have the right to expect workers to come into the office reasonably well rested."  

Nap policies are still not very popular among most mainstream companies, Dinges added. "Most offices don't accept naps as part of work. The reason it hasn't gone as far in the United States is because we're bogged down in the American view that sleep isn't productive."  

Reports began December 7.


NATIONAL


Hospital and Healthcare News

Profiles in Healthcare Marketing

Health Care Information at the Click of a Mouse

The University of Pennsylvania Health System's health-information web site provides consumers with health tips, advice for managing chronic diseases, chat sessions with Penn physicians, listings of educational seminars, support groups, and special events, and listings of Penn primary care physicians and specialists. Users can even tap into maps that will direct them to physicians' offices. In September, 1997, the site encountered 381,625 hits, according to Profiles in Healthcare Marketing. And recently, UPHS joined forces with Digital City Philadelphia to provide an online health-information site to American Online members. UPHS will serve as the exclusive healthcare provider for the new site.  

"This relationship helps the University of Pennsylvania Health System maintain a committed connection with the on-line community, locally and globally," said William N. Kelley, M.D., CEO of Penn's Health System and dean of the School of Medicine. "This is an innovative venture that provides on-line users a gateway to credible health-related information from a national healthcare leader."  

The site can be accessed at http://health.upenn.edu. America Online subscribers can access the site with the keyword: Penn Health.  

Reports began in November.


ABC World News Tonight

Philadelphia Business Journal

Philadelphia Daily News

Recorder (Conshohocken, PA)

Marcus Hook Press

KYW-TV3

Parkinson's Patients Helped by Man's Best Friend

Kathy Koch, a director at SmithKline Beecham, volunteers her time at Independence Dogs, a training school in Chadds Ford, Pa., that provides service dogs for children and adults with mobility impairments such as muscular dystrophy, multiple sclerosis, polio, cerebral palsy, and spinal-cord injuries. According to Philadelphia Business Journal, it was her idea to pair the agency's dogs with people with Parkinson's disease as well. Because the debilitating neurological disorder causes tremors and impaired balance, people with Parkinson's who are out walking sometimes draw stares and whispers from strangers who think they are drunk or demented.  

When Koch approached Matthew B. Stern, M.D., director of the Parkinson's Disease and Movement Disorders Center at Pennsylvania Hospital, with her idea, he was intrigued. "We are constantly looking for ways to improve the care of Parkinson's patients." The dogs could be used to help patients keep from falling as much and help them get back up more easily and regain their balance.  

The dogs could also be trained to sense when the Parkinson's patients were about to "freeze," a phenomenon in which patients suddenly stop moving and freeze in place. The trained dogs can walk in front of the patient and tap him or her on the foot. Said Stern, "That breaks the cycle, and they can continue moving."  

SmithKline provided a grant of $50,000 to train the first five dogs and has agreed to provide funding to help the program continue for another year. Stern plans to develop objective measures to test how the animals help the quality of life for Parkinson's patients. According to the Journal, he hopes that data can be used to secure additional money to expand the program and train more dogs.  

Reports began November 20.


USA Today

Newsday

Chicago Tribune

Seattle Times

Tampa Tribune

Gazette (Bedford, PA)

CNN

ABC

CBS

Fox News Channel

NBC

MSNBC

CNBC

WPVI-TV6

KXAS-TV5

Birth of Septuplets Triggers Much Discussion

One of the biggest news stories of 1997 was the birth of septuplets to an Iowa couple, Kenny and Bobbi McCaughey. The four boys and the three girls are only the second set of septuplets known to be born alive. When it was revealed that Bobbi McCaughey had conceived after taking the fertility medication Pergonal, physicians and ethicists were called on to examine the business of treating infertility.  

Some questioned the judgement of Bobbi McCaughey's physician, after she let the couple proceed with treatment even though a pre-ovulation ultrasound showed that Bobbi would release a very high number of ova. Others discussed the extremely high cost of prenatal care and caring for the babies after birth.  

Arthur Caplan, Ph.D., director of the Center for Bioethics, spoke to USA Today about the pressure placed on competitive infertility clinics to produce high success rates, sometimes at any cost. "The pressure is on to have good numbers for making babies and people are not penalized for making multiple babies," Caplan said. "This is an extremely lucrative business. It's an absolute cash cow."  

Glenn McGee, Ph.D., assistant professor of bioethics for Penn's School of Medicine and senior fellow in health economics at Penn's Leonard Davis Institute, told NBC's Nightside, "There is more regulation for circus animal treatment than for infertility research in America."  

Another bioethicist, David Magnus, Ph.D., graduate studies director for the Center for Bioethics and associate professor of cellular and molecular engineering and philosophy, expressed his concerns on MSNBC. "There are several ways in which I think this is potentially dangerous. It is very costly, there are risks, and there are forty specialists involved in this care. We're spending an awful lot of money at a time when there are a lot of children who aren't getting any needed treatment."  

"It's great that these babies seem to be doing well and the mom is doing well," said Caplan in an appearance on ABC's This Week. But Caplan went on to talk about limits. "We've got no ground rules, not even minimal limits just to say, standardize the informed consent. . . . And, maybe, let's put some constrictions on who can use this technology. For example, do you have to be infertile to use it? What if I just wanted, as a woman, to make seven babies just because I want to be a celebrity? Right now, there is nothing to stop that."  

Reports began November 10.


Time

ABC

CNN Your Health

Boston Globe

KYW-TV3

Scientific Support for Acupuncture

Acupuncture has been used in China for at least 3,000 years to treat illness and pain. And while American physicians have traditionally been skeptical of the treatment, many now consider it a viable option.  

In early November, a federal panel convened to review acupuncture and concluded that, for some ailments, acupuncture is an effective treatment. Their decision was partially based on evidence that acupuncture appears to alleviate the nausea of pregnancy and chemotherapy and the pain of dental surgery. It may also work against drug addiction, headaches, and menstrual cramps. However, the panel concluded that there was not overwhelming evidence that acupuncture could help with lower back pain and asthma.  

"We did not find that acupuncture was a panacea," said Majorie Bowman, M.D., chair of the department of family practice and community medicine. "But we did find evidence that it worked for some areas."  

Michael Cirigliano, M.D., assistant professor of medicine, told KYW-TV3, "If someone wants to see an acupuncturist for a particular pain syndrome, as long as they've been fully evaluated and a proper diagnosis has been made, I think complementary medicine is wonderful."  

The panel urged broader coverage from private insurers and the government for the alternative treatment. Acupuncture treatments cost about $70 a session.  

Reports began November 5.


ReutersHealth Online

Biomed Technology

Nashville Banner

Optimizing Working Memory

Short-term, or working, memory acts like a mental triage, of sorts. A small part of the brain in the prefrontal cortex is responsible for coordinating ephemeral sights, sounds, and smells before they are jettisoned or reserved for long-term keeping. Understanding the neurochemistry of how the brain's version of Post-It Notes (TM) works has long been the subject of intense research.  

Recent studies have demonstrated a role for the neurotransmitter dopamine in orchestrating aspects of short-term memory.  

Now, a team of neuroscientists from the University of Pennsylvania Medical Center have demonstrated -- for the first time -- that a dopamine-like drug called bromocriptine can improve higher-level cognitive functions. What's more, the effects of bromocriptine depend on a person's baseline short-term memory capacity.  

"Our a priori hypothesis was that the drug would improve performance in normal subjects," remarked Daniel Y. Kimberg, Ph.D., a post-doctoral fellow in the department of neurology, and lead author of the study. "After running a couple of pilot studies, we noticed that subjects who did better on a reading memory test scored worse when performing the test a few hours after taking bromocriptine, and the ones who didn't do so well on the test seemed to improve on the drug."  

When the subjects were divided into two groups based on their reading-memory-test scores, high-capacity subjects performed more poorly on four other tests that measure different aspects of working memory after taking bromocriptine; whereas, the scores of low-capacity subjects improved.  

The findings suggest that there is an optimal level of dopamine for short-term memory to function properly, and at high levels of working memory capacity and/or dopamine found naturally in the brain, adding more dopamine to the system impairs rather than enhances performance.  

Reports began November 26.


Boston Globe

Denver Post

Rocky Mountain News

Calming, Not Sedating, Aggressive Alzheimer's Patients

An unfortunate complication of Alzheimer's disease is aggression and dementia, and in many cases, this leads to attacks on loved ones or nursing-home workers. And while restraints and sedation are usually used to control the problem, scientists continue to look for ways to calm these patients without making them blurry-minded.  

Now, a recent study has found that the schizophrenia medicine risperidone is effective in treating Alzheimer's related dementia and aggression. Ira Katz, M.D., Ph.D., professor of psychiatry and lead investigator of the study of 625 patients in 40 United States nursing homes and hospitals, is hopeful. "With a safer agent, we can really begin more use of the medicine not just to keep the [nursing home] aide from being slugged, but to help the patient enjoy life more."  

One 83-year-old study participant was a stroke patient who had been extremely combative with the workers in his nursing home. When the patient was treated with risperidone, he was able to cheerfully live out his last months.  

Risperidone helped 36 percent of the study patients have a 60 percent reduction in psychotic symptoms. This was not substantially greater than the group receiving placebos, in which 22 percent experienced a reduction in symptoms, but still significant. Both groups received psychological counseling, which is known to reduce symptoms. Katz said that risperidone's great advantage is that is does not cause sedation, as most other treatments do.  

Reports began December 11.


United Press International

Chicago Tribune

Arizona Republic

3-D Technology Could Reduce Breast Biopsies

When a woman is told that her mammogram is "suspicious," she is almost always subjected to subsequent breast tissue biopsy. Now, a new computer imagery that gives doctors a three-dimensional view of abnormalities in breast tissue may reduce the need for the invasive procedure.  

At the Radiological Society of North America meeting in Chicago in December, Emily Conant, M.D., associate professor of radiology and chief of the breast-imaging division, and her co-researcher Andrew Maidment, MD, director of radiology imaging physics at Thomas Jefferson University Hospital, told attendees that computer technology can determine the status of half of all suspicious calcifications, preventing the need for thousands of biopsies.  

The technology works by manipulating digital images so that physicians can watch them rotate in three dimensions on a computer screen. The technology used in the study is currently in use to position needles that extract sample tissue from breasts, Conant said.  

In Maidment's study of 44 suspicious mammograms, researchers were able to correctly pinpoint 14 cancers, and were correct in ruling out 18 of 30 other suspicious lumps. All the women in the study were scheduled for biopsies, but they agreed to undergo the additional procedure as part of the study.  

"Breast biopsies are physically and emotionally traumatic for women," Conant said. "If we can improve the accuracy of our mammography diagnoses, we can reduce the number of unnecessary biopsies. We believe this new technology will allow this advance."  

Reports began December 2.


PERSPECTIVES


"I have the best people in the world and delegate fully to them."
  --William N. Kelley, M.D., CEO of Penn's Health System and dean of the School of Medicine
"Executive Decisions: Tips From the Top"
Philadelphia, December 1997
"People might imagine that an evil government would be the one to use personality-perfecting drugs to weed out bad behavior in kids. But actually, it'll be legions of nervous, competitive parents."
--Arthur L. Caplan, Ph.D., director of Penn's Center for Bioethics
"Generation Rx"
Philadelphia, December 1997
"People would like to get down to an ideal weight. They'd like to look like Cindy Crawford. This medication's not going to help them do that."
--Thomas A. Wadden, Ph.D., professor of psychology in psychiatry and director of Penn's Weight and Eating Disorders Program Subject:
The New Diet Drug "Meridia"
WPVI-TV6's Action News, 11/25
"This is like using a 1992 Consumer Reports automobile magazine to buy a 1998 model."
--David Shulkin, M.D., chief medical officer/chief quality officer of the Health System
"Transplant Survival is Greatly Improved"
The Philadelphia Inquirer, 12/13
"If we can't tell right away in person, how well can even an experienced physician tell over the phone?"
--Robert A. Lowe, M.P.H., M.D., assistant professor of emergency medicine
Subject: Has Overly-Zealous Gatekeeping Resulted in Complications or Death?
WPVI-TV6's Action News, 12/3


SNIPS & CLIPS


BRAIN ATTACKS. . . A public service campaign by the National Stroke Association is working to raise Americans' awareness of stroke, the third leading cause of death. Eric Raps, M.D., associate professor of neurology, spoke on WPHL-TV17's Community Close-Up about what to look for. "I want to emphasize the importance not only of knowing the warning signs of stroke [including headache, numbness or weakness of one side of the body, and slurring of speech] but knowing that treatment is available," Raps said. Medical research over the last two decades has shown that a window of opportunity exists and if a patient gets prompt therapy within that brief window of several hours, the deficits can often be completely reversed." Aired December 22.  

PREDICTING BALDNESS. . . Men who are trying to guess whether or not they will bald can look to their family trees for clues. Baldness can be inherited through the mother's side and the father's side. One other sign of future baldness is unusual whiskers that are wispy, sparse and curly and appear on the temples and sideburns. "People who have those whiskers tend to get relatively extreme hair loss," Leonard Dzubow, M.D., professor of dermatology," told Details magazine. "Fortunately, it's not that common." Printed in the December issue.  

DESTRESSING KIDS. . . A death in the family, divorce, or family financial problems can be terrifying for children. What can parents do to help? Here are some suggestions from Jerilynn Radcliffe, Ph.D., assistant professor of pediatrics and director of preschool assessment services at Children's Seashore House, who talked about handling crises in Woman's Day. Parents should answer children's questions simply and honestly, keep household routines as normal as possible, use religious messages to comfort children, and read books to children about families who have had similar experiences. Printed in the October issue.  

WHAT'S BEST? . . . The American Academy of Pediatrics recently released new guidelines urging women to breastfeed their babies for at least a year. Currently, only one-fifth of women in this country nurse their babies for as long as six months -- and many supplement their breast milk with baby formula. Will the new guidelines convince more women to breastfeed? Pennsylvania Hospital pediatrician Cathy Buch, M.D., told The Philadelphia Inquirer, "I basically think nothing is going to change other than the number of calls we get from women asking, 'Am I doing the right thing?'" For many women -- particularly those who work outside the home -- it's difficult to incorporate breastfeeding into their busy schedules. "What I say to my patients who feel they can't breastfeed for whatever reason is: Look at us. We were primarily a bottle-fed generation and we're going great," Buch added. Printed December 8.  

FEEL RIGHT AT HOME. . . The Philadelphia Business Journal named Penn Medicine at Radnor co-winner of its Building Excellence Award in the public building category. Citing such features as natural lighting and cherry casework, the Journal described the Radnor facility as "a warm and pleasant environment where patients would feel welcomed." M. Lois Mathison, a designer with the architectural firm that planned the site, explained, "Every area is designed to help patients relax. The infusion therapy [chemotherapy] area, for instance, overlooks a beautifully landscaped area, sensitive to the duration of patients' visits." Printed in the November 14-20 issue.  

PUMPKIN APPEAL. . . Penn's Center for Human Appearance offers a natural way to improve your complexion: a pumpkin peel. "Pumpkin is very similar to the skin in that it holds water," Betsy Rubenstone, a paramedic aesthetician affiliated with the Center, told WPVI-TV's Action News. Like alpha hydroxy acid peels, pumpkin peels help remove dead skin cells. But the pumpkin peel offers other benefits. "Pumpkin has a lot of vitamin A, a lot of vitamin C, beta-carotene, beta-glucin, all the wonderful antioxidants that the skin benefits from," Rubenstone explained. Aired November 10.  

WHEN THEY WON'T PAY. . . Gatekeeping -- the process by which many HMOs authorize or deny reimbursement of emergency care for their insured patients -- may contribute to adverse clinical outcomes, new research shows. In a study examining the safety of emergency-care gatekeeping, Robert A. Lowe, M.P.H., M.D., assistant professor of emergency medicine, and an Oregon colleague found that nearly-one third of patients who were denied telephone pre-authorization for emergency medical care suffered adverse clinical outcomes or were put at an increased risk of death or disability. Lowe advises the insured to make sure they know their managed care company's policies. "If your managed care organization creates barriers so you can't get in to see your doctor when you need to, find a managed care organization that cares about your access to care. And they're out there," he told Channel 10's News Ten. Aired November 19.  

MY CHILD, MY TWIN. . . Should cloning be offered as an option to couples who are unable to have children? "My hunch is this is probably going to be a little frightening, a little too disturbing from the child's point of view," Arthur Caplan, Ph.D., director of Penn's Center for Bioethics, told KYW-TV's News 3. According to Caplan, the heated debate surrounding the issue is telling. "Why are so many people worried about it? I think it tells us some of the fears we have about genetics, about science, about not trusting that people are going to use technologies wisely," he said. Aired November 11.  

STERILIZATION ETHICS. . . Drug-addicted women in California are being offered money to undergo tubal ligations, according to FNC's Fox News Now. The women who participate sign a consent form. But is the procedure really voluntary, given the often desperate circumstances of these women's lives? "Informed consent is more than merely having a piece of paper that you sign. This is a serious medical procedure that we are talking about, an irreversible one," said David Magnus, Ph.D., graduate studies director for the Center for Bioethics and associate professor of cellular and molecular engineering and philosophy. "If you are dealing with someone who's a drug addict being offered a serious financial inducement in a particular context, that may very well be enough so that it does not constitute informed consent," he added. Aired November 14.  

MAPPING OUT CRAVING. . . Many scientists thought cocaine addiction was merely psychological -- not physiological -- because addicts who stop using the drug do not show signs of withdrawal. But studies by Anna Rose Childress, Ph.D., associate clinical professor of psychiatry, show that there is a physiological component of cocaine craving. Childress puts cocaine addicts into PET (positron-emission topography) scanners to pinpoint brain activity, and then shows them films of people using drugs. "Their hearts pitty-pat, they get light-headed, some even experience a minor euphoria," Childress told The Philadelphia Inquirer. And the PET scans reveal that the pleasure centers in addicts' brains light up when watching the drug films. "There's a physical, brain basis to it all," Childress explained. Printed December 1.  

DEATH AND DYING. . . How does a hospital chaplain minister to patients who come from various religious backgrounds, and whose beliefs may or may not align with his? According to the Reverend Ralph Ciampa, director of the pastoral care, it's really not that difficult. "You have to have some way of meeting people at something that is more universal than the particular beliefs of their given faith group," Ciampa told WPVI-TV6's Perspective. "There are particular rituals that are very precious to each religious group. But beyond that, there's a kind of universal humanness that you can reach through at these times very, very effectively." Aired November 1.


MEDIA Review
February, 1998

Linda Bird Randolph, Editor

Roshonda Jones,
Marion Wyce
, Staff

Colleen Hughes-Behler, Designer

Administration:

William N. Kelley, MD, CEO, University of Pennsylvania Medical Center and Health System, and Dean, School of Medicine

Lori Doyle, Chief Public Affairs Officer

Rebecca Harmon, Director of Media Relations


Media Review is published monthly by the University of Pennsylvania Medical Center's Office of Public Affairs to keep the faculty and administration aware of recent Penn-specific media highlights. To make comments, write to Editor, Media Review, 220 Blockley Hall, 3400Spruce Street, Philadelphia, PA 19104


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