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June 23, 2004

The Mother Lode of Mutations
Survey of Zebrafish Early Development Potentially Relevant for Understanding Human Infertility and Birth Defects



Frontal view of wild-type (left) and mutant pollywog embryos one day after fertilization. The eyes in the mutant embryo are widely spaced and embedded in the yolk.

Four days after fertilization wild-type embryos (left) exhibit developed pectoral fins and widely spaced eyes, whereas strongly affected pug mutants lack pectoral fins and display narrow-set eyes.

A bank of zebrafish tanks in the Mullins wet laboratory that are used in breeding experiments

Zebrafish embryo images courtesy of David Wagner; Mary Mullins/Cell Press

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