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November 23, 2004

Molecular Tailoring of Chemotherapy
with Novel Imaging Techniques

Molecular Beacons, Gene Silencing, and Reporter Genes Studied to Better Predict Response to Chemotherapy

Schematic of how a molecular beacon recognizes its target. On the left, a molecular beacon, represented by the sun image, is added to a tumor cell. On the right, after eight hours of being exposed to chemotherapy, the beacon opens up and fluoresces.


Comparing tumor size and KILLER/DR5 silencing using a reporter gene in a mouse model. The human colon tumor on the left (WT) did not have DR silencing compared to the larger colon tumor on the right, shown by more light emission (more red area), which had DR silencing.
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