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| November 23, 2004
Molecular Tailoring of Chemotherapy
with Novel Imaging Techniques
Molecular Beacons, Gene Silencing, and Reporter
Genes Studied to Better Predict Response to Chemotherapy |
 |
| Schematic of how a molecular beacon recognizes its
target. On the left, a molecular beacon, represented
by the sun image, is added to a tumor cell. On the right,
after eight hours of being exposed to chemotherapy,
the beacon opens up and fluoresces. |
|
| Comparing tumor
size and KILLER/DR5 silencing using a reporter gene in
a mouse model. The human colon tumor on the left (WT)
did not have DR silencing compared to the larger colon
tumor on the right, shown by more light emission (more
red area), which had DR silencing. |
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