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January 4, 2005

Study of Hypoxia and New Gene Reveals
Early-Stage Action of p53 Tumor Suppressor Gene

Comparing tumor size after manipulating Bnip3L, which was silenced in the tumor on right.

On the top image, staining tumor sections for apoptosis shows cell death due to wild-type p53 and Bnip3L; whereas, on the bottom, when Bnip3L was silenced a great deal of proliferation is observed.

Peiwen Fei, MD, PhD
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