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PENN Medicine

PENN Medicine is a $3.5 billion enterprise dedicated to the related missions of medical education, biomedical research, and excellence in patient care. PENN Medicine consists of the University of Pennsylvania School of Medicine – founded in 1765 as the nation's first medical school — and the University of Pennsylvania Health System. Penn's School of Medicine is currently ranked
#3 in the nation in U.S.News & World Report's survey of top research-oriented medical schools.
The School has received over $379 million in National Institutes of Health (NIH) research
funds (excluding contract research funds) in the 2006 fiscal year. Supporting over 1,600 fulltime
faculty and 720 students, the School of Medicine is recognized worldwide for its superior education and training of the next generation of physician-scientists and leaders of academic medicine.
The University of Pennsylvania Health System includes three hospitals — its flagship hospital,
the Hospital of the University of Pennsylvania rated one of the nation’s “Honor Roll” hospitals by U.S.News & World Report; Pennsylvania Hospital, the nation's first hospital; and Penn Presbyterian Medical Center — a faculty practice plan; a primary-care provider network; two multispecialty satellite facilities; home care and hospice; as well as a nursing home. Multidisciplinary units reaching across the School of Medicine and the Health System foster research initiatives to advance patient care. Some of PENN Medicine’s centers and institutes include:

■ Abramson Cancer Center of the University of Pennsylvania
■ Penn Cardiovascular Institute
■ Institute for Diabetes, Obesity, and Metabolism
■ Institute for Translational Medicine and Therapeutics
■ Center for Clinical Epidemiology and Biostatistics
■ Center for Bioethics
■ Institute on Aging
■ Institute for Medicine and Engineering
■ Center for Research on Reproduction and Women's Health
■ Center for AIDS Research
■ Center for Research on Early Detection and
Cure of Ovarian Cancer

Fiscal Year 2007 Profile

A Sample of Biomedical Achievements in the Past Century
■ Development of parenteral nutrition (TPN), or the practice of feeding a person intravenously
■ Pioneering of computed tomography (CT) and positron emission tomography (PET) imaging
■ Discovery of the Philadelphia Chromosome, the first defective chromosome linked to cancer
■ Development of cognitive therapy
■ Development of Retin-A for acne and wrinkles
■ Pioneering of human in-vitro fertilization and endoscopic surgery
■ Discovery of expanded, tiplet nucleotides repeats as a cause of mutations leading to human disease
■ Pioneered the study of islet cell transplantation as a method of treating insulin-dependant diabetes
■ Discovery of the genes for Fragile X Syndrome, Kennedy's disease, and Charcot-Marie-Tooth disease
■ Pioneering basic clinical applications of gene transfer
■ Development of cure for atrial fibrillation
■ Discovery of hormone that triggers type 2 diabetes
■ Discovery of several genes implicated in congenital heart disease
■ Development of new therapy for sickle cell disease
■ Discovery of genes contributing to Prader-Willi/Angelman syndrome
■ Discovery of the genetic mutation that may have led to human evolution
■ Discovery of the genetic mutation that causes Fibrodysplasia Ossificans Progressiva (FOP)

University of Pennsylvania School of Medicine
www.med.upenn.edu

Facts and Figures
■ Founded in 1765 as the nation’s first medical school
■ Featured in U.S.News & World Report's “Best Graduate Schools,” ranking 3rd out of 125 medical schools in the nation
■ 720 medical students
■ 1,006 residents and fellows
■ 611 postdoctoral fellows working in 58 departments, divisions, and centers in the School of Medicine
■ 2007 Entering Class: 153 admitted; 52% male, 48% female, 15% under-represented minorities
■ Approximately 86% of all students receive financial aid
■ Awarded 34 patents for FY07
■ 2,581 School of Medicine employees
■ 2.15 million net square feet; 10 interconnected buildings on the School of Medicine’s core campus plus 20 sites in and around West Philadelphia
■ Approximately 1.2 million net square feet research space; a new research building of 300,000 net square feet scheduled to open in 2010

The curriculum of the University of Pennsylvania School of Medicine centers on the Science of Medicine, the Art and Practice of Medicine, and Professionalism and Humanism.
Special programs include the “Doctoring” course, a four-year, patient-centered experience in which pairs of medical students follow a chronically ill patient to better understand the consequences on the patient and family.

Biomedical Graduate Studies
• PhD training degree programs in biochemistry and molecular biophysics, cell and molecular biology, epidemiology and biostatistics, genomics and computational biology, immunology, neuroscience, pharmacological sciences, as well as bioengineering and biology as affiliate programs.
• 548 full-time pre-doctoral students who are generally awarded financial support for the five years required, on average, to obtain the PhD degree.
• 131 biomedical graduate students enrolled in combined degree programs.
• Penn's NIH-sponsored Medical Scientist Training Program is one of the largest in the nation.

Masters Degree Programs
• Bioethics
• Clinical Epidemiology
• Biostatistics

Research
• 46.2% of all NIH dollars coming into all Pennsylvania medical schools are the result of research done at Penn’s School of Medicine.
• In Federal FY 2006, Penn's School of Medicine received $379 million (excluding contracts) in total National Institutes of Health (NIH) support.
This includes:
-$355 million in NIH research awards.
-$21 million in NIH training grants.
• Major research facility of the Howard Hughes Medical Institute (HHMI),
with a total of five investigators from the School of Medicine.

University of Pennsylvania Health System
www.pennhealth.com

The University of Pennsylvania Health System (UPHS) was created in 1993 and includes three hospitals — its flagship hospital, the Hospital of the University of Pennsylvania, rated one of the nation’s “Honor Roll” hospitals by U.S.News & World Report; Pennsylvania Hospital, the nation's first hospital; and Penn Presbyterian Medical Center — a faculty practice plan; a primary-care provider network; two multispecialty satellite facilities; home care, hospice and nursing home.
Physicians who practice at the Health System are featured in the 2007 Philadelphia Magazine's "Top Docs" issue.

The Health System’s role as a major “safety net” provider for uninsured and under-insured patients is rooted in its long and uninterrupted tradition of community service, as well as its modern-day mission and values. When the Hospital of the University of Pennsylvania was established over 130 years ago as the nation’s first teaching hospital, it began its fruitful association with its West Philadelphia neighbors. Today, that rich tradition of community service remains unchanged and
is expressed by all UPHS hospitals, as Penn caregivers provide an enormous level of charity care.

The level of the Health System’s financial commitment to uncompensated care is significant. In FY07, charity and underfunded care for Medicaid families totaled $102 million. The Raymond and Ruth Perelman Center for Advanced Medicine, opening in 2008, will be a state-of-the-art, 360,000+ square foot outpatient facility located adjacent to the Hospital of the University of Pennsylvania.

The $232 million facility is the largest capital project undertaken in the history of the University of Pennsylvania Health System. It is designed to create an ideal environment for patient-focused care and collaboration among health professionals. The Perelman Center will house the Health System's Abramson Cancer Center, radiation oncology, cardiovascular medicine and an outpatient
surgical pavilion. The Roberts Proton Therapy Center, opening in 2009, will be a first-of-its-kind
proton therapy center for the treatment of cancer.

In addition to providing access to world-class medical care for Philadelphia's residents, The Perelman Center also improves the economic health of the city by creating new jobs. Recognizing this positive impact, federal, state and local governments are providing more than $20 million in support of the project, and individual donors have already contributed $56 million.

Hospital of the University of Pennsylvania
3400 Spruce Street, Philadelphia PA 19104
(215) 662-4000 | www.pennhealth.com/hup

Founded in 1874 as the nation's first teaching hospital, the Hospital of the University of Pennsylvania (HUP) is the flagship hospital of the University of Pennsylvania Health System.

The hospital provides a comprehensive range of both in- and outpatient services, including highly specialized tertiary and quaternary levels of care in more than 200 specialty programs and clinics.

HUP has also been recognized as an “Honor Roll” hospital by U.S.News & World Report and achieved Magnet status – the highest institutional honor awarded for nursing excellence – from the American Nurses Credentialing Center (ANCC).

Specialties include: Cancer and Cancer Genetics; Cardiovascular Services (electrophysiology, Heart Failure & Transplant Program, Robotic Surgery Programs, Philadelphia Adult Congenital Heart Program); Neurology (Stroke Center, Alzheimer's Disease Center, Parkinson's Center, Epilepsy Clinic); Women's Health (including infertility and high risk pregnancy); Diabetes; Multi-Organ Transplant Program; Neurosurgery (brain disorders including tumors and aneurysms, spinal disorders including disc, cervical , thoracic and lumbar abnormalities, stenosis and peripheral nerve damage); Institute on Aging; Vascular Laboratory, Orthopaedic Surgery; Gastroenterology, and Ophthalmology.

Following the award of a NIH Roadmap Clinical and Translational Science Award (CTSA) in 2006, the General Clinical Research Centers (GCRC) of Penn and the Children's Hospital of Philadelphia were integrated to form the Clinical and Translational Research Center (CTRC) within Penn’s Institute for Translational Medicine and Therapeutics (ITMAT). The CTRC conducts mechanistic studies of human physiology and disease, studies of drug action, and serves as a center for clinical trials conducted in a controlled environment. Particular emphasis is
placed on the development of strategies to evoke phenotypes in humans which elucidate the role of genetic variation in conditioning drug response and on studies which cross the artificial divide
between pediatric and adult medicine. Major areas of investigation include AIDS, the cardiovascular system, chronobiology, dermatology, endocrinology, regenerative medicine, metabolism, neurology, oncology, psychiatry, and women's and minority health issues.

HUP's Level I Trauma Center includes PennSTAR, our critical-care flight
program, which operates six helicopters servicing Eastern Pennsylvania,
New Jersey, Delaware, and beyond. Since its inception in 1988, PennSTAR
has safely flown more than 20,000 patients.

The Abramson Cancer Center (ACC) of the University of Pennsylvania, established in 1973, is a national leader in cancer research, patient care, and education. It has been designated as a Comprehensive Cancer Center by the National Cancer Institute for 30 years, one of 39 such Centers in the United States. The ACC is dedicated to innovative and compassionate cancer care.

The clinical program — comprised of a dedicated staff of physicians, nurse practitioners, nurses, social workers, physical therapists, nutritionists and patient support specialists, currently sees over 50,000 outpatient visits, 3,400 inpatient admissions, and provides over 25,000 chemotherapy treatments and more than 65,000 radiation treatments annually. In addition, the ACC is home to 300 research scientists who work relentlessly to determine the pathogenesis of cancer. Together, the faculty is committed to improving the prevention, diagnosis, and treatment of cancer. More information is available at penncancer.org.

Penn Presbyterian Medical Center
3900 Market Street, Philadelphia PA 19104
(215) 662-8000 | www.pennhealth.com/presby

Facts and Figures

Named one of the nation's Top 100 Cardiovascular Hospitals by Solucient.

■ 317 licensed beds
■ 26 long-term care beds
■ 124 nursing home beds
■ 2,047 employee.
■ 832 physicians
■ 15,419 adult admissions
■ 116,757 outpatient visits
■ 33,038 Emergency Department visits
■ 10 interconnected buildings; 617,900 net square feet

Penn Presbyterian was founded in 1871 as a 45-bed facility on 2 1/2 acres. Today the medical center spreads across a 16-acre campus and includes a large array of medical institutes, specialty
centers and research programs. Penn Presbyterian offers its patients state-of-the art services, from primary and family care to the most complex medical and surgical treatments available.

Specialties include: Penn Cardiac Care, including Cardiovascular Medicine and Cardiothoracic Surgery; Robotic Prostatectomy; Minimally Invasive Surgery; Penn Orthopaedics; Scheie Eye
Institute – Ophthalmology; Pulmonary Medicine with Specialty Programs in Pulmonary Hypertension, Cystic Fibrosis and Smoking Cessation; Thoracic Surgery; Specialized Medical Care
for the Ederly.

Pennsylvania Hospital
800 Spruce Street, Philadelphia PA 19107
(215) 829-3000 | www.pennhealth.com/pahosp

Facts and Figures

Pennsylvania Hospital – the nation’s first – was founded in 1751 by Benjamin Franklin and Dr. Thomas Bond. Today, the acute care facility offers a full-range of diagnostic and therapeutic medical services and is a major teaching and clinical research institution. The campus, located in the historic Society Hill district, also includes specialty treatment centers such as the Joan Karnell Cancer Center, the Center for Bloodless Medicine and Surgery, the PENN Neurological Institute, and the radiosurgical Gamma Knife® Center.

Specialties include: Orthopaedics; Cardiac Care; Vascular Surgery; Neurosurgery; Otorhinolaryngology (ENT); Urology; Obstetrics, including high-risk maternal and fetal services; Neonatology; and Behavioral Health.

Satellite and Off-Site Clinical Services

Clinical Care Associates (CCA) is a primary and specialty care network with 38 practice locations throughout the five-county Philadelphia metropolitan service area.

Clinical Health Care Associates of New Jersey, PC (CHCA) is a primary and specialty care network with practices located at 13 Philadelphia and southern New Jersey locations.

Penn Medicine at Bucks County offers Internal and Family Medicine; radiology services as well as pathology and laboratory services.

Penn Medicine at Cherry Hill offers patients specialty and primary care at a convenient Cherry Hill location. Specialties include: Family Medicine; Orthopaedics; and Hematology/Oncology.

Penn Cardiology at Cherry Hill provides outpatient cardiac care including echocardiography and nuclear stress testing.

Penn Medicine at Radnor offers patients premier specialty and primary care with expertise in more than 30 specialties, as well as an on-site laboratory, pharmacy and optical shop, and radiology services including a women’s imaging center and MRI.

Penn Center for Rehabilitation and Care is a 124-bed skilled and rehabilitative nursing facility located in Philadelphia. Penn Home Care & Hospice Services provides comprehensive care to
approximately 17,000 patients in and around the Philadelphia area annually. Penn Home Care & Hospice Services is comprised of three fully integrated divisions:

Penn Care at Home, a Medicare-certified home health agency, provides approximately 115,000 visits by nurses, home health aides, social workers, and physical, occupational, and speech therapists per year.

Penn Home Infusion Therapy provides home infusion therapy, pharmaceuticals, and skilled nursing care to patients in the Philadelphia region and in parts of New Jersey and Delaware.

Wissahickon Hospice, a certified hospice and home-health agency, provides hospice and palliative care to terminally ill adult patients and their families.

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The University of Pennsylvania Health System, Philadelphia, PA 1-800-789-PENN © 2008, The Trustees of the University of Pennsylvania