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Reproductive Endocrinology and Infertility

Reproductive Endocrinology and Infertility

Matthew VerMilyea, PhD
Director , Assisted Reproductive Technologies and Andrology Laboratories

University of Pennsylvania Health System
Department OB/GYN

Suite 800
3701 Market Street
Philadelphia, Pa 19104

Assisted Reproductive Technology Laboratory

The overall goal of the ART laboratory is to support the in-vitro fertilization (IVF) program and provide patients seeking assisted reproductive treatment with safe, effective, and successful outcomes.

The Assisted Reproductive Technology (ART) Laboratory at the University of Pennsylvania features state-of-the-art equipment and cutting edge technology that positions Penn Fertility Care at the forefront of individualized patient care.  In 2013, under the directorship of Dr. Matthew (Tex) VerMilyea, a board-certified High Complexity Clinical Laboratory Director (HCLD), the ART laboratory at Penn Medicine underwent a modernization and technological renovation that provides patients with the best possible care available.  By utilizing controlled microenvironment incubation, non-invasive embryo culture protocols and continuous time-lapse embryo surveillance technology, the ART laboratory provides effective fertility treatment for patients pursuing family building options.  With the implementation of such novel devices and modern methods in our laboratory, Dr. VerMilyea is often asked to speak at seminars and conferences worldwide, with the intent to educate others to achieve greater success. This reputation and experience in the field of ART has a direct impact on patient care thereby providing the best possible chance at success.

Current Research and Scholarly Interests:

  • Continuous uninterrupted embryo culture protocols
  • Clinical application of extended culture (Blastocyst culture)
  • Vitrification of supernumerary embryos
  • Natural frozen embryo transfer cycles
  • Oocyte freezing and preservation
  • Ovarian and testicular tissue preservation and maintenance
  • Non-invasive embryo culture           
    • Time-lapse video imagery
    • Controlled micro-environment
    • Reduced oxygen culture
  • Epigenetics and embryo selection
  • Sperm motility and maturation markers
  • Improving IVF outcomes with single embryos in older patients
  • Preimplantation Genetic Diagnosis (Embryo Screening)
  • Intracytoplasmic Sperm Injection (ICSI)
  • Automated vitrification and embryo handling

Active Clinical Trials

For a complete listing of all active clinical trials, please visit:

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