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Maternal Fetal Medicine

Maternal Fetal Medicine

Samuel Parry, MD
Chief, Division of Maternal-Fetal Medicine

University of Pennsylvania Health System
Department of OB/GYN

Division of Maternal Fetal Medicine
3400 Spruce Street
2nd Floor Silverstein Bldg.
Philadelphia, PA 19104

Clinical Office:
Phone: (215)662-2982

Academic Office
Phone: (215)662-6913
Fax: (215)349-5625

The Division of Maternal-Fetal Medicine is an integral component of the Department of Obstetrics and Gynecology. We are committed to providing the highest level of obstetric care, prenatal consultations and ultrasound services, medical education, and clinical and translational research.

The MFM division provides diagnostic and consultative services focused on high-risk obstetrics at the Hospital of the University of Pennsylvania. Division members are experienced prenatal sonographers who provide a full range of ultrasound services, including antepartum testing, Down syndrome screening, 3D ultrasound, and ultrasound-guided procedures. The division maintains a relatively small practice that provides prenatal care for women with difficult pregnancy complication, including maternal cardiac disease, organ transplants, cancer, and congenital malformations. Additionally, faculty members provide consultative and diagnostic ultrasound services at a number of affiliated practices and hospitals in the greater Philadelphia region. Division members have experience and expertise in managing pregnancies complicated by the full range of medical and obstetric disorders, including:

  • hypertensive disease
  • diabetes mellitus
  • multiple gestation including triplets, quadruplets, and multifetal pregnancy reduction
  • Rh disease
  • platelet and blood disorders such as thrombocytopenia, sickle cell anemia and the thalassemias
  • collagen vascular diseases such as lupus
  • maternal cardiac, neurologic, gastrointestinal, and renal disease
  • antiphospholipid antibody syndrome
  • recurrent pregnancy loss including cervical insufficiency

The division also is skilled in the management of pregnancies complicated by fetal abnormalities, including growth disorders, inherited diseases, and structural malformations. Division members are affiliated with the Center for Fetal Diagnosis and Treatment at the Children's Hospital of Philadelphia and provide the prenatal diagnosis and obstetric management for patients who need either fetal treatment or neonatal surgical management.

Scheduled prenatal diagnostic consultation and targeted ultrasound examinations are available through the MFM division five days a week. Invasive diagnostic and therapeutic procedures such as amniocentesis, chorionic villus sampling, and umbilical cord blood sampling are performed in the division's ultrasound suite at the Hospital of the University of Pennsylvania, as well as some suburban locations. A faculty perinatologist is on call at all times for emergency consultations and maternal transport.

Division faculty are fully involved in the supervision and staffing of the Labor and Delivery unit, and a division member is either present on the labor floor or available 24 hours a day for assistance with the intrapartum management of high-risk pregnancies.

Clinical and research interests of the MFM division encompass the entire field of obstetrics and maternal-fetal medicine. Some of the current and recent projects involve:

  • a study of the impact of viral infection on placental function and pregnancy outcomes
  • risk factors, including placental viral infection, associated with second trimester pregnancy loss
  • genomics and proteomics research and preterm birth
  • a study of protein markers in cervical secretions that predict preterm delivery
  • a randomized control trial of therapeutic interventions for periodontal disease in pregnancy and the risk of preterm birth
  • a study of new drugs, including progesterone, to prevent preterm birth
  • an investigation of adverse neonatal neurological outcomes associated with inflammation-induced preterm delivery
  • a study of novel serum biomarkers that predict preeclampsia
  • a study of Doppler ultrasound indices that predict preeclampsia
  • a study of polymorphisms in genes that regulate cardiovascular physiology in association with preeclampsia risk
  • an investigation of transport proteins in the placenta that affect drug delivery to the fetus
  • a study of 3D sonographic measurements that predict birth weight in complicated pregnancies
  • a decision analysis that evaluates diagnostic and therapeutic options in the management of Rh disease
  • a study of maternal thyroid disease and fetal growth
  • a study of congenital diaphragmatic hernias, amniotic fluid volume, and pregnancy outcomesa study of the impact of viral infection on placental function and pregnancy outcomes

Active Clinical Trials

For a complete listing of all active clinical trials, please visit:


Hospital of the University of Pennsylvania

Pennsylvania Hospital

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