McKay Orthopaedic Research Laboratory
The McKay Orthopaedic Research Laboratory embodies the principles that guide orthopaedic research at the University of Pennsylvania: interdisciplinary effort, common-use facilities, scientific collaboration, and collegial discussion. The McKay Lab occupies more than 15,000 square feet of space in the School of Medicine, and is populated by more than 70 research personnel and six principal investigators.
Research expenditures in McKay total more than $5 million per annum, supported largely through extramural funding including grants from the National Institutes of Health (NIH), private foundations, and industry. Penn Orthopaedics is ranked in the top five of Orthopaedic Departments nationally in terms of NIH funding. Moreover, the McKay Lab serves as the focal point for the Penn Center for Musculoskeletal Disorders, a university-wide Center that provides resources and a forum for scientific exchange through annual symposia, a year-long seminar series, a pilot grant program and other activities.
Penn Orthopaedics research foci include:
- Connective tissue extracellular matrix biophysics and cell biology
- Tendon and ligament injury and repair
- Fibrodysplasia Ossificans Progressiva and other disorders of heterotopic ossification
- Genetic and cellular regulation of osteogenesis and chondrogenesis
- Intervertebral disc and soft tissue mechanics
- Musculoskeletal tissue engineering
- Bone metabolism and cancer-associated bone diseases
- Stem cell mechanobiology
- Mesenchymal stem cell maintenance and differentiation
- Musculoskeletal aging and disease
For more information, please visit the McKay Orthopaedic Research Laboratory website.
International FOP Association (IFOPA)
A nonprofit support organization for families dealing with a rare genetic condition known as Fibrodysplasia Ossificans Progressiva (FOP). Frederick S. Kaplan, MD, and Eileen M. Shore, PhD, of Penn Medicine's Department of Orthopaedic Surgery are the directors of the only lab in the country dedicated to (FOP) research.