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Kaplan
Pyeritz
Wilson

Division of Medical Genetics

Reed E. Pyeritz, MD, PhD, Chief

Academic Title
Professor of Medicine and Genetics

Hospital/Administrative Title
Chief, Division of Medical Genetics

Address
Division of Medical Genetics, Maloney 538
University of Pennsylvania School of Medicine
3400 Spruce Street
Philadelphia, PA 19104-4283
Tel: 215-662-4740
Fax: 215-614-0298

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Board Certified
Diplomate American Board of Internal Medicine
Diplomate American Board of Medical Genetics (Clinical Genetics)

Residency
Resident in Medicine, Peter Bent Brigham Hospital, Boston MA
Resident in Medicine, Johns Hopkins Hospital, Baltimore

Research Interests

Dr. Pyeritz focuses his research in Mendelian disorders of the cardiovascular system, especially those involving defects of connective tissue. He is continuing his studies, begun over 20 years ago, of Marfan syndrome, a disease in which the aorta gradually enlarges and dissects, leading to early demise if untreated. Current efforts are directed at understanding the pathogenesis of aneurysm formation and dissection; the plan is to determine the risk factors predicting dissection and to use magnetic resonance imaging to measure indices of aortic wall tension. One goal is to develop better and individualized criteria for recommending prophylactic aortic root replacement.

(See also under Faculty Research Interests.)

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