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Hometown
New York City , New York
College
Amherst College, Amherst, MA
Medical School
Cornell University Medical College , New York , NY
Graduate School
The Rockefeller University
Internship and Residency in Internal Medicine
Hospital of the University of Pennsylvania
Fellowship: Location
Hospital of the University of Pennsylvania
Sub-specialty Fellowship: Area of Concentration
Hematology/Oncology
Year Appointed to Penn Faculty
2004
Areas of Expertise
Cancer Genetics and Genomics
Familial Cancer syndromes and Cancer Risk Evaluation
Cancer Biology
Molecular Biology
Clinical Trials
Areas of Special Interest
Genomic Characterization of Cancers of the Head and Neck, Thyroid and Lung
Novel Drug Target Discovery
Use of Genetic Testing in Diagnosis, Prognostication and Treatment of Cancer
Current Research Interests
Tobacco Related Cancers:
Head and Neck Squamous Cell Cancer, Lung Cancer, Esophageal Cancer.
Thyroid Cancer
Positions Held in Major Societies (Past & Present)
Associate Member, American Academy of Otolaryngology-Head and Neck Surgery 2005
Member, American Thyroid Association 2005
Member, American Society of Human Genetics 2005
American Society of Clinical Oncology
Member, Fellows Task Force 1999-2001
Public Issues Committee 2002-2004
American Association of Cancer Research
American Head and Neck Society
Research Grants
NIH Medical Scientist Training Program Fellowship, 1987 - 1995.
Carol and Otto Haas Jr. Faculty Fellow, Division of Hematology and Oncology,
Hospital of the University of Pennsylvania , 2001-2002
NIH KO8 – Physician Scientist Training Grant 2003-2008.
NIH RO1 CA076417-08 "Human and Marine models of BRCA1 tumorigenesis"
ACS Institutional Pilot Program grant: 2003-2004.
Commonwealth of Pennsylvania Funding: Tobacco related research: 2003-2006
The V-Foundation for Cancer Research, V-Scholar Award 2004-2006
Damon Runyon-Siemens Clinical Investigator Award 2005-2010 Honors & Awards
Alavi Award for Cancer Research Excellence 2005
General Motors Cancer Research Foundation, Research Scholar Award – 2002-2003
AFCRI Research Award, Abramson Family Cancer Research Institute Symposium, 2002
ASCO Young Investigator Award 2000-2001 Homozygous BRCA1 knockout in Human Cell Lines.
Lehigh Valley Fellows Research Symposium on Research in Palliative Care , Research Award 1998
Young Investigator Award, Gene Regulation and Cancer, Travel award AACR Special Conference, 1998 William Osler Society, Fellows in Medicine, Hospital of the University of Pennsylvania, 1997
Oscar E. Shotte Award, Best thesis in Biology, Amherst College, May 1986.
Phi Beta Kappa, Membership, Beta of Massachusetts, Amherst College, May 1986.
Recent Publications:
Brose, M.S., Smyrk, T., and Lynch, H.T. Genetic Predisposition to Cancer, Cancer Medicine 7 th Edition, B.C. Decker, (in press).
Brose, M.S ., Volpe, P., Stopfer, J.E., Calzone, K.A., and Weber, B.L. Characterization of two novel BRCA1 germline mutations involving the splice donor sites of exon 3 and exon 17. Genetic Testing 8(2) 133-138 (2004). Flaherty KT, Brose M. S., New molecular targets in melanoma. Curr Opin Oncol. Mar;16(2):150-154 (2004).
Keith T. F., Tuveson, D.A., Schuchter, L. M., Redlinger, M., Lee, R., Lathia, C., Schwartz, B., Brose, M.S., Weber, B.L., Schiller L., O’Dwyer, P.J., A Phase I Trial of a Novel Kinase Inhibitor BAY 43-9006 in Combination with Carboplatin and Paclitaxel (manuscript submitted)
Huang, J., Domcheck S. M., Brose, M.S., Rebbeck, T. R., Nathanson, K. L., and Weber, B. L. Germline CHEK21100delC mutations in breast cancer patients with multiple primary cancers. J.Med.Genet (2004) 41:e120.
Edwards, R. H., Ward, M. R., Wu, H., Medina, C. A., Brose, M. S., Volpe, P., Nussen-Lee, S., Haupt, H. M., Martin, A.-M., Herlyn, M., Lessin, S. R., Weber, B. L.. Absence of BRAF Mutations in UV-protected Mucosal Melanomas. Journal of Medical Genetics (2004) 41:270-272.
Sataymoorthy, K., Li, G., Gerrero, R. Brose, M.S., Volpe, P., Weber, B.L., van Belle, P., Elder, D.E., and Herlyn, M. Constitutive MAP kinase activation in melanoma is mediated by both BRAF Mutations and Autocrine Growth Factor Stimulation . Cancer Research, 63:756-759 (2003).
Brose, M.S., Smyrk, T., Weber, B.L., and Lynch, H.T. Genetic Predisposition to Cancer, Cancer Medicine 6 th Edition, B.C. Decker, (2003).
American Society of Clinical Oncology: Update of the Statement of the American Society of Clinical Oncology: Genetic Testing for Cancer Susceptibility. J. of Clinical Oncology 21(12):1-10 (2003).
American Society of Clinical Oncology. Policy Statement: Tobacco Control: Reducing Cancer Incidence and Saving Lives J. of Clinical Oncology 21(14):1-10 (2003).
Brose, M. S. , Comment in: Cancer Genomics: Revolutionizing treatment and reshaping markets through targeted therapies. Report #31, CHI Insights, L.L.C., Newton, MA , August (2003), p98.
Brose, M.S., Rebbeck, T.R., Stopfer, J., Calzone, K.L., Nathanson, K.L., and Weber, B.L. Cancer penetrance estimates for BRCA1 carriers identified in a cancer risk evaluation program. J. of the National Cancer Institute 94 (18):1365-1372 (2002).
Brose, M.S., P. Volpe, M. Feldmnan, M. Kumar, I. Rishi, (14 additional authors), and B.L. Weber. BRAF and RAS mutations in human lung cancer and melanoma. Cancer Research 62:6997-7000 (2002).
K.L. Nathanson, T.C. Smyrk, M.S. Brose, H.T. Lynch, B.L. Weber. Cancer Genetics, Oxford Textbook of Surgery, 2 nd edition, Oxford University Press, 2000.
Sparano, A., Quesnelle, K.M., Kumar, M.S., Wang, Y., Sylvester, A.J., Feldman, M., Sewell D.S., Weinstein, G.S., and Brose, M.S . Fanconi Anemia Pathway and Cancer-Related Genes Implicated in OSCC by aCGH. Laryngoscope . (Submitted). |
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